Abstract. Model uncertainty is a significant challenge in the wind energy industry and can lead to mischaracterization of millions of dollars' worth of wind resource. Machine learning methods, notably deep artificial neural networks (ANNs), are capable of modeling turbulent and chaotic systems and offer a promising tool that can be used to produce high-accuracy wind speed forecasts and extrapolations. This paper quantifies the role of domain knowledge on ANN wind speed extrapolation accuracy using data collected using profiling lidars over three field campaigns. A series of 11 meteorological features are used as ANN inputs and the resulting output accuracy is compared with that of a simple power law extrapolation. It is found that normalized inputs, namely turbulence intensity, normalized current wind speed, and normalized previous wind speed, are the features that most reliably improve ANN accuracy, providing up to a 52 % increase in extrapolation accuracy over the power law predictions. The volume of input data is also deemed important for achieving robust results. One test case is analyzed in-depth using dimensional and non-dimensional features, showing that feature normalization drastically improves network accuracy and robustness for uncommon atmospheric cases.