Murraya paniculata(L.) (Orange Jasmine): Potential Nutraceuticals with Ameliorative Effect in Alloxan‐Induced Diabetic Rats

Abstract

Orange jasmine, Murraya paniculata (Rutaceae), is a plant from India widely used in folk medicine as antinociceptive, antiinflammatory, and antioxidant. Although oral hypoglycemic agents and insulin are the mainstays of treatment of diabetes mellitus (DM), there is a significant demand for new natural products to reduce the development of diabetic complications. Alloxan-induced diabetic rats were treated for 60 days with a hydroalcoholic extract of M. paniculata (MPE), at doses of 100, 200, and 400 mg/kg. MPE decreased glycemia and also cholesterol and triglyceride levels, starting 1 week after treatments, as compared with the same group before treatments. Glucose values were reduced toward normality after 1 week of treatment. MPE hypoglycemic effects were potentiated by glibenclamide and metformin. MPE also decreased fructosamine and glycated hemoglobin values. MPE reduced diabetes-induced morphological alterations of the kidney, pancreas, and liver. MPE acts similarly to glibenclamide and metformin, and its glucose-lowering action is partly a consequence of ATP-sensitive K channel inhibition. MPE may be a potential therapeutic alternative for the treatment of diabetes and its complications. Copyright © 2017 John Wiley & Sons, Ltd.

Hypoglycemic, Hypolipidemic, and Anti-Inflammatory Effects of Beta-Pinene in Diabetic Rats

“…Menezes et al [ 25 ] reported that species from the Fabaceae family contain several chemical substances in their composition, including α - and β -pinene, which caused a significant reduction in serum TG, TC, and high-density lipoprotein (HDL) levels in hyperglycemic rats treated with aqueous, ethanolic, and hexane leaf extracts from species belonging to this family. According to Menezes et al [ 26 ], diabetes promotes changes in plasma lipid concentration.…”

Influence of Extraction on the Yield, Phytochemical and LCMS Profile from Standardized Kemuning Leaf (Murraya paniculata (L.) Jack)

“…4 Murraya paniculata (L.) Jack belongs to the family of Rutaceae. 5 Murraya exotica Linn. synonym Murraya paniculata Linn Jack locally known as Kamini.…”

“…M. paniculata often grows in southern China (Hainan, Guangdong, Fujian, and Guangxi), India, Thailand, Malaysia, and Australia. 5 There are many reports on pharmacological effects of the plant including antinociceptive, antioxidant and anti-diabetic, to antimicrobial and analgesic activities. 7,8 Kemuning also showed the decrease in triglyceride, total and LDL cholesterol levels on rats.…”

“…3 Kemuning leaves (Murraya paniculata (L.) Jack) contain chemical compounds which are secondary metabolites such as essential oils, indole alkaloids, flavonoids, saponins, coumarins, and tannins. 2,5,8 The use of bioactive compounds in different commercial sectors such as pharmaceutical, food and chemical industries signifies the need of the most appropriate and standard method to extract these active components from plant materials. Extraction is the first step of any medicinal plant study, plays a significant and crucial role on the final result and outcome.…”

Complete chloroplast genome sequence of Murraya paniculata (Rutaceae): a widely used folk medicinal herb

“…Murraya paniculate (Rutaceae), is a folk medicinal plant widely used in Asia as antinociceptive, anti-inflammatory, and antioxidant. (Menezes et al 2017;Sharma et al 2017). However, only a few genomic resources have been explored.…”