Sclerosing Sweat Duct Carcinoma in a 6‐Year‐Old African American Child

Nelson, Peter S.; Bourgeois, Kristal M.; Nicotri, Thomas; Chiu, Ernest S.; Poole, Jeffrey C.

doi:10.1111/j.1525-1470.2007.00579.x

Cited by 17 publications

(15 citation statements)

References 33 publications

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“…The aggressive and locally invasive nature of the disease results in high recurrence rates, ranging from 15-60% depending on the treatment modality, with lower rates of recurrence observed following Mohs micrographic surgery (21)(22)(23)(24). However, such data may be an overestimate, with misdiagnosis often occurring at the time of excision, and positive margins can occasionally be misread.…”

Section: Discussionmentioning

confidence: 89%

Microcystic adnexal carcinoma in a non-Caucasian patient: A case report and review of the literature

et al. 2016

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Abstract. Microcystic adnexal carcinoma (MAC) is extremely rare among Asians, with the majority of cases presenting in Caucasian individuals. The current study describes the case of a 38-year-old Chinese woman who presented with a 10 year history of a mass in the upper lip. A biopsy resulted in a diagnosis of MAC. The patient underwent complete surgical resection and the tumor was successfully excised. During 6 months of follow-up, there was no evidence of recurrence. To the best of our knowledge, the present case is the first Chinese case to be reported in the English literature, and is presented with the aim of increasing the awareness and aiding in the management of MAC in non-Caucasian populations. IntroductionMicrocystic adnexal carcinoma (MAC) was originally defined in 1982 (1), and is now also termed sclerosing sweat duct carcinoma (2). MAC is a rare, slow-growing, locally aggressive tumor of the eccrine sweat glands, and is characterized by pilar and eccrine differentiation (3). Sweat gland malignancies, combining all types, are particularly rare, accounting for 0.005% of all malignant epithelial neoplasms (4), with a total of ~350 cases currently described in the English literature. It has been reported that the preferential location for the development of this neoplasm is the head and neck region (5).When referring to the English literature, it is evident that MAC primarily affects the Caucasian population, with only two cases occurring in non-Caucasian patients (6,7). Fang et al (8) described two cases involving Chinese individuals in the Chinese literature; however, to the best of our knowledge, there are no cases of Chinese patients with MAC currently reported in the English literature. The present study reviewed all patients that were referred to the Hainan Province People's Hospital (Haikou, China) between January 1994 and January 2014, and identified only one patient with a MAC diagnosis. This case is described herein along with a review of the relevant literature. Case reportA 38-year-old woman was referred to the Department of Oral and Maxillofacial Surgery at the Hainan Province People's Hospital with a mass on the left upper-lip that had been present for >10 years (Fig. 1). During physical examination, it was noted that the tumor was positioned in the left-upper lip and subnasal region. The lesion was a firm, solitary mass, and measured 2x1 cm in size. No submandibular or cervical lymph nodes were palpable during the physical examination. Abdominal ultrasonography and computed tomography (CT; Brilliance iCT; Philips Medical Systems, Amsterdam, Holland) of the head, neck and thorax demonstrated no evidence of systemic or local metastasis. As presented in Fig. 2, the head and neck CT scans revealed the lesion located in the subcutaneous tissue of the left-upper lip, with a wide base inseparable from overlying skin.An incisional biopsy was performed with the patient under local anesthesia. The diagnosis of the specimen was confirmed as carcinoma. The patient underwent complete surgical resection...

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Section: Discussionmentioning

confidence: 89%

Microcystic adnexal carcinoma in a non-Caucasian patient: A case report and review of the literature

et al. 2016

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“…Examination demonstrated a 1-cm verrucous plaque affixed to a firm, subcutaneous nodule with peripheral telangiectasias (Figure 1). 4 While it is considered to have limited metastatic potential, MAC can cause significant morbidity owing to local invasion. Histologic analysis demonstrated an infiltrative, dermal tumor of basaloid cystic and tubular structures in a dense, hyaline stroma, consistent with MAC ( Figure 2).…”

Section: Congenital Microcystic Adnexal Carcinomamentioning

confidence: 99%

“…The tumor extended to the inked margins, but perineural invasion was not seen. 4 Excision with confirmation of negative margins is the accepted treatment for MAC. Magnetic resonance imaging (MRI) showed no evidence of extracutaneous metastasis.…”

Section: Congenital Microcystic Adnexal Carcinomamentioning

confidence: 99%

Congenital Microcystic Adnexal Carcinoma

Fu¹,

Clark²,

Lorenz³

et al. 2011

Arch Dermatol

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“…Biopsy findings include cords and nests of uniform keratinocytes, keratin-containing cysts, and foci of ductal differentiation in a sclerotic desmoplastic stroma (7). The tumor cells express a distinctive pattern of staining for epithelial membrane antigen (24), carcinoembryonic antigen (24,25), cytokeratin AE1/AE3 (23,24), and focal expression of Bcl-2 that differentiate them from sBCCs and dTEs (22,26). …”

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confidence: 99%

“…Radiation can be considered as an adjunctive therapy; however, this tumor has been shown to be fairly radioresistant (4,14). Reported recurrence rates range from 40% to 60% depending on the treatment modality, with lower rates after MMS (24,27,28); however, these statistics may be an overestimate as there is often misdiagnosis at the time of excision, and positive margins can sometimes be misread.…”

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Unusual Presentation of Primary Orbital Microcystic Adnexal Carcinoma

Wu-Chen

Weng

Rajan

et al. 2011

Journal of Neuro-Ophthalmology

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Microcystic adnexal carcinoma (MAC) is a rare and locally aggressive malignancy that occurs on the face, can invade deep tissue, and can rarely invade the orbit via perineural spread. It has been reported most often in the form of a cutaneous lesion. Although there have been 3 prior case reports of an orbital presentation of MAC, all have been from undiagnosed cutaneous or subcutaneous lesions. We report a rare case of a primary orbital MAC in a 39-year-old healthy woman who presented with progressive diplopia and enophthalmos without evidence of any cutaneous or subcutaneous lesions.

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Sclerosing Sweat Duct Carcinoma in a 6‐Year‐Old African American Child

Cited by 17 publications

References 33 publications

Microcystic adnexal carcinoma in a non-Caucasian patient: A case report and review of the literature

Microcystic adnexal carcinoma in a non-Caucasian patient: A case report and review of the literature

Congenital Microcystic Adnexal Carcinoma

Unusual Presentation of Primary Orbital Microcystic Adnexal Carcinoma

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