Sclerosing hemangioma (histiocytoma, xanthoma) of the lung

Liebow, Averill A.; Hubbell, David S.

doi:10.1002/1097-0142(195601/02)9:1<53::aid-cncr2820090104>3.0.co;2-u

Cited by 361 publications

(187 citation statements)

References 11 publications

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“…clerosing hemangioma (SH), also know as pneumocytoma, is an uncommon benign neoplasm of the lung first described by Liebow and Hubbell 16 in 1956 and included in the ''miscellaneous tumor'' category in the most recent World Health Organization (WHO) classification of lung tumors. 33 SH has 4 basic histologic patterns (solid, hemorrhagic, papillary, and fibrotic) often mixed with each other, and 2 cell populations consisting of surface cuboidal cells lining the papillae and polygonal stromal cells growing in the interstitium.…”

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Microsatellite and EGFR, HER2 and K-RAS Analyses in Sclerosing Hemangioma of the Lung

Sartori

Bettelli

Schirosi

et al. 2007

American Journal of Surgical Pathology

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Sclerosing hemangioma (SH) is an uncommon pulmonary tumor thought to derive from primitive respiratory epithelium consisting of 2 cell populations (cuboidal surface and polygonal stromal cells) and sharing some clinical characteristics (frequent occurrence in nonsmoking women of Asian ethnicity) with bronchioloalveolar carcinoma with which it has been suggested a possible common origin. We investigated 11 cases of SH by immunohistochemistry, fluorescence in situ hybridization, and polymerase chain reaction-based microsatellite and mutational analyses with particular emphasis on possible alterations of microsatellite loci located at tumor suppressor genes (FHIT, p16, Rb, and p53) involved in lung adenocarcinoma genesis and EGFR, HER2, and K-RAS genes. Although EGFR expression was observed in all tested cases, none showed HER2 immunostaining. Fluorescence in situ hybridization and mutational analysis of EGFR and HER2 and also K-RAS sequencing did not reveal molecular alterations, whereas allelic losses at p16 and Rb loci (4 and 2 out of 9 tested cases, respectively) with an identical microsatellite allelic loss pattern in both cuboidal and polygonal cells were observed. The finding of microsatellite alterations in chromosomal regions related to genes deeply involved in early stage lung adenocarcinoma could suggest a possible link between SH and bronchioloalveolar carcinoma, but tumor pathway promoted by EGFR, HER2, and K-RAS does not represent a common molecular mechanism of tumorigenesis. Microsatellite alterations identified in cuboidal and polygonal cells further confirm the clonal and neoplastic nature of both components of SH. SH has 4 basic histologic patterns (solid, hemorrhagic, papillary, and fibrotic) often mixed with each other, and 2 cell populations consisting of surface cuboidal cells lining the papillae and polygonal stromal cells growing in the interstitium. 33 The tumor has been the subject of several controversies about its histogenesis and, although it is now accepted that the polygonal cells are neoplastic and take origin from primitive respiratory epithelium, some controversies remain about the nature of the surface cuboidal cells (entrapped alveoli? a complete differentiation of the polygonal ones?) and the relationship between the 2 cell types. 6,10,14,27,34,37,39,41 To date, no systemic metastases have been reported for this tumor, while it can show cellular atypia, foci of vascular invasion, and metastatic deposits into the regional lymph nodes. 20,32,38 However, none of these features seems to affect the good prognosis of patients with SH. 20It is surprising to note that both SH and nonmucinous type bronchioloalveolar carcinoma (nm-BAC) share several clinical characteristics, given that both neoplasms most commonly occur in nonsmoking, middle-aged women of East Asia ethnicity.33 Several works recently demonstrated that patients with nm-BAC or pulmonary adenocarcinoma with prominent BAC features are also frequently characterized by somatic and mutually exclusive mutations involvi...

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confidence: 99%

Microsatellite and EGFR, HER2 and K-RAS Analyses in Sclerosing Hemangioma of the Lung

Sartori

Bettelli

Schirosi

et al. 2007

American Journal of Surgical Pathology

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“…5) According to the 1999 histological classification of lung tumors by the World Health Organization, sclerosing hemangioma is defined as a miscellaneous tumor. Although never considered a vascular lesion, it was named such on account of the frequent hemorrhage and hemosiderin deposition within the tumor.…”

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Microscopic Sclerosing Hemangioma Diagnosed by Histopathological Examination after Lung Cancer Surgery

Goto

Maeshima

Kato

2011

ATCS

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A 44-year-old woman underwent surgery for lung cancer. Although preoperative computed tomography did not reveal a tiny nodule, pathological examination of the background lung showed that type II pneumocyte-like tumor cells grew papillary in an area of approximately 2.3 × 1.2 mm. This lesion exhibited hemorrhage, hemosiderosis, calcification, and varying degrees of fibrosis, leading to the diagnosis of sclerosing hemangioma. This is the first reported case of microscopic sclerosing hemangioma undetectable by chest computed tomography.

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“…They defi ned pulmonary fi brosing haemangioma as a marked vascular proliferation with a tendency to fi brosis, and associated with papillary vegetation, extensive histiocytic infi ltration and haemorrhage at various stages of organization 1 . This tumor was originally thought to be a lesion derived from vascular structures due to its rich content of blood vessels.…”

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Sclerosing haemangioma of the lung: A case report

Thapa

Lakhey

Shrestha³

2012

J. Kathmandu Med. Coll.

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Sclerosing haemangioma is a rare neoplasm of the lung which behaves in a clinically benign fashion. Herein, a case of sclerosing haemangioma of the lung in a 52 years old woman is reported. She presented with symptoms of cough and chest pain. Chest X -ray and CT scan showed a well -defi ned lesion in lower lobe of left lung. Bronchoscopic biopsy fi ndings were suggestive of a carcinoid tumor. Later the tumor was removed by lobectomy. The distinctive constellation of histologic fi ndings revealed it to be a sclerosing haemangioma.

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Sclerosing hemangioma (histiocytoma, xanthoma) of the lung

Cited by 361 publications

References 11 publications

Microsatellite and EGFR, HER2 and K-RAS Analyses in Sclerosing Hemangioma of the Lung

Microsatellite and EGFR, HER2 and K-RAS Analyses in Sclerosing Hemangioma of the Lung

Microscopic Sclerosing Hemangioma Diagnosed by Histopathological Examination after Lung Cancer Surgery

Sclerosing haemangioma of the lung: A case report

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