Scientific Opinion on the substantiation of health claims related to soy isoflavones and maintenance of bone mineral density (ID 1655) and reduction of vasomotor symptoms associated with menopause (ID 1654, 1704, 2140, 3093, 3154, 3590) (further assessmen

Products, Efsa Panel on Dietetic

doi:10.2903/j.efsa.2012.2847

Cited by 23 publications

(4 citation statements)

References 80 publications

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“…The European Food Safety Authority has evaluated the effects of isoflavones on the risk of cardiovascular disease, with a focus on the effects on lipid profile. (23) Several previous studies have investigated the important clinical effects of isoflavones on the decreases in total cholesterol, LDL cholesterol, and TAG levels and on the increase in HDL cholesterol levels. These studies that were reported in the last ten years failed to demonstrate that isoflavones exert significant clinical effects, and failed to find the active isoflavone compounds that play a role in lipid metabolism.…”

Section: Discussionmentioning

confidence: 99%

High dietary daidzein intake lowers cholesterol levels among post-menopausal women

Herwana

Pusparini

Graciela³

2020

Universa Medicina

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Background Menopause is associated with changes in metabolic profile. Although hormone replacement therapy (HRT) has been shown to have beneficial effects on lipid metabolism, its adverse effects have indicated a need for alternative estrogen-based treatments. Several investigations have evaluated the effects of isoflavones on serum lipid levels in postmenopausal women, but the results were ambiguous. The objective of this study was to determine the relationship of dietary daidzein, genistein, and glycitein levels with lipid profile in postmenopausal women. Methods A cross-sectional study was conducted involving 186 post-menopausal women. A food recall questionnaire was used to measure dietary genistein, daidzein, and glycitein levels. Serum total cholesterol (TC), low density lipoprotein (LDL) cholesterol, high density lipoprotein (HDL) cholesterol, and triacylglycerol (TAG) were measured using the enzymatic colorimetric method. Simple and multivariate linear regression were used to analyze the data. Results Genistein intake was significantly associated with TC (b=145.48, p=0.023) and HDL cholesterol levels (b=48.80, p=0.032). Daidzein intake was significantly associated with TC (b=-204.60, p=0.003), LDL cholesterol (b=-160.81, p=0.014) and HDL cholesterol levels (b=-67.118, p=0.032). Glycitein was not significantly associated with TC (b=232.78;p=0.133), HDL (b=43.59;p=0.428), and LDL (b=235.84;p=0.116). Dietary daidzein had a more lowering effect on TC (Beta=-2.80) and HDL cholesterol (Beta=-2.67) than had genistein on TC (Beta=2.66) and HDL cholesterol (Beta=2.03). Conclusions High dietary daidzein level has a significant lowering effect on TC, LDL cholesterol and HDL cholesterol in post-menopausal women. Our study supports the advice given to the public to increase soy isoflavone intake in post-menopausal women.

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Section: Discussionmentioning

confidence: 99%

High dietary daidzein intake lowers cholesterol levels among post-menopausal women

Herwana

Pusparini

Graciela³

2020

Universa Medicina

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“…Epidemiological studies suggest high intakes of isoflavones to be associated with fewer and less intense menopause symptoms, and a reduced incidence of hormone-dependent and aging-associated diseases such as osteoporosis, cardiovascular diseases and cancer [1]. Although there is a growing body of scientific evidence showing beneficial effects in counteracting symptoms such as hot flushes and vasomotor reactions in menopausal women [2], the European Food Safety Authority (EFSA) has recently refuted health claims about the role of isoflavones in body functions [3]. This may be so because the functionality of isoflavones depends on their bioavailability and their conversion into (more) active metabolites within the intestinal tract.…”

Section: Introductionmentioning

confidence: 99%

Bacterial communities and metabolic activity of faecal cultures from equol producer and non-producer menopausal women under treatment with soy isoflavones

et al. 2017

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BackgroundIsoflavones are polyphenols with estrogenic activity found mainly in soy and soy-derived products that need to be metabolised in the intestine by the gut bacteria to be fully active. There is little knowledge about isoflavone bioconversion and equol production in the human intestine. In this work, we developed an in vitro anaerobic culture model based on faecal slurries to assess the impact of isoflavone supplementation on the overall intestinal bacterial composition changes and associated metabolic transformations.ResultsIn the faecal anaerobic batch cultures of this study bioconversion of isoflavones into equol was possible, suggesting the presence of viable equol-producing bacterial taxa within the faeces of menopausal women with an equol producer phenotype. The application of high-throughput DNA sequencing of 16S rRNA gene amplicons revealed the composition of the faecal cultures to be modified by the addition of isoflavones, with enrichment of some bacterial gut members associated with the metabolism of phenolics and/or equol production, such as Collinsella, Faecalibacterium and members of the Clostridium clusters IV and XIVa. In addition, the concentration of short-chain fatty acids (SCFAs) detected in the isoflavone-containing faecal cultures was higher in those inoculated with faecal slurries from equol-producing women.ConclusionsThis study constitutes the first step in the development of a faecal culturing system with isoflavones that would further allow the selection and isolation of intestinal bacterial types able to metabolize these compounds and produce equol in vitro. Although limited by the low number of faecal cultures analysed and the inter-individual bacterial diversity, the in vitro results obtained in this work tend to indicate that soy isoflavones might provide an alternative energy source for the increase of equol-producing taxa and enhancement of SCFAs production. SCFAs and equol are both considered pivotal bacterial metabolites in the triggering of intestinal health-related beneficial effects.Electronic supplementary materialThe online version of this article (doi:10.1186/s12866-017-1001-y) contains supplementary material, which is available to authorized users.

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“…Sur 1 colonne près de son appel TEG1 Bien que de nombreuses études soient publiées sur les isoflavones de soja, leurs méthodologies et résultats ne permettent pas d'affirmer qu'ils permettent de diminuer les bouffées de chaleur [26][27][28]. Ils pourraient empêcher l'ostéoporose mais se limiteraient à maintenir la densité minérale et non à prévenir les risques de fractures.…”

Section: Encadré 2 Définition Des Phyto-estrogènesunclassified

Phytothérapie et troubles urogénitaux, sélectionner des produits efficaces et sûrs

Derbré

2019

Actualités Pharmaceutiques

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Scientific Opinion on the substantiation of health claims related to soy isoflavones and maintenance of bone mineral density (ID 1655) and reduction of vasomotor symptoms associated with menopause (ID 1654, 1704, 2140, 3093, 3154, 3590) (further assessmen

Cited by 23 publications

References 80 publications

High dietary daidzein intake lowers cholesterol levels among post-menopausal women

High dietary daidzein intake lowers cholesterol levels among post-menopausal women

Bacterial communities and metabolic activity of faecal cultures from equol producer and non-producer menopausal women under treatment with soy isoflavones

Phytothérapie et troubles urogénitaux, sélectionner des produits efficaces et sûrs

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