Scavenging effects of Mallotus repandus on active oxygen species

Lin, Jer-Min; Lin, Chun‐Ching; Chen, Mingfeng; Ujiie, Takashi; Takada, Atsushi

doi:10.1016/0378-8741(95)01246-a

Cited by 40 publications

(28 citation statements)

References 23 publications

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“…Any compound natural or synthetic with antioxidant activities might contribute towards the total or partial alleviation of this damage. Therefore removing superoxide and hydroxyl radicals is the most effective defence of a living body against diseases (Jer-Min Lin et al, 1995). Thus the results of our study show that TCREt possesses an antioxidant activity, which could exert a beneficial action against pathological alterations caused by the presence of superoxide and hydroxyl radicals in alloxan diabetes.…”

Section: Discussionmentioning

confidence: 69%

Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats

Prince

Menon

2001

Phytotherapy Research

125

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Tinospora cordifolia is widely used in Indian Ayurvedic medicine for the treatment of diabetes mellitus. Oral administration of 2.5 g and 5.0 g/kg body weight of the aqueous extract of the roots for 6 weeks resulted in a significant reduction in thiobarbituric acid reactive substances (TBARS) and an increase in reduced glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD) in alloxan diabetic rats. The effect of Tinospora cordifolia root extract (TCREt) was most prominently seen in the case of rats given 5.0 g/kg body weight. The effect of TCREt was more effective than glibenclamide. Thus our study shows that TCREt exhibits antioxidant action in alloxan diabetes.

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Section: Discussionmentioning

confidence: 69%

Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats

Prince

Menon

2001

Phytotherapy Research

125

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“…The product, a spin adduct (DMPO-OOH), was analyzed using an ESR spectrometer. [24][25][26] Solutions of 2.0 mM hypoxanthine/PBS (A), 5.5 mM DETAPAC (B), various concentrations of tested extracts or superoxide dismutase (SOD) (C) and 0.4 unit/ml of xanthine oxidase/PBS (D) were prepared before use. Solution D was stored in an ice bath to prevent any inactivation of the enzyme.…”

Section: Antioxidant and Free Radical Scavenging Activities Of Terminmentioning

confidence: 99%

Antioxidant and Free Radical Scavenging Activities of Terminalia chebula

Cheng

Lin

et al. 2003

Biological & Pharmaceutical Bulletin

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217

125

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“…The decoction was concentrated under reduced pressure and lyophilized to yield 26.53 g of MeOH extract. 16.49 g of MeOH extract was resuspended in 500 ml H 2 O and then extracted successively with CHCl 3 , EtOAc and n-butanol. The final yield of CHCl 3 , EtOAc and n-butanol extracts was 3.47, 2.16 and 3.90 g, respectively.…”

Section: Preparation Of Extractmentioning

confidence: 99%

“…The product, spin adduct (DMPO-OOH), was analyzed using an electron spin resonance (ESR) spectrometer [10,16,20]. Solutions of 2.0 mM HPX/ PBS (A), 5.5 mM DETAPAC (B), various concentrations of test extracts or SOD (C) and 0.4 unit/ml XOD/PBS (D) were prepared before use.…”

Section: Superoxide Anion and Hydroxyl Radical Scavenging Activitymentioning

confidence: 99%

Antioxidant and Antiviral Activities of <i>Euphorbia thymifolia </i>L.

et al. 2002

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The antioxidant and antiviral activities of Euphorbia thymifolia L. (Euphorbiaceae) were investigated in this study. The results showed that all of the fractions (MeOH, CHCl₃, EtOAc, n-butanol and water) and pure compounds (3-O-galloyl-4,6-(S)-HHDP-D-glucose, rugosin B and 1,3,4,6-tetra-O-galloyl-K-β-D-glucose)tested possessed antioxidant activities, with the exception of the organic aqueous fraction in the anti-lipid and anti-superoxide formation assays. The range of IC₅₀ of anti-lipid formation, anti-superoxide formation and free radical scavenging assays for all fractions and pure compounds were 2.81–7.63, 0.03–2.18 and 0.013–2.878 mg/ml, respectively. Electron spin resonance studies showed that water extract and pure compounds of E. thymifolia exhibited superoxide radical and hydroxyl radical scavenging activities. Besides antioxidant activities, 3-O-galloyl-4,6-(S)-HHDP-D-glucose and EtOAc fractionalso showed anti-HSV-2 activity. Thus, E. thymifolia was concluded to possess antioxidant and anti-HSV-2 activities.

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Scavenging effects of Mallotus repandus on active oxygen species

Cited by 40 publications

References 23 publications

Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats

Antioxidant action of Tinospora cordifolia root extract in alloxan diabetic rats

Antioxidant and Free Radical Scavenging Activities of Terminalia chebula

Antioxidant and Antiviral Activities of <i>Euphorbia thymifolia </i>L.

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