Scleredema Diabeticorum Partially Treated with Low-Dose Methotrexate: a Report of Five Cases

Doğramacı, Asena Çiğdem; İnan, Mehmet Uğur; Atık, Esin; Gökçe, Cumali

doi:10.5152/balkanmedj.2011.027

Cited by 9 publications

(5 citation statements)

References 12 publications

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“…Other treatments classically used are immunomodulators like corticosteroids, cyclosporine and methotrexate, despite inconsistent results. 2 , 12 , 13 Due to concerns over adverse effects, these options should be reserved for patients with persistent, debilitating disease in whom phototherapy failed or for patients with scleredema-associated multiple myeloma. 9 …”

Section: Discussionmentioning

confidence: 99%

Scleredema diabeticorum

Pereira¹,

Pinheiro²,

Lencastre³

et al. 2022

Dermatol Reports

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Scleredema of Buschke is a rare connective tissue disease with a poorly understood pathogenesis. Three types of scleredema have been distinguished according to its association with preceding or underlying conditions. Type 1 is usually secondary to a febrile infection, type 2 is mostly associated with paraproteinemia and type 3, usually named scleredema diabeticorum, has a strict association with Diabetes mellitus. A diffuse, non-pitting swelling and induration of the skin define this disease. The skin histology is characterized by a normal or slightly thinned epidermis, and the dermis containing a decreased number of elastic fibers and thick large swollen collagen bundles separated by mucopolysaccharide deposits in the deep reticular dermis. In this report we present a 58-year-old man with scleredema diabeticorum controlled with a topical steroid cream and an optimization of glycemic control. We reviewed clinical, histopathological characteristics and the various possible treatments.

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Section: Discussionmentioning

confidence: 99%

Scleredema diabeticorum

Pereira¹,

Pinheiro²,

Lencastre³

et al. 2022

Dermatol Reports

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“…Histologically, the skin specimen shows thickening of the dermis with swollen collagen fibers in bundles and deposits of mucin, which can be stained by alcian blue dye. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

“…But the vast majority of reported patients have undergone systemic therapy with systemic steroids, methotrexate, cyclosporine, IVIg, and colchicine. [ 1 2 3 4 5 6 7 8 9 ] Physical therapy is recommended to increase range of motion. [ 10 ]…”

Section: Discussionmentioning

confidence: 99%

Scleredema diabeticorum – A case report

Kyriakou

Zagalioti

Lazaridou

et al. 2021

Journal of Family Medicine and Primary Care

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Scleredema diabeticorum is an uncommon skin disorder which is characterized by stiffness and hardening of the subcutaneous tissues located on the upper back and posterior neck. Patients with this skin disease typically experience pain and stiffness on the neck. Scleredema associated with diabetes mellitus may often go unrecognized. We report a case of a 55-year-old female patient with diabetes mellitus type 1, who presented with skin tightness on her upper back and decreased range of motion. Scleredema diabeticorum is rare and its treatment is difficult and tricky, as no specific regimen has been instituted to treat this skin disease.

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“…Aun no se ha establecido un tratamiento específico y efectivo para el escleredema diabeticorum, pero se recomienda la pérdida de peso y un estricto control de la diabetes, que si bien no resuelve el problema sí puede ayudar a detener o mejorar parcialmente la progresión de la lesión cutánea (12). Entre los diferentes tratamientos propuestos, pero con resultados inconstantes encontramos inmunosupresores (como la ciclosporina y metotrexate) en el escleredema asociado a mieloma; fotoquimioterapia con psoraleno y radiación ultravioleta A (PUVA) (10,11).…”

Section: Discussionunclassified

Escleredema Diabeticorum

et al. 2021

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Dentro de los trastornos cutáneos asociados a la diabetes mellitus, se describe el escleredema diabeticorum el cual se caracteriza por un engrosamiento de las capas profundas de la dermis con depósito excesivo de mucina y colágeno, que produce clínicamente endurecimiento de la piel, principalmente en la mitad superior del cuerpo. Se describe un caso clínico correspondiente a un hombre adulto diabético que consulto por la aparición de una lesión indurada en la región cervical con posterior diagnostico histopatológico de escleroderma diabeticorum. El interés radica en la baja prevalencia de la condición y su asociación al pobre control metabólico de la diabetes.

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Scleredema Diabeticorum Partially Treated with Low-Dose Methotrexate: a Report of Five Cases

Cited by 9 publications

References 12 publications

Scleredema diabeticorum

Scleredema diabeticorum

Scleredema diabeticorum – A case report

Escleredema Diabeticorum

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