Abstract:The effect of cytokines on non‐traditional immunological targets under conditions of chronic inflammation is an ongoing subject of study. Fatigue is a symptom often associated with autoimmune diseases. Chronic inflammatory response and activated cell‐mediated immunity are associated with cardiovascular myopathies which can be driven by muscle weakness and fatigue. Thus, we hypothesize that immune dysfunction‐driven changes in myocyte mitochondria may play a critical role in fatigue‐related pathogenesis. We sho… Show more
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