Salting‐out of bio‐based 2,3‐butanediol from aqueous solutions

Xie, Shaoqu; Zhang, Yulei; Zhou, Yong; Wang, Zeru; Yi, Conghua; Qiu, Xueqing

doi:10.1002/jctb.4999

Cited by 40 publications

(24 citation statements)

References 31 publications

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“…5 b). These results were in agreement well with the previous investigation that proved the sequence of salting-out ability: K 4 P 2 O 7 > K 2 HPO 4 [ 29 ], which might be attributed to the Gibbs free energy of hydration of the ions (∆ hyd G ) [ 31 ]. In addition, at the salting-out factor of 3.0, 99.32 and 99.29% of total ABE could be recovered in the K 4 P 2 O 7 and K 2 HPO 4 groups, respectively.…”

Section: Resultssupporting

confidence: 92%

“…K 4 P 2 O 7 and K 2 HPO 4 behaved higher solubility accompany with the increase of temperature. Besides, the different salt concentrations also have a significant effect on the liquid–liquid equilibrium [ 27 ], and further affected the separation behaviors [ 26 – 29 ]. The saturated K 4 P 2 O 7 and K 2 HPO 4 solutions at different temperatures were added into the gas stripping condensate for the second-stage ABE separation, respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Compared with the groups of K 4 P 2 O 7 , the results in the K 2 HPO 4 groups were better for organics separation. However, the phenomenon was not inconsistent to the sequence of salting-out ability [ 29 ]. It was due to the different volumes of organic phase and aqueous phase.…”

Section: Resultsmentioning

confidence: 99%

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Integrated in situ gas stripping–salting-out process for high-titer acetone–butanol–ethanol production from sweet sorghum bagasse

Wen

Chen

Cai

et al. 2018

Biotechnol Biofuels

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BackgroundThe production of biobutanol from renewable biomass resources is attractive. The energy-intensive separation process and low-titer solvents production are the key constraints on the economy-feasible acetone–butanol–ethanol (ABE) production by fermentation. To decrease energy consumption and increase the solvents concentration, a novel two-stage gas stripping–salting-out system was established for effective ABE separation from the fermentation broth using sweet sorghum bagasse as feedstock.ResultsThe ABE condensate (143.6 g/L) after gas stripping, the first-stage separation, was recovered and introduced to salting-out process as the second-stage. K4P2O7 and K2HPO4 were used, respectively. The effect of saturated salt solution temperature on final ABE concentration was also investigated. The results showed high ABE recovery (99.32%) and ABE concentration (747.58 g/L) when adding saturated K4P2O7 solution at 323.15 K and 3.0 of salting-out factor. On this condition, the energy requirement of the downstream distillation process was 3.72 MJ/kg of ABE.ConclusionsHigh-titer cellulosic ABE production was separated from the fermentation broth by the novel two-stage gas stripping–salting-out process. The process was effective, which reduced the downstream process energy requirement significantly.Electronic supplementary materialThe online version of this article (10.1186/s13068-018-1137-5) contains supplementary material, which is available to authorized users.

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Section: Resultssupporting

confidence: 92%

Section: Resultsmentioning

confidence: 99%

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Integrated in situ gas stripping–salting-out process for high-titer acetone–butanol–ethanol production from sweet sorghum bagasse

Wen

Chen

Cai

et al. 2018

Biotechnol Biofuels

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“…In these studies, salt acts positively on extraction but it may adversely affect the distillation operation during the recovery of solvent. Recycling may have some solid particles, which can cause scaling or blockage; salt also appears in the raffinate phase, which means solvent and salt recovery will be performed separately and will account for additional cost [ 36 ]. Therefore, the reliable option for commercializing solvent extraction is to use a solvent (without salt addition) with high selectivity and distribution coefficient for 2,3-BDO.…”

Section: Introductionmentioning

confidence: 99%

Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis

Harvianto

Haider

Jiang

et al. 2018

Biotechnol Biofuels

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Background2,3-Butanediol (2,3-BDO) is a synthetic chemical compound that also can be produced by biomass fermentation, which is gaining share in the global market as an intermediate product for numerous applications, i.e. as liquid fuel or fuel additive. Several metabolic engineering fermentation strategies to enhance the production of 2,3-BDO were developed. However, the recovery of 2,3-BDO from its fermentation broth remains a challenge due to its low concentration and its solubility in water and other components. Thus, a cost-effective recovery process is required to deliver the required purity of 2,3-BDO. This paper presents a new process development and techno-economic analysis for 2,3-BDO purification from a fermentation broth.ResultsConventional distillation and hybrid extraction-distillation (HED) processes are proposed in this study with detailed optimization and economic analysis. Particularly, a systematic solvent selection method was successfully implemented to determine a good solvent for the proposed HED configuration based on numerous experimental data obtained with each solvent candidate. NRTL and UNIQUAC property methods were evaluated to obtain binary interaction parameters of 2,3-BDO through rigorous Aspen Plus regression and validated using experimental data. Total annual cost (TAC)-based optimization was performed for each proposed configuration. Even though the HED configuration required 9.5% higher capital cost than conventional distillation, placing an extraction column before the distillation column was effective in removing water from the fermentation broth and significantly improved the overall process economics.ConclusionsOleyl alcohol was found to be the most suitable solvent for the HED of 2,3-BDO due to its high distribution coefficient and high selectivity. The proposed HED drastically reduced reboiler duty consumption and TAC by up to 54.8 and 25.8%, respectively. The proposed design is expected to be used for the commercial scale of 2,3-BDO production from fermentation process.Electronic supplementary materialThe online version of this article (10.1186/s13068-018-1013-3) contains supplementary material, which is available to authorized users.

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“…wileyonlinelibrary.com/jctb Our previous research has shown that the molality of salt in the aqueous phase had a linear relationship with the solubility of 2, 3-butanediol in the aqueous phase in the experiment of salting-out 2, 3-butanediol, and the linear solubility correlation between the two parameters was built. 38 In this work, the same solubility correlation was employed in the SOE systems of isobutanol to evaluate the effect of salt on the recovery efficiency.…”

Section: The Solubility Correlationmentioning

confidence: 99%

Salting‐out extraction of bio‐based isobutanol from an aqueous solution

Zhang

Xie

et al. 2017

J of Chemical Tech & Biotech

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BACKGROUND More efficient downstream separation technologies need to be explored due to the low concentration of bio‐based isobutanol in the fermentation broth. The salting‐out extraction of isobutanol from its aqueous solution by employing nine salts (K4P2O7·3H2O, K2HPO4·3H2O, K3PO4·3H2O, K2CO3, K2SO4, KCl, Na2CO3, Na2SO4, NaCl) as salting‐out agents and three organic solvents (2‐ethyl‐1‐hexanol, cyclopentanol, 2‐methyl‐2‐butanol) as extractants were investigated at 298.15 K. RESULTS The recovery was greatly influenced by the salt concentration and types of salts and organic solvents. When the initial molar K4P2O7 concentration was equal to or higher than 1.01 mol kg‐1 and the mass ratio of aqueous isobutanol solution to 2‐ethyl‐1‐hexanol was 1:1, the recovery of isobutanol reached 100%, and more than 91.62% of water was removed from the organic phase. CONCLUSION The salting‐out effects of different anions in nine salts were ordered in the sequence: Cl‐ < SO42‐ < HPO42‐ < CO32‐ < PO43‐ < P2O74‐ at the same initial molar salt concentration and using the same organic solvent. 2‐Ethyl‐1‐hexanol was verified to be the most suitable extractant. The distribution behavior and salting‐out extraction effects can be evaluated by tie‐line correlations and solubility correlation. © 2017 Society of Chemical Industry

show abstract

Salting‐out of bio‐based 2,3‐butanediol from aqueous solutions

Cited by 40 publications

References 31 publications

Integrated in situ gas stripping–salting-out process for high-titer acetone–butanol–ethanol production from sweet sorghum bagasse

Integrated in situ gas stripping–salting-out process for high-titer acetone–butanol–ethanol production from sweet sorghum bagasse

Purification of 2,3-butanediol from fermentation broth: process development and techno-economic analysis

Salting‐out extraction of bio‐based isobutanol from an aqueous solution

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