Salivary Cortisol Increases After Bariatric Surgery in Women

Valentine, A.R.; Raff, Hershel; Liu, H.; Ballesteros, M. M. Ruiz; Rose, Jennifer M.; Jossart, Gregg H.; Cirangle, Paul T.; Bravata, Dena M

doi:10.1055/s-0031-1279777

Cited by 13 publications

(11 citation statements)

References 7 publications

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“…Data from 3 prior weight loss studies, using surgical and non-surgical methods, resulted in changes to the diurnal cortisol profile shifting it toward more normal dynamics (e.g. higher awakening and 30 minute cortisol) and decreased overall HPA axis drive [41–43]. Given that the blunted cortisol diurnal profile has been associated with other metabolic (e.g.…”

Section: Discussionmentioning

confidence: 99%

Antecedent longitudinal changes in body mass index are associated with diurnal cortisol curve features: The multi-ethnic study of atherosclerosis

et al. 2017

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Context-Prior studies have shown a cross-sectional association between body mass index (BMI) and salivary diurnal cortisol profile features (cortisol features); however, to our knowledge prior population-based studies have not examined the longitudinal association of body-mass index (BMI) with cortisol features.Objective-To examine the association of (1) prior annual BMI percent change over 7 years with cortisol features, (2) baseline cortisol features with subsequent change in BMI over 6 years and (3) the association of change in cortisol features with change in BMI over 6 years.Corresponding author and person to whom reprint requests should be addressed: Joshua J. Joseph, MD, Department of Medicine, The Ohio State University Wexler Medical Center, 566 McCampbell Hall, 1581 Dodd Drive, Columbus, OH 43210, Phone: 614-346-8878, Fax: 614-366-0345, joseph.117@osu.edu. Disclosure Statement The authors have no relevant conflicts of interest to disclose. Author ContributionsAll authors contributed to the design and conduct of the study, data collection and analysis, data interpretation, manuscript writing and gave final approval of the version to be published.Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. (2004-2006 & 2010-2012) Participants-1,685 ethnically diverse men and women attended either MESA Stress exam (mean age 65 ± 10 years at MESA Stress I; mean age 69 ± 9 years at MESA Stress II). HHS Public AccessOutcome Measures-Log-transformed cortisol features including wake-up cortisol, cortisol awakening response, early decline slope (30 minutes to 2 hours post-awakening), late decline slope (2 hours post-awakening to bedtime), bedtime, and total area under the curve (AUC) cortisol.Results-Over 7 years, following multivariable adjustment, (1) a 1% higher prior annual BMI % increase was associated with a 2.9% (95% CI: −5.0%, −0.8%) and 3.0% (95% CI: −4.7%, −1.4%) lower current wake-up and total AUC cortisol, respectively; (2) there was no significant association between baseline cortisol features and subsequent change in BMI and (3) among participants with BMI ≥ 30 kg/m 2 , flattening of the late decline slope was associated with increases in BMI (every 1-unit increase late decline slope were associated with a 12.9% increase (95%CI: −1%, 26.8%) in BMI, respectively).Conclusions-We found a significant association between prior annual BMI % change and cortisol features, but no significant association between baseline cortisol features and subsequent change in BMI. In participants with obesity increases in BMI were associated with less pronounced declined. Collect...

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Section: Discussionmentioning

confidence: 99%

Antecedent longitudinal changes in body mass index are associated with diurnal cortisol curve features: The multi-ethnic study of atherosclerosis

et al. 2017

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“…An increase in HPA axis tone during weight loss through food restriction can weaken behavioral modifications, which would make patient compliance to the prescribed diet and sustained weight loss in the long term difficult (177–179). Current evidence suggest that BS can affect HPA axis regulation, but controversial results have been found regarding the direction of this regulation (116, 119–121). Cortisol increases immediately after BS due to the acute stress caused by the surgery itself (180).…”

Section: Non-metabolic Bs-induced Endocrine Alterationsmentioning

confidence: 99%

Metabolic and Endocrine Consequences of Bariatric Surgery

2019

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Obesity is one of the most serious worldwide epidemics of the twenty-first century according to the World Health Organization. Frequently associated with a number of comorbidities, obesity threatens and compromises individual health and quality of life. Bariatric surgery (BS) has been demonstrated to be an effective treatment to achieve not only sustained weight loss but also significant metabolic improvement that goes beyond mere weight loss. The beneficial effects of BS on metabolic traits are so widely recognized that some authors have proposed BS as metabolic surgery that could be prescribed even for moderate obesity. However, most of the BS procedures imply malabsorption and/or gastric acid reduction which lead to nutrient deficiency and, consequently, further complications could be developed in the long term. In fact, BS not only affects metabolic homeostasis but also has pronounced effects on endocrine systems other than those exclusively involved in metabolic function. The somatotropic, corticotropic, and gonadal axes as well as bone health have also been shown to be affected by the various BS procedures. Accordingly, further consequences and complications of BS in the long term in systems other than metabolic system need to be addressed in large cohorts, taking into account each bariatric procedure before making generalized recommendations for BS. In this review, current data regarding these issues are summarized, paying special attention to the somatotropic, corticotropic, gonadal axes, and bone post-operative health.

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“…The latter possibility merits further investigation because one of the aggregate diurnal cortisol measures—morning cortisol—did show a small, nonsignificant rise following surgery. Valentine and colleagues (2011) also found a rise in morning cortisol after surgery, which was significant for their sample (n = 24). A higher morning cortisol could be interpreted as an improvement in physiological health following bariatric surgery, as evidenced by a steepening of the downward curve of diurnal cortisol secretion.…”

Section: Discussionmentioning

confidence: 83%

“…The objective of the second aim was to determine if bariatric surgery itself affects diurnal patterns of cortisol secretion. Only a few studies have examined HPA axis regulation before and after bariatric surgery, and the results suggest that bariatric surgery may affect HPA axis regulation (Guldstrand et al, 2003; Manco et al, 2007; Valentine et al, 2011). …”

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confidence: 99%

Pilot Study on Childhood Sexual Abuse, Diurnal Cortisol Secretion, and Weight Loss in Bariatric Surgery Patients

Hulme

McBride

Kupzyk

et al. 2015

Journal of Child Sexual Abuse

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Childhood sexual abuse increases risk for adult obesity. A potential contributing factor is altered cortisol secretion. In this pilot study, relationships among childhood sexual abuse, diurnal salivary cortisol secretion, and weight loss were explored in 17 bariatric surgery patients. Measurement points were before surgery (baseline) and 3 and 6 months after surgery. Childhood sexual abuse was measured by the Childhood Trauma Questionnaire. The results showed moderate but nonsignificant positive correlations between the childhood sexual abuse subscale score and baseline morning cortisol, evening cortisol, and daily mean cortisol. An unexpected positive correlation was noted between the Childhood Trauma Questionnaire total score and weight loss at six months. Diurnal cortisol secretion did not change over time after surgery nor correlate significantly with weight loss at six months.

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Salivary Cortisol Increases After Bariatric Surgery in Women

Cited by 13 publications

References 7 publications

Antecedent longitudinal changes in body mass index are associated with diurnal cortisol curve features: The multi-ethnic study of atherosclerosis

Antecedent longitudinal changes in body mass index are associated with diurnal cortisol curve features: The multi-ethnic study of atherosclerosis

Metabolic and Endocrine Consequences of Bariatric Surgery

Pilot Study on Childhood Sexual Abuse, Diurnal Cortisol Secretion, and Weight Loss in Bariatric Surgery Patients

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