Saussurea Lappa Modulates Gastrointestinal Motility, Motilin and Cholecystokinin Expression in Ulcer Rats

Abstract

cholecystokinin and motilin secretion decrease. Similarity to Omeprazole, S. lappa accelerated the coalescence of ethylic acidinduced duodenal ulcer significantly (p < 0.01, vs model group), but no obvious dose-dependent effect was found. S. lappa also improved gastrointestinal myoelectric activity and accelerated intestinal propulsion. Furthermore, S. lappa could increase the expression levels of cholecystokinin and motilin in duodenum and increase motilin level in serum. CONCLUSION: S. lappa can accelerate the coalescence of chronic duodenal ulcer, and increase gastrointestinal myoelectric activity and the expression of cholecystokinin and motilin in duodenum.