<scp>DNA</scp>
            Computing: Origination, Motivation, and Goals – Illustrated Introduction

Katz, Evgeny

doi:10.1002/9783527825424.ch1

Cited by 5 publications

(4 citation statements)

References 93 publications

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“…However, our system, which has a logic-based module system can be extended for flexibility by a DNA algorithm for the complex logic reactions. The DNA computing chip could be further extended to achieve high-performance DNA computing based on CRNs for solving the SAT problem and neural networks ,, and with enzymes such as those employed in fast DNA computing − and virus detection. , Furthermore, when the DNA MPU chip meets with the DNA and RNA computing system, , a variety of proteins could be programmably produced by human machine interface operation such as a PC or smartphone interface, similar to current electronic-based computer systems.…”

Section: Discussionmentioning

confidence: 99%

Programmable DNA-Based Boolean Logic Microfluidic Processing Unit

Lee

Lim

et al. 2021

ACS Nano

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As molecular computing materials, information-encoded deoxyribonucleic acid (DNA) strands provide a logical computing process by cascaded and parallel chain reactions. However, the reactions in DNA-based combinational logic computing are mostly achieved through a manual process by adding desired DNA molecules in a single microtube or a substrate. For DNA-based Boolean logic, using microfluidic chips can afford automated operation, programmable control, and seamless combinational logic operation, similar to electronic microprocessors. In this paper, we present a programmable DNA-based microfluidic processing unit (MPU) chip that can be controlled via a personal computer for performing DNA calculations. To fabricate this DNA-based MPU, polydimethylsiloxane was cast using double-sided molding techniques for alignment between the microfluidics and valve switch. For a uniform surface, molds fabricated using a three-dimensional printer were spin-coated by a polymer. For programming control, the valve switch arms were operated by servo motors. In the MPU controlled via a personal computer or smartphone application, the molecules with two input DNAs and a logic template DNA were reacted for the basic AND and OR operations. Furthermore, the DNA molecules reacted in a cascading manner for combinational AND and OR operations. Finally, we demonstrated a 2-to-1 multiplexer and the XOR operation with a three-step cascade reaction using the simple DNA-based MPU, which can perform Boolean logic operations (AND, OR, and NOT). Through logic combination, this DNA-based Boolean logic MPU, which can be operated using programming language, is expected to facilitate the development of complex functional circuits such as arithmetic logical units and neuromorphic circuits.

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Section: Discussionmentioning

confidence: 99%

Programmable DNA-Based Boolean Logic Microfluidic Processing Unit

Lee

Lim

et al. 2021

ACS Nano

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“…There are several main directions for the design of DNA logic gates: (1) enzyme-free gates that follow a simple model of strand displacement but suffer from a slow processing speed and are incapable of multiple rounds of operation, 19 such as (a) seesaw gates (SDR) 20 and (b) structural switches (SSR) 21–23 and (2) enzymatically active complexes based on Dz or ribozyme (Rz) catalytic activity. 24 RNA-cleaving Dzs 25 are attractive candidates for the development of DNA logic gates that can solve the aforementioned issues due to their (1) catalytic activity, (2) ability of multiple turnover reactions which lead to significant signal amplification, and (3) flexible sequence adaptation to interact with virtually any input and/or target nucleic acid sequence. 14,18…”

Section: Introductionmentioning

confidence: 99%

Towards the development of a DNA automaton: modular RNA-cleaving deoxyribozyme logic gates regulated by miRNAs

Smirnov,

Drozd,

Patra

et al. 2024

Analyst

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“…DNA hybrid nanoarchitectures have been engaged in programming the molecular organization of DNA as a multimode biocomputing tool. 1–5 Among the various nanoarchitectures, nanoclusters (NCs) have been a promising candidate due to their unique self-assembly properties and programmability, such as fluorescent organic NCs, protein-based NCs, and single-stranded DNA-templated metal NCs. 6–10 They have attracted great attention due to their intriguing properties, such as low toxicity, excellent water solubility, rapid synthesis, significant stokes shifts, and good biocompatibility.…”

Section: Introductionmentioning

confidence: 99%