Salivary Secretion of Chromogranin A Control by Autonomic Nervous System

Kanno, Tomio; Asada, Naoto; Yanase, Haruko; Iwanaga, Toshihiko; Yanaihara, Noboru

doi:10.1007/0-306-46837-9_11

Cited by 21 publications

(17 citation statements)

References 21 publications

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“…A current clinical trial is examining the expression of chromogranin A in periodontitis. The endocrine protein chromogranin A has been detected in saliva (Kanno et al 2000) and is the precursor for potential antimicrobial peptides (Shooshtarizadeh et al 2009). The goal is to determine if chromogranin peptides exhibit antimicrobial activity in gingival crevicular fluid samples from diabetic patients with and without periodontitis (ClinicalTrials.gov Identifier: NCT00399620).…”

Section: Regulation Of Antimicrobial Peptide Expressionmentioning

confidence: 99%

Antimicrobial peptides and periodontal disease

Gorr

Abdolhosseini

2011

J Clinic Periodontology

152

158

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Aims: The goal of this review is to identify the antimicrobial proteins in the oral fluids, saliva and gingival crevicular fluid and identify functional families and candidates for antibacterial treatment. Results: Periodontal biofilms initiate a cascade of inflammatory and immune processes that lead to the destruction of gingival tissues and ultimately alveolar bone loss and tooth loss. Treatment of periodontal disease with conventional antibiotics does not appear to be effective in the absence of mechanical debridement. An alternative treatment may be found in antimicrobial peptides and proteins, which can be bactericidal and anti-inflammatory and block the inflammatory effects of bacterial toxins. The peptides have co-evolved with oral bacteria, which have not developed significant peptide resistance. Over 45 antibacterial proteins are found in human saliva and gingival crevicular fluid. The proteins and peptides belong to several different functional families and offer broad protection from invading microbes. Several antimicrobial peptides and proteins (AMPs) serve as templates for the development of therapeutic peptides and peptide mimetics, although to date none have demonstrated efficacy in human trials. Conclusions: Existing and newly identified AMPs may be developed for therapeutic use in periodontal disease or can serve as templates for peptide and peptide mimetics with improved therapeutic indices.

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Section: Regulation Of Antimicrobial Peptide Expressionmentioning

confidence: 99%

Antimicrobial peptides and periodontal disease

Gorr

Abdolhosseini

2011

J Clinic Periodontology

152

158

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show abstract

“…The cells may release CgA-LI into blood stream (endocrine secretion) in addition to salivary release (exocrine secretion). The endocrine exocrine secretion of the cells resembles the secretion of renin in the cells of juxtaglomerular apparatus and coagulating gland (17). In a recent study, the authors found similar concentrations of CgA in serum and saliva (18).…”

Section: Discussionmentioning

confidence: 87%

Plasma versus Salivary Chromogranin A as Selective Markers in Pheochromocytoma Diagnosis

Stefanescu¹,

Schipor²,

Păun³

et al. 2011

Acta Endo (Buc)

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“…Chromogranin A is a major soluble protein in adrenal medullary chromaffin granules and adrenergic neurons and is coreleased with catecholamines, which is considered to be a good index of sympathetic activity [13,14]. In particular, salivary CgA is reported to be a sensitive and substantial index of psychological stress, whereas it does not respond to physical stress [8].…”

Section: Discussionmentioning

confidence: 99%

“…Chromogranin A also exists in the submandibular gland and is secreted into saliva after stimulation of the sympathetic nervous system [14]. In particular, the CgA in this site responds to psychological stress but not to physical stress [8].…”

Section: Introductionmentioning

confidence: 99%