Scavenging Activity of Diclofenac: Interaction With Abts Radical Cation and Peroxyl Radicals

Rojo, C; Álvarez-Figueroa, María Javiera; Soto, Macarena; Cañete, Álvaro; Pessoa‐Mahana, C. David; López-Alarcón, Camilo

doi:10.4067/s0717-97072009000100014

Cited by 7 publications

(5 citation statements)

References 13 publications

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“…Medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used in the management of acute inflammation. Diclofenac (2-[(2,6-dichlorophenyl)amino] benzenacetic acid), a well-known NSAID drug, exerts its anti-inflammatory effects through the inhibition of the arachidonate metabolites synthesis secondary to cyclooxygenase (COX) inhibition [ 8 ]. Diclofenac was observed to possess dose–response relationships for COX-2 and COX-1 inhibition, with greater COX-2 selectivity [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Ginger (Zingiber officinale) Root Capsules Enhance Analgesic and Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation

et al. 2023

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Our study aimed to evaluate the analgesic and antioxidant effects of ginger (Zingiber officinale) root capsule extract (GRCE) in addition to diclofenac (D) sodium treatment in carrageenan-induced acute inflammation (AI). Seven groups of eight Wistar-Bratislava white rats were included in the study. One group was the control (C), and AI was induced in the other six groups. The following treatments were applied: saline solution for C and AI groups, D for the AID group, GRCE for two groups and GRCE and D for another two groups. The GRCE was administered by gavage in two doses (100 mg/Kg b.w. or 200 mg/kg b.w.), while D was administered intraperitoneally in a dose of 5 mg/kg b.w. The association of GRCE with this low dose of diclofenac reduced pain threshold and improved mobility with the best results for the dose of 200 mg/kg b.w. Moreover, this combination reduced, better than D alone, the serum levels of the evaluated pro-oxidant parameters (malondialdehyde, the indirect assessment of NO synthesis, total oxidative status and oxidative stress index) up to 78%, especially oxidative stress index (p < 0.0001). GRCE alone slightly improved the antioxidant parameters (total antioxidant capacity and total thiols), but when associated with, D the results were better, especially for total thiols as their plasma levels increased up to 50% (p < 0.0010), with the best results obtained for the 200 mg/kg b.w. dose of GRCE. In conclusion, ginger root capsules associated with diclofenac might offer additional antioxidant and analgesic effects in a dose-dependent manner in acute inflammation.

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Section: Introductionmentioning

confidence: 99%

Ginger (Zingiber officinale) Root Capsules Enhance Analgesic and Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation

et al. 2023

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“…Diclofenac (2-[(2,6-dichlorophenyl)amino] benzenacetic acid), widely used in clinical practice, is a synthetic NSAID employed in the treatment of different pathologies associated with inflammation processes, such as acute arthritis, acute lumbago, and migraine [ 8 ]. The mechanism of action is related to the inhibition of the arachidonate metabolites synthesis through cyclooxygenase inhibition [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin Nanoparticles Enhance Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation

Boarescu

Pop

et al. 2021

Biomedicines

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We investigated the in vivo effect of curcumin nanoparticles (nC) in addition to diclofenac sodium on local edema and oxidative stress parameters in carrageenan-induced paw edema on rats. Seven groups were investigated: control group (C), the acute inflammation (AI) group, an AI group treated with Diclofenac (AID, 5 mg/kg b.w. Diclofenac sodium), two AI groups treated with cC (conventional Curcumin)—AIC200 and AIcC200D (D = Diclofenac, 200 represent the concentration of active substance expressed in mg/kg b.w.), and two AI groups with nC (Curcumin nanoparticles)—AIC200 and AIcC200D. Serum and tissue oxidative stress was assessed by measuring five parameters. Curcumin nanoparticles alone and in combination with D better reduced the paw edema than D alone (p < 0.027). The rats treated with D and nC (AIcC200D) had the highest inhibition percentage on edema, reaching the maximum level of inhibition (81%) after 24 h. Conventional curcumin and nC presented antioxidant effects in acute inflammation, with significantly better results obtained for nC. The pro-oxidant markers were reduced up to 0.3 by the cC and up to 0.4 times by the nC and both solutions increased the antioxidant markers up to 0.3 times. The nC enhanced the antioxidative efficacy of D, as this combination reduced the pro-oxidant markers up to 1.3 times. Curcumin nanoparticles could represent a therapeutic option in association with classical nonsteroidal anti-inflammatory medication in acute inflammation, as they might offer a reduction of drug dose and possible limitation of their associated side effects.

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“…Besides its use in pathological processes related to inflammation, diclofenac and its chemical derivatives have been thoroughly investigated for a wide range of pharmacological effects . Several scientific communications report the broad‐spectrum antibacterial activity of diclofenac in vitro and in vivo against isolates of various gram‐positive and gram‐negative bacteria that were either sensitive or resistant to antibiotics .…”

Section: Introductionmentioning

confidence: 99%

Diclofenac‐Based Hydrazones and Spirothiazolidinones: Synthesis, Characterization, and Antimicrobial Properties

Kocabalkanli

Cihan-Üstündağ

Naesens

et al. 2017

Archiv der Pharmazie

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We report here the synthesis, structural characterization, and biological evaluation of novel diclofenac-based hydrazone (4a-f) and spirothiazolidinone (5a-f, 6a-f) derivatives designed as potential antimicrobial agents. The compounds were evaluated in vitro for their antiviral activity against a wide spectrum of DNA and RNA viruses. They were further screened in vitro against different strains of bacteria and fungi. The hydrazone derivatives, 4a and 4c-f, were found to be active against herpesviruses (HSV-1, HSV-2, and HSV-1 TK ), vaccinia virus, and Coxsackie B4 virus, with EC values between 6.6 µg/mL and 14.7 μg/mL, and the selectivity index values were greater than 10 for 4a and 4f. The newly synthesized compounds (4-6) were inactive against the bacterial and the fungal strains tested, at levels below 2500, 1250, or 625 μg/mL. Interestingly, the key intermediate 3 with a free hydrazide moiety displayed antifungal properties against Candida albicans and C. parapsilosis at MIC values of 4.88 µg/mL and 78.12 μg/mL, respectively.

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Scavenging Activity of Diclofenac: Interaction With Abts Radical Cation and Peroxyl Radicals

Cited by 7 publications

References 13 publications

Ginger (Zingiber officinale) Root Capsules Enhance Analgesic and Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation

Ginger (Zingiber officinale) Root Capsules Enhance Analgesic and Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation

Curcumin Nanoparticles Enhance Antioxidant Efficacy of Diclofenac Sodium in Experimental Acute Inflammation

Diclofenac‐Based Hydrazones and Spirothiazolidinones: Synthesis, Characterization, and Antimicrobial Properties

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