Scavenging of Free Radicals Generated in Biological Tissues Exposed to Ionizing Radiation Using Silver Nanoparticles

Abstract

Humans are exposed to nuclear radiations every day, and these radiations are both natural and artificial. When the body tissues are exposed to nuclear radiation, free radicals are formed, which are responsible for cancer development. In this research, silver nanoparticles were synthesized by electrical explosion wire method. Nanoparticles were added to deionized water that contained free radicals before and after exposure to gamma rays. The obtained results indicate that the silver nanoparticles have antioxidant potential through possessing free radical scavenging activity, as they can donate electron to free radicals and become neutralize. Then, these nanoparticles were injected to mice before and after their irradiation with gamma ray. The liver and kidney of the mice were shown to be unaffected by gamma irradiation.

Gamma Radiation Effect on Characterizations of Gold Nanoparticles Synthesized Using Green Method

“…The shape, size, surface area distribution, and aggregation of nanoparticles must all be determined before toxicity or biocompatibility can be determined [7]. The main benefit of plant extracts is that they are gentle, renewable, and non-toxic reducing and stabilizing agents, obviating the need for chemical reducing agents as well as costly polymeric capping agents and stabilizers [8,9]. Gold nanoparticles prepared by green method are more efficient than all other nanoparticles due to their considerable plasmon resonance and bioconjugation behavior with bimolecular medium [10].…”