Scores of peripheral neuropathic pain predicting long-term mortality in patients with type 2 diabetes: A retrospective cohort study

Abstract

ObjectivesDiabetic peripheral neuropathic pain (DPNP) is a prevalent chronic complication in patients with diabetes. Using a questionnaire is helpful for DPNP screening in outpatients. In this retrospective cohort, we aimed to examine whether DPNP diagnosed based on scoring questionnaires could predict long-term mortality in outpatients with type 2 diabetes.MethodsWe enrolled 2318 patients who had joined the diabetes pay-for-performance program and completed the annual assessments, including both the identification pain questionnaire (ID pain) and Douleur Neuropathique en 4 questionnaire (DN4), between January 2013 and October 2013. Information on registered deaths was collected up to August 2019.ResultsThere was high consistency in the scores between the ID pain and DN4 (r = 0.935, P < 0.001). During the median follow-up of 6.2 years (interquartile range: 5.9−6.4 years), 312 patients deceased. Patients with an ID pain score of ≥ 2 had a higher mortality risk than those with a score of < 2 (hazard ratio [HR] = 1.394, 95%CI: 1.090−1.782), and patients with a DN4 score of ≥ 4 had a higher mortality risk than those with a score of < 4 (HR = 1.668, 95% confidence interval [CI]: 1.211−2.297). Patients consistently diagnosed with DPNP by the ID pain and DN4 had a significantly higher mortality risk (HR = 1.713, 95% CI: 1.223−2.398, P = 0.002), but not those discrepantly diagnosed with DPNP (P = 0.107), as compared with those without DPNP.ConclusionsBoth the ID pain and DN4 for DPNP screening were predictive of long-term mortality in patients with type 2 diabetes. However, a discrepancy in the diagnosis of DPNP weakened the power of mortality prediction.

Factors correlated with neuropathic pain among industrial workers in Vietnam: a multi-site cross-sectional study

“…Within our cohort of Vietnamese factory workers, the prevalence of neuropathic pain was estimated to be 1%, which is low compared to estimates of global prevalence ( 10 ). Specifically, some previous studies reported that the prevalence of neuropathic pain in Canada was 17.9% ( 23 ), Brazil was 10% ( 24 ), French was 6.9% ( 25 ), the UK was 8% ( 26 ), Australia was 3.3% ( 11 , 23 , 27 ), Brazil ( 24 ), was 10%, Thailand was 24.0% ( 28 ), and Taiwan was 7.9% ( 29 ). This figure may have been underestimated due to various external factors.…”

Tip 2 Diabetes Mellitus Hastalarının İn Vivo Korneal Konfokal Mikroskopi ile Değerlendirilmesi

“…Diyabetik periferik nöropati, diyabetin en sık görülen uzun vadeli komplikasyonlarından biridir 2 ve tip 2 DM tanısı alan hastalarda diyabetle ilişkili mortalite için bağımsız bir belirteçtir. 3 İntraepidermal sinir liflerinin (IENF) ölçümü, küçük lif nöropatisinin mevcut altın standart ölçüsüdür. 13 Ancak bu, cilt biyopsisi gerektiren minimal invaziv bir prosedürdür.…”

“…1 Diyabetik periferik nöropati (DPN), DM'li hastaların en az %50'sini etkileyen, diyabetin en sık görülen uzun vadeli komplikasyonlarından biridir ve tip 2 diyabet tanısı alan hastalarda diyabetle ilişkili mortalite için bağımsız bir belirteçtir. 2,3 Başlangıçta küçük miyelinsiz C liflerini etkileyen duyusal kayıp ve ağrı, ardından büyük, miyelinli sinir lifi tutulumu ile karakterizedir. Diyabetik nöropati esas olarak periferik sinir duyarlılığının kaybı ile ilişkilidir.…”

Динаміка Ознак Невропатичного Болю При Застосуванні Фізіотерапевтичних Процедур У Комплексному Лікуванні Хворих На Діабетичну Полінейропатію

“…Він складається з двох блоків запитань: перший блок складається із 7 запитань до хворого, за допомогою яких виявляють сенсорні симптоми, а саме спонтанний біль, до якого відносяться такі симптоми, як: відчуття печії, болюче відчуття холоду, відчуття, як від ударів струмом, та наявність парестезії і дизестезії: відчуття повзання мурашок, поколювання, оніміння, свербіж; до другого блоку опитувальника входять 3 висновки лікаря на підставі клінічного огляду, що дає можливість лікарю виявити алодинію та негативні сенсорні симптоми. Якщо позитивних відповідей понад 4 із 10 пунктів, то це свідчить про наявність у пацієнта невропатичного болю [8,12].…”