The coronavirus disease (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has infected more than 26 million individuals and caused 871,166 deaths globally. Various countries are racing against time to find a vaccine for controlling the rapid transmission of infection. The selection of antigen targets to trigger an immune response is crucial for vaccine development strategies. The receptor binding domain of the subunit of spike 1 protein is considered a promising vaccine candidate because of its ability to prevent attachment and infection of host cells by stimulating neutralizing antibodies. The vaccine is expected to mount a sufficient immunogenic response to eliminate the virus and store antigenic information in memory cells for long-term protection. Here, we review the ongoing clinical trials for COVID-19 vaccines and discuss the immune responses in patients administered an adequate dosage to prevent COVID-19.

Pregnant women are a vulnerable group to be infected by COVID-19, and have a higher risk of serious illness, morbidity, and mortality than the general population. Willingness to receive COVID-19 vaccination has a decisive role in successfully controlling the COVID-19 pandemic. The objective of this study was to determine the factors related to the willingness to get COVID-19 vaccination in pregnant women at the Teluknaga Public Health Center. A total of 102 pregnant women with gestational ages of 13 to 33 weeks were selected by convenience sampling. Data were collected by filling out a questionnaire during November to December 2021. All respondents had a health status that meets the requirements for COVID-19 vaccination. Overall, 63% of pregnant women wanted to receive COVID-19 vaccination. There were significant relationships between education (p=0.029), frequency of antenatal care (p=0.019), husband's support (p<0.001) and willingness to receive vaccination. Religion, occupation, knowledge about COVID-19, parity, frequency of antenatal care visits, and sources of information did not show significant relationships with the willingness to receive COVID-19 vaccination among them. Education and awareness campaigns about the safety of the COVID-19 vaccine for pregnant women and the role of health workers are needed to raise awareness.

BACKGROUND: The high infection of methicillin-resistant Staphylococcus aureus (MRSA) accompanied by increased resistance to many groups of antibiotics is a major concern in the field of infection. This study aims to evaluate the prevalence of MRSA isolates and antimicrobial susceptibility to MRSA isolates in Indonesia. METHODS: We did searches in Pubmed, Proquest, DOAJ, GARUDA, and google scholar for studies published in 2006-2020. Study in Indonesian (Bahasa) and English with the keywords "methicillin-resistant Staphylococcus aureus", "MRSA" and "Indonesia". More than 30 S.aureus isolates derived from human samples were included. RESULTS: A total of 738 articles based on the search results, 13 studies were included in this systematic review. The prevalence of MRSA reported from all studies is 0.3%-52%. The study with the largest prevalence of MRSA was found in Jakarta. The susceptibility of vancomycin antibiotics to MRSA isolates is known to range from 87%-100%. Based on all studies, Linezolid, Tigecycline, Nitrofurantoin, and quinupristin/dalfopristin were reported to have 100% susceptibility. CONCLUSIONS: The prevalence of MRSA is still found high in one of the cities in Indonesia. Surveillance of antibiotic use, monitoring of antimicrobial susceptibility patterns, and antibiotic resistance control programs need to be optimized. MRSA screening is based on a rapid diagnosis when an inpatient admission is also necessary.

Latar Belakang: Air susu ibu (ASI) mengandung mikrobiota dalam jumlah banyak yang mewakili bakteri komensal, mutualistik, dan bakteri yang berpotensi sebagai probiotik pada saluran cerna bayi. Hasil: Filum bakteri yang paling dominan dalam ASI antara lain Proteobacteria dan Firmicutes sedangkan pada tingkat genus yaitu Staphylococcus, Pseudomonas, Streptococcus dan Lactobacillus. Diantara berbagai mikrobiota yang terdapat dalam ASI, Lactobacillus dan Bifidobacterium berpotensi sebagai probiotik. Kesimpulan: Mikrobiota usus memberikan fungsi metabolisme, dan proteksi yang bermanfaat seperti peningkatan kapasitas pencernaan, produksi asam lemak rantai pendek dan vitamin, pengaturan struktur mukosa dan sistem kekebalan tubuh serta resistensi kolonisasi terhadap patogen.

Helicobacter pylori infect during childhood and are typically present for life, despite a vigorous host immune response, which includes the invading pathogen being coated with antibodies. This bacterial longevity indicates the development, on the part of the pathogen, of a range of processes for evading effective host immunity. Since its discovery 25 years ago, significant progress has been made in understanding the virulence factors and several aspects of the pathogenesis of H. pylori gastric diseases. The prevalence of antimicrobial drug resistance is so high that all patients infected with H. pylori should be considered resistant infections. The most severe consequence of H. pylori infection, and the key reason a vaccine is required, is gastric cancer, globally the third leading cause of death due to cancer. Patients typically present with gastric cancer without knowing they are infected; eradication likely has little effect by this time. Vaccine against H. pylori that reduces the incidence of gastric cancer will probably be cost effective in developed countries. Several vaccines were successfully tested in different experimental animal models, but translation into an efficacious human vaccine has been unsuccessful.