Schwann-Cell Abnormalities in Diabetic Neuropathy

Thomas, P. K.; Lascelles, R. G.

doi:10.1016/s0140-6736(65)92154-9

Cited by 127 publications

(45 citation statements)

References 7 publications

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“…Case 7 shows extremely short internodes for any given fibre size. This was presumably the result of radiation given to the region of the spinal column and may reflect regeneration of fibres which had undergone Wallerian degeneration (Fullerton et al, 1965; Thomas and Lascelles, 1965). Autonomic function was not tested in this case.…”

Section: Resultsmentioning

confidence: 94%

“…It has been shown that fibres that regenerated after Wallerian degeneration showed uniformly short internodes for fibre size and those that had undergone segmental demyelination and remyelination showed internodes of normal and reduced lengths (Fullerton et al, 1965;Thomas and Lascelles, 1965). Figure 7 shows that both uniformly short internodes and internodes of varying length can be found on any one fibre, particularly in older subjects.…”

Section: Resultsmentioning

confidence: 96%

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Myelinated fibres in the human paravertebral sympathetic chain; quantitative studies on white rami communicantes

Appenzeller

Ogin

1973

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY Myelinated fibres in the human sympathetic paravertebral chain were examined histologically and in single teased fibre preparations in various age groups in subjects dying from disorders not affecting primarily the autonomic nervous system. An increase in fibre density predominantly due to an increase in the number of small fibres was found in older subjects. A correlation between internodal length and fibre diameter was found but the internodes of sympathetic myelinated fibres are shorter for any given diameter than those found on fibres of comparable size in the sural nerve. A reduction in internodal lengths with advancing years was demonstrated. These observations are interpreted to show that Wallerian degeneration and segmental demyelination occur with increasing frequency in old age and that regeneration does not keep pace with successive degenerative events. The deterioration in function of the autonomic nervous system with advancing years may be attributed in part to the changes found in myelinated fibres in the paravertebral sympathetic chain.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 96%

Myelinated fibres in the human paravertebral sympathetic chain; quantitative studies on white rami communicantes

Appenzeller

Ogin

1973

Journal of Neurology, Neurosurgery & Psychiatry

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“…Schwann cell abnormalities were stressed by Thomas and Lascelles (1965 and 66) in a study of human diabetes [19,20]. In that study, however, it was also mentioned that three of the five patients, in whom examination of isolated nerve fibres was performed, had a number of fibres with long internodes, but inappropriately small calibres.…”

Section: Discussionmentioning

confidence: 97%

“…After several years of diabetes the degenerative changes in the peripheral nerves in humans are of mixed pathology [18,19,20,21], although segmental demyelination is usually emphasized.…”

Section: Discussionmentioning

confidence: 99%

Axonal dwindling in early experimental diabetes. II. A study of isolated nerve fibres

Jakobsen

1976

Diabetologia

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Summary. In a morphometric study of isolated fibres of the common peroneal nerve in short-term diabetic rats reduced fibre calibre was observed. No segmental demyelination or remyelination was found, but the nodes of Ranvier were slightly widened and paranodal bulbi were swollen relative to fibre calibre. It is suggested that axonal dwindling is the primary event in experimental diabetes. The reduction of the myelin sheath may be a consequence of the abnormal nerve cell offshoot. The results obtained suggest that streptozotocin diabetes in the rat is a useful model for the elucidation of diabetic neuropathy.

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“…In diabetic neuropathy, a decrease in nerve conduction velocity (NCV), segmental demyelination in nerve fibers, and an impairment of Schwann cells are observed in peripheral nerves (2). In animal experiments, thickening and degeneration of the myelin sheath are observed in both alloxan and streptozotocin (STZ) diabetic rats, and this demyelination may result in the reduction of NCV observed in diabetic rats (3)(4)(5).…”

mentioning

confidence: 99%

Effects of vitamin B mixture on neuropathy in streptozotocin-induced diabetic rats.

Sakitama

Saito

et al. 1989

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Vitamin B mixture, especially a mixture of B1, B6, and B12, provides beneficial effects when used for the clinical treatment of various types of neuropathy including that in diabetes (1). In diabetic neuropathy, a decrease in nerve conduction velocity (NCV), segmental demyelination in nerve fibers, and an impairment of Schwann cells are observed in peripheral nerves (2). In animal experiments, thickening and degeneration of the myelin sheath are observed in both alloxan and streptozotocin (STZ) diabetic rats, and this demyelination may result in the reduction of NCV observed in diabetic rats (3-5). NCV is used as a major diagnostic and therapeutic index for assessing the function of peripheral nerves in diabetic neuropathy. Iwata et al. (6) and Fukuda et al. (7) reported an ameliorating effect of vitamin B mixture (B1, B6, and B12) on the decrease in NCV in alloxan diabetic rats. However, there is little information concerning the effects of vitamin B mixture on STZ-induced diabetic neuropathy, which is considered the preferable model for studying severe diabetic peripheral neuropathy (8). Thus, we investigated the effects of daily administration of 3B (a mixture of thiamine disulfide, pyridoxal hydrochloride and aquocobalamin) on STZ-induced diabetic neuropathy using NCV as the index. In accordance with a previous report (9) which demonstrated the favorable effects of a high dose of 3B on neuropathy induced by acrylamide, we also adopted a relatively high dose of 3B.The experiments were carried out on 3 groups of male Sprague-Dawley rats (9 weeks old, n=14-19). A standard laboratory chow (CRF-1, Charles River) and tap water were always available. Daily intake of vitamin B1, B6, and B12 from the diet was approximately 1.5, 0.5, and 0.0075mg per rat, respectively. Two groups were made diabetic by intraveneous injection of 45mg/kg STZ (Sigma) dissolved in citrate buffer (pH 4.1) immediately before use. The third group received the citrate 95

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Schwann-Cell Abnormalities in Diabetic Neuropathy

Cited by 127 publications

References 7 publications

Myelinated fibres in the human paravertebral sympathetic chain; quantitative studies on white rami communicantes

Myelinated fibres in the human paravertebral sympathetic chain; quantitative studies on white rami communicantes

Axonal dwindling in early experimental diabetes. II. A study of isolated nerve fibres

Effects of vitamin B mixture on neuropathy in streptozotocin-induced diabetic rats.

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