SARS-CoV-2 vaccine challenge based on spike glycoprotein against several new variants

Syahniar, Rike; Kharisma, Dayu Swasti

doi:10.7774/cevr.2022.11.2.173

Cited by 3 publications

(3 citation statements)

References 64 publications

(108 reference statements)

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“…Moreover, the failure rate in most of these clinical studies is probably underestimated as many COVID-19 infections are asymptomatic. This is more particularly evident for the new Omicron variant that displays a much more important immune escape rate [5,6]. Thus the most important evidence-based argument for these COVID-19 vaccines remains the prevention of severe clinical forms of the disease [7].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 Preoperative Blood Tests : What Do They Tell Us About COVID-19 Vaccines?

Dupoirieux¹

2023

Med Clin Sci

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This observational real-world study was conducted on 14 patients who needed a minor office surgery or procedure and who were eligible for a COVID-19 booster according to the French Health Agency. The aim of the study was focused on biological markers which might have an incidence after surgery. The platelet count, D-dimer level, and anti-spike IgG antibodies levels, were the numeric parameters studied. The study showed no perturbation in the platelet count. Conversely, we observed an abnormal elevation of D-dimer levels in 4 patients (28 %). The most remarkable data was the constant residual positive level anti-spike IgG antibodies observed in all patients after 6 months ranging from 44 to 5680 BAU/mL. For these reasons, further studies on a bigger cohort would be useful to clarify the possible incidence of COVID-19 vaccines on D-dimer levels and a monitoring of the immune response should be proposed to all patients eligible for a SARS-CoV-2 vaccine booster in order to evaluate the benefit-risk ratio of this injection.

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Section: Discussionmentioning

confidence: 99%

COVID-19 Preoperative Blood Tests : What Do They Tell Us About COVID-19 Vaccines?

Dupoirieux¹

2023

Med Clin Sci

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“…Vaccination is an important strategy in controlling the COVID-19 pandemic by reducing disease severity and limiting infection [7], [8]. Recommendations from the Society for Maternal-Fetal Medicine and the American College of Obstetricians and Gynecologists (ACOG) have stated that the vaccine should be offered to pregnant and lactating women based on risk [7]- [9].…”

Section: Introductionmentioning

confidence: 99%

Factors associated with the willingness to receive COVID-19 vaccination among pregnant women

Jaelani

Syahniar²

2023

IJPHS

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Pregnant women are a vulnerable group to be infected by COVID-19, and have a higher risk of serious illness, morbidity, and mortality than the general population. Willingness to receive COVID-19 vaccination has a decisive role in successfully controlling the COVID-19 pandemic. The objective of this study was to determine the factors related to the willingness to get COVID-19 vaccination in pregnant women at the Teluknaga Public Health Center. A total of 102 pregnant women with gestational ages of 13 to 33 weeks were selected by convenience sampling. Data were collected by filling out a questionnaire during November to December 2021. All respondents had a health status that meets the requirements for COVID-19 vaccination. Overall, 63% of pregnant women wanted to receive COVID-19 vaccination. There were significant relationships between education (p=0.029), frequency of antenatal care (p=0.019), husband's support (p<0.001) and willingness to receive vaccination. Religion, occupation, knowledge about COVID-19, parity, frequency of antenatal care visits, and sources of information did not show significant relationships with the willingness to receive COVID-19 vaccination among them. Education and awareness campaigns about the safety of the COVID-19 vaccine for pregnant women and the role of health workers are needed to raise awareness.

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“…This infection starts with a virus that enters via the Angiotensin Converting Enzyme-2 or ACE2 receptor (1,3). These receptors are not only owned by the lungs but also by other organs such as the kidneys, bladder, ileum, and heart (4) The blockage of these receptors by the Coronavirus means that angiotensin II cannot be converted to angiotensin 1-7, increasing the amount of angiotensin II.…”

Section: Introductionmentioning

confidence: 99%

Clinical Characteristics of Acute Kidney Injury in Covid-19 Patients

Nisrina,

Wibowo

2023

MMJ

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Background: Coronavirus Disease 2019 (COVID-19) is one of the infectious diseases that exist in Indonesia. Not only infects the lungs, but this virus can also infect other organs such as the kidneys. In addition, the process of viral infection causes cell hypermetabolism, which can increase the workload of the kidneys in excreting metabolic waste. In the end, the damage caused by the virus can cause Acute Kidney Injury (AKI). It is necessary to know the prevalence and characteristics of this event. Purposes: This study aims to provide an overview of AKI's prevalence and clinical features in COVID-19 patients. Methods: This was a descriptive study that used patient medical records for the period April-September 2021. The univariate analysis data showed a characteristic frequency distribution of age, gender, comorbidity, hospitalization duration, and urea creatinine rate. Results: The incoming samples based on the inclusion and exclusion criteria were 44 samples. In COVID-19 patients, complications of AKI were found in adults, as much as 68.2% of both men and women had a percentage of 50%, the most common comorbid was hypertension 30.8% with a hospitalization duration of 1-10 days 43.2% and an average increase in urea 79.68 mg/dL and creatinine average 2,859 mg/dL. Conclusion: Based on patient characteristics, the results showed that more COVID-19 patients with acute kidney injury complications occurred in adult patients, with no difference in prevalence between males and females, with comorbid hypertension and length of hospitalization less than ten days.

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SARS-CoV-2 vaccine challenge based on spike glycoprotein against several new variants

Cited by 3 publications

References 64 publications

COVID-19 Preoperative Blood Tests : What Do They Tell Us About COVID-19 Vaccines?

COVID-19 Preoperative Blood Tests : What Do They Tell Us About COVID-19 Vaccines?

Factors associated with the willingness to receive COVID-19 vaccination among pregnant women

Clinical Characteristics of Acute Kidney Injury in Covid-19 Patients

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