Schwund markhaltiger Nervenfasern in der Netzhaut nach Embolie der Art. centralis retinae

Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis

“…Within two months after the retinal vascular event, the RNFL loss became visible as degeneration of bundles of myelinated retinal axons (Figure 2 A), progressing over the following two months (Figure 2 B) and leading to complete optic atrophy and 6 loss of myelinated axons observed on fundus exam within one year ( Figure C). 40 There is good post-mortem evidence for RNFL thinning in MS. 41 RNFL in MSON In multiple sclerosis, following optic neuritis (MSON), the degree of RNFL loss in thickness is in the range of 5-40 µm, averaging at 10-20 µm. 6 The finding was significant for all studies using time domain OCT (TD-OCT) technology based on the Stratus OCT (Zeiss, software version 3.0 & 4.0) that we identified in a systematic literature review.…”

“…A later case of sectoral RNFL loss in which sequential in vivo images permitted to evoke the concept of ascending axonal degeneration (now known as Wallerian degeneration) was facilitated by the rare presence of myelinated fibres in the retina. 40 Bachmann describes a 28 year old man in whom sudden loss of vision in the right eye on the 22nd of January 1920 was due to a central retinal artery occlusion. Within two months after the retinal vascular event, the RNFL loss became visible as degeneration of bundles of myelinated retinal axons (Figure 2 A), progressing over the following two months (Figure 2 B) and leading to complete optic atrophy and 6 loss of myelinated axons observed on fundus exam within one year ( Figure C).…”

Myelinated retinal nerve fibres loss in Leber's hereditary optic neuropathy

“…It usually remains unchanged, although MNRF may disappear after damage of the retinal ganglion cells. Several causes have been reported, namely, retinal artery occlusion, diabetic retinopathy (Gentile et al 2002), radiotherapy for choroidal melanoma (Mashayekhi et al 2003), chronic glaucoma (Lopez Sanchez et al 2002), optic neuritis (Sharpe & Sanders 1975), and compression of the anterior optic pathway from the inner layer (central or branch retinal artery occlusion) (Bachmann 1922; Teich 1987), to the lateral geniculate body (Gentile et al 2002).…”