MicroRNA 200a as a histologically independent marker for meningioma recurrence: Results of a four microRNA panel analysis in meningiomas

Abstract

Introduction: Meningiomas are mostly benign neoplasms of the central nervous system. Nevertheless there are recurrences in about 20% after surgical resection. Previous studies could reveal several predictors of meningioma recurrence.Tumor progression often is associated with a specific pattern of chromosome losses. Our study investigated the potential function of selected microRNAs as markers of tumor progression.How to cite this article: Urbschat S, Landau B, Bewersdorf N-C, et al. MicroRNA 200a as a histologically independent marker for meningioma recurrence: Results of a four microRNA panel analysis in meningiomas.

MicroRNAs in meningiomas: Potential biomarkers and therapeutic targets

“…In a separate investigation, researchers explored the potential of selected microRNAs (miRNAs) as indicators of meningioma progression and recurrence [ 56 ]. Despite their initial benign nature, meningiomas can exhibit recurrence in approximately 20% of cases following surgical resection, emphasizing the need for markers to identify tumor progression and recurrence for improved patient management.…”

“…Despite their initial benign nature, meningiomas can exhibit recurrence in approximately 20% of cases following surgical resection, emphasizing the need for markers to identify tumor progression and recurrence for improved patient management. The study focused on analyzing specific miRNAs, namely miRNAs 21–3p, 34a-3p, 200a-3p, and 409–3p, in both solid tumor samples and blood samples obtained from meningioma patients [ 56 ]. This innovative approach, known as liquid biopsy, offers a non-invasive means of monitoring disease progression.…”

Noncoding RNA landscape and their emerging roles as biomarkers and therapeutic targets in meningioma

“…Interestingly, the blood samples of male meningioma patients compared with healthy controls revealed considerably high levels of miR-200a. 49 …”

“… 69 Recently, a unique study compared the expression patterns of select miRNAs (miR-21-3p, miR-34a-3p, miR-200a-3p, and miR-409-3p) in tumor and blood samples of meningioma patients (N = 51) with blood samples of healthy individuals (N = 20) and correlated these to the presence of aberrations of chromosomes 1, 14, 18, and 22 in native tumor tissue. 49 Loss of chromosome 1p has been previously identified as the most significant marker of recurrence in meningiomas, independent of histological grade. 70 In this study, miR-200a was proposed as a histologically independent marker for meningioma recurrence due to its significantly diminished expression in recurrent meningiomas and positive correlation with the presence of chromosomal aberration 1p.…”

“… 70 In this study, miR-200a was proposed as a histologically independent marker for meningioma recurrence due to its significantly diminished expression in recurrent meningiomas and positive correlation with the presence of chromosomal aberration 1p. 49 …”