Sarcopenia as a comorbidity of cardiovascular disease

Sasaki, Ken-ichiro

doi:10.1016/j.jjcc.2021.10.013

Cited by 55 publications

(34 citation statements)

References 143 publications

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“…In fact, the muscular and cardiovascular systems do not stand isolated one from each other, since interactions in the course of aging between both systems seem to occur. Indeed, sarcopenia is more prevalent among cardiovascular disease (CVD) patients and is related to markers of vascular health such as arterial stiffness and coronary artery calcifications [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

Assar

Álvarez‐Bustos

Sosa

et al. 2022

IJMS

134

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Functional status is considered the main determinant of healthy aging. Impairment in skeletal muscle and the cardiovascular system, two interrelated systems, results in compromised functional status in aging. Increased oxidative stress and inflammation in older subjects constitute the background for skeletal muscle and cardiovascular system alterations. Aged skeletal muscle mass and strength impairment is related to anabolic resistance, mitochondrial dysfunction, increased oxidative stress and inflammation as well as a reduced antioxidant response and myokine profile. Arterial stiffness and endothelial function stand out as the main cardiovascular alterations related to aging, where increased systemic and vascular oxidative stress and inflammation play a key role. Physical activity and exercise training arise as modifiable determinants of functional outcomes in older persons. Exercise enhances antioxidant response, decreases age-related oxidative stress and pro-inflammatory signals, and promotes the activation of anabolic and mitochondrial biogenesis pathways in skeletal muscle. Additionally, exercise improves endothelial function and arterial stiffness by reducing inflammatory and oxidative damage signaling in vascular tissue together with an increase in antioxidant enzymes and nitric oxide availability, globally promoting functional performance and healthy aging. This review focuses on the role of oxidative stress and inflammation in aged musculoskeletal and vascular systems and how physical activity/exercise influences functional status in the elderly.

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Section: Introductionmentioning

confidence: 99%

Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

Assar

Álvarez‐Bustos

Sosa

et al. 2022

IJMS

134

View full text Add to dashboard Cite

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“…33 These factors are considered to be underlying causes of HFpEF development and have emerged as potential therapeutic targets. 34 In a cross-sectional study, diastolic dysfunction was observed more frequently in community-dwelling older adults with sarcopenia than in older adults without sarcopenia. 35 In the present study, 72.6% of patients had a preserved LVEF ≥50% at discharge.…”

Section: Discussionmentioning

confidence: 97%

Physical Frailty May Predict 2-Year Prognosis in Elderly Patients With Acute Myocardial Infarction　― A Report From the FLAGSHIP Study ―

Ashikawa

Adachi

Iwatsu

et al. 2023

Circ J

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Background: Elderly patients with acute myocardial infarction (AMI) are a high-risk population for heart failure (HF), but the association between physical frailty and worsening prognosis, including HF development, has not been documented extensively. Methods and Results:As part of the FLAGSHIP study, we enrolled 524 patients aged ≥70 years hospitalized for AMI and capable of walking at discharge. Physical frailty was assessed using the FLAGSHIP frailty score. The primary outcome was a composite outcome of all-cause death and HF rehospitalization within 2 years after discharge. The secondary outcome was all-cause death and HF rehospitalization. After adjusting for confounders, physical frailty showed a significant association with an increased risk of the composite outcome (hazard ratio [HR]=2.09, 95% confidence interval [CI]: 1.03-4.22, P=0.040). The risk of HF rehospitalization increased with physical frailty, but the association was not statistically significant (HR=2.14, 95% CI: 0.84-5.44, P=0.110). Physical frailty was not associated with an increased risk of all-cause death (HR=1.45, 95% CI: 0.49-4.26, P=0.501). Conclusions:The findings suggest that physical frailty assessment serves as a stratifying tool to identify high-risk populations for post-discharge clinical events among ambulant elderly patients with AMI.

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“…HGS could be a useful marker of the poor prognosis in daily clinical settings. lowering of muscle blood flow caused by cardiac disease, and physical inactivity due to chest symptoms contribute to sarcopenia 27) . Conversely, sarcopenia affects cardiac disease.…”

Section: Discussionmentioning

confidence: 99%

Impact of Handgrip Strength on Clinical Outcomes after Percutaneous Coronary Intervention

Tobe

Tanaka

Shirai

et al. 2023

JAT

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Aim: The relationship between handgrip strength (HGS) and clinical outcomes after percutaneous coronary intervention (PCI) has not yet been thoroughly investigated.Methods: This was a single-center, observational study. A total of 469 patients who underwent PCI and whose periprocedural HGS was measured were included. Patients were divided into two groups: the low HGS group (men, ＜28 kg; women, ＜18 kg) and the high HGS group (men, ≥ 28 kg; women, ≥ 18 kg). The primary outcome was the composite endpoint of all-cause death, myocardial infarction (MI), and heart failure readmission. Results: There were 151 patients in the low HGS group and 318 patients in the high HGS group. The age of patients in the low HGS group was significantly higher (median [interquartile range]: 78 [71-82] vs. 70 [61-75] years, p＜0.001), while the body mass index and serum albumin level were significantly lower (body mass index: 22.

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Sarcopenia as a comorbidity of cardiovascular disease

Cited by 55 publications

References 143 publications

Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

Physical Frailty May Predict 2-Year Prognosis in Elderly Patients With Acute Myocardial Infarction　― A Report From the FLAGSHIP Study ―

Impact of Handgrip Strength on Clinical Outcomes after Percutaneous Coronary Intervention

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Sarcopenia as a comorbidity of cardiovascular disease

Cited by 55 publications

References 143 publications

Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging

Physical Frailty May Predict 2-Year Prognosis in Elderly Patients With Acute Myocardial Infarction ― A Report From the FLAGSHIP Study ―

Impact of Handgrip Strength on Clinical Outcomes after Percutaneous Coronary Intervention

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Physical Frailty May Predict 2-Year Prognosis in Elderly Patients With Acute Myocardial Infarction　― A Report From the FLAGSHIP Study ―