Salix subserrata Bark Extract-Loaded Chitosan Nanoparticles Attenuate Neurotoxicity Induced by Sodium Arsenate in Rats in Relation with HPLC–PDA-ESI–MS/MS Profile

Hamdan, Daila I.; Tawfeek, Nora; El-Shiekh, Riham A.; Khalil, Heba M. A.; Mahmoud, Mohamed Y.; Bakr, Alaa F.; Zaafar, Dalia; Farrag, Nawaal; Wink, Michaël; El-Shazly, Assem M.

doi:10.1208/s12249-022-02478-4

Cited by 13 publications

(7 citation statements)

References 86 publications

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“…The size of the nanoparticles was 340 nm at a CS/TPP w/w ratio of 4:1, but the size of the nanoparticles tends to increase at other CS/TPP ratios ( Zhang et al, 2004 ). These results align with what is typically seen in chitosan nanoparticles produced through the ionic gelation method ( Bugnicourt et al, 2014 ; Hamdan et al, 2023 ).…”

Section: Discussionsupporting

confidence: 88%

Inhibition of the Naja naja venom toxicity by polymeric nanoparticles loaded with Leucas aspera methanolic extract

Singh,

Jayaraman

2024

Front. Pharmacol.

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BackgroundSnakebite is a neglected tropical disease that affects millions of people worldwide. Developing effective treatments can make a significant contribution to global health efforts and public health initiatives. To reduce mortality due to snakebite, there is an immediate need to explore novel and effective treatment methodologies. In that context, nanoparticle-based drug delivery is gaining a lot of attention. Hydrophilic nanoparticles are suitable for the delivery of therapeutic peptides, proteins, and antigens.MethodsThe present investigation is aimed at evaluating the anti-ophidian potential of the methanolic extract of the ethno-medicinal herb Leucas aspera (Willd.) loaded within chitosan nanoparticles (CNP-LA), against the Indian cobra (Naja naja) venom enzymes. For this purpose, nanoparticles were prepared using the ionic gelation method to enhance the efficacy of the extract. The physicochemical and structural features of nanoparticles were investigated using dynamic light scattering (DLS), Fourier-transform Infrared (FTIR), field emission scanning electron microscopy (FE-SEM), and X-ray diffraction (XRD) techniques.ResultsIt was found that CNP-LA has an average size of 260 nm with a polydispersity index of 0.132 (PDI) and zeta potential of 34.7 mV, with an encapsulation efficiency of 92.46%. The in vitro release study was performed at pH 5.0 and 7.4. Furthermore, in vitro studies indicated that CNP-LA inhibited the phospholipase A2, hemolytic, and caseinolytic activities of Naja naja venom with the percentage inhibition of 92.5%, 83.9%, and 94.5%, respectively.ConclusionThis is the first report on the application of herbal methanolic extract loaded within chitosan nanoparticles for neutralizing snake venom enzymes with increased efficiency.

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Section: Discussionsupporting

confidence: 88%

Inhibition of the Naja naja venom toxicity by polymeric nanoparticles loaded with Leucas aspera methanolic extract

Singh,

Jayaraman

2024

Front. Pharmacol.

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“…Taken together, these results indicate that Pio administration either alone or with Cis has an anxiolytic-like effect in reducing the sickness behavior of ESC-bearing mice. Different studies were conducted on rodents to explore the sickness behavior of chemotherapeutic agents, including Cis and doxorubicin, and the possible augmenting role of plant-based therapy (Orabi et al, 2021;Hamdan et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

The Role of Pioglitazone Against Ehrlich Solid Carcinoma Mice Model Through Antiproliferative and Antiangiogenic Pathways

Zaafar¹,

Khalil²,

Hassanin³

et al. 2023

AAVS

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C ancer is the second prominent cause of death globally, also prevalence is expected to increase by 2040 due to the increase in the new cases of malignancy annually (Bray et al., 2018). Chemotherapeutic medications are extensively used in cancer treatment either alone or with radiotherapy and surgical interventions. Cisplatin, one of the antineoplastic alkylating agents, has a significant proven efficacy against many types of malignancies, such as the neck, ovaries, testes, and lung cancers (Al-Eitan et al., 2020). However, despite its substantial antineoplastic

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“…By catalyzing the dismutation of the superoxide anion into oxygen and hydrogen peroxide (H 2 O 2 ), which GPx then metabolizes, SOD is recognized as the rst member of the system of antioxidant defense (ZHEN et al, 2016) (Hamdan et al, 2022). Additionally, MDA is increasingly known as the most signi cant byproduct of the peroxidation of membrane lipids, making it a useful indirect marker of the degree of cell damage (Senn et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Combined β-Sitosterol and Trimetazidine mitigate potassium dichromate-induced cardiotoxicity in rats through the interplay between NF-κB/AMPK/mTOR/TLR4 and HO-1/NADPH signaling pathways

El-Shoura

Salem

Ahmed

et al. 2023

Preprint

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Hexavalent chromium salt, like potassium dichromate (PD), is chromium's most precarious valence state, present in industrial wastes. Recently, there has been increasing interest in β-sitosterol (BSS), a bioactive phytosterol, as a dietary supplement. BSS is recommended in treating cardiovascular disorders due to its antioxidant effect. Trimetazidine (TMZ) was used traditiovally for cardioprotection. Through the administration of BSS and TMZ, the cardiotoxic effects of PD were to be countered in this study, in addition to examining the precise mechanism of PD-induced cardiotoxicity. Thirty male albino rats were divided into five groups; the control group: administered normal saline daily (3 mL/kg); the PD group: administered normal saline daily (3 mL/kg); BSS group: administered BSS daily (20 mg/kg); TMZ group: administered TMZ daily (15 mg/kg). BSS+TMZ group: administered both BSS (20 mg/kg) and TMZ (15 mg/kg) daily. All experimental groups, except the control, received on the 19th day a single dose of PD (30 mg/kg/day, SC). Normal saline, BSS, and TMZ were received daily for 21 consecutive days orally. The exposure to PD promoted different oxidative stress, proinflammatory, and cardiotoxicity biomarkers. BSS or TMZ succeeded solely in reducing this deleterious effect; however, their combination notably returns measured biomarkers close to normal values. The histopathological investigations have supported the biochemical findings. The combination of BSS and TMZ protects against PD cardiotoxicity in rats by reducing oxidative stress and apoptotic and inflammatory biomarkers. It may be promising for alleviating and treating PD-induced cardiotoxicity in people at an early stage.

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Salix subserrata Bark Extract-Loaded Chitosan Nanoparticles Attenuate Neurotoxicity Induced by Sodium Arsenate in Rats in Relation with HPLC–PDA-ESI–MS/MS Profile

Cited by 13 publications

References 86 publications

Inhibition of the Naja naja venom toxicity by polymeric nanoparticles loaded with Leucas aspera methanolic extract

Inhibition of the Naja naja venom toxicity by polymeric nanoparticles loaded with Leucas aspera methanolic extract

The Role of Pioglitazone Against Ehrlich Solid Carcinoma Mice Model Through Antiproliferative and Antiangiogenic Pathways

Combined β-Sitosterol and Trimetazidine mitigate potassium dichromate-induced cardiotoxicity in rats through the interplay between NF-κB/AMPK/mTOR/TLR4 and HO-1/NADPH signaling pathways

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