<scp>O</scp>ccult <scp>H</scp>epatitis <scp>B V</scp>irus <scp>I</scp>nfection in <scp>J</scp>apanese <scp>C</scp>hronic <scp>H</scp>emodialysis <scp>P</scp>atients

Nagakawa, Osamu; Miyatomi, Yoshiho; Shigeta, Yasuhiro; Inayama, Emi; Murakami, Kazuhiko; Sakai, Takehiko; Kouno, Takashi; Masai, Motoyuki; Shirai, Kohji; Yoshida, Toyohiko

doi:10.1111/1744-9987.12006

Cited by 18 publications

(17 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Semelhante ao estudo em Juruti, uma investigação sobre a prevalência de IOB entre 1.401 pacientes e hemodialisados crônicos, do Japão oriental, encontrou 0,6% HBsAg+, com VHB-DNA+, entre os 212 pacientes HBsAg− com anti-HBc+; três amostras foram positivas para VHB-DNA, concluindo-se que a prevalência de IOB na amostra japonesa era de 0,3% 77 . Outro estudo sobre a prevalência de IOB entre 1.451 indivíduos australianos portadores de doença hepática encontrou 0,7% de pacientes que atendiam aos critérios de IOB 78 .…”

Section: Introductionunclassified

Infecção oculta pelo vírus da hepatite B em comunidade amazônica submetida a intenso fluxo migratório, estado do Pará, Brasil

Nunes¹,

Soares²,

Sarmento³

et al. 2017

Revista Pan-Amazônica de Saúde

View full text Add to dashboard Cite

The ones anti-HBc total+ isolated were selected, and from these the HBV DNA was investigated to identify OBI presence. RESULTS: In relation to HBV, the study showed 0.5% of carriers, 8.3% with a previous infection profile, 1.1% with a previous or current infection profile, and 33.6% with a vaccine response, characterizing that municipality as low endemicity for this virus. HBV DNA was detected in 66.7% of the HBsAg+ samples, with viral load between < 55 IU/mL and > 38,000 IU/mL; 69.2% of these samples were A1 subgenotype, 15.4% F2, and 15.4% F4. Of the total, 1.1% were samples from individuals anti-HBc total+ isolated whose molecular biology tests showed that 9.3% had HBV DNA, with viral load between < 15 IU/mL and 48 IU/mL. CONCLUSION: The findings of this study indicated the presence of OBI carriers in 0.1% of the Juruti population. The low prevalence of OBI found is probably related to the low endemicity of HBV in this population.

show abstract

Section: Introductionunclassified

Infecção oculta pelo vírus da hepatite B em comunidade amazônica submetida a intenso fluxo migratório, estado do Pará, Brasil

Nunes¹,

Soares²,

Sarmento³

et al. 2017

Revista Pan-Amazônica de Saúde

View full text Add to dashboard Cite

show abstract

“…OHB can be considered a significant problem in patients with chronic renal failure (CRF) being treated with renal replacement therapy (RRT) because they are susceptible to parenteral infection (due to permanent venous access and immunosuppression) and the possibility of reactivating infection when using immunosuppressants after renal transplantation . The prevalence of OHB in patients on hemodialysis is highly variable and has been related to the magnitude of the presence of chronic infection in the regions studied . The aim of this study was to determine the prevalence of OHB in patients on hemodialysis in São Luís, Maranhão state, Brazil.…”

Section: Introductionmentioning

confidence: 99%

Occult hepatitis B among patients with chronic renal failure on hemodialysis from a capital city in northeast Brazil

Fontenele

Gainer²,

Silva

et al. 2015

Hemodialysis International

View full text Add to dashboard Cite

Occult hepatitis B (OHB) is characterized by the presence of HBV-DNA in the absence of HBsAg in the serum of patients. Hemodialysis patients are at high risk for hepatitis B virus and there are few data on the prevalence of OHB in this population, mainly in Brazil. Thus, the aim of this study was to determine the prevalence of OHB in patients undergoing hemodialysis. A cross-sectional study was performed, including 301 patients on chronic hemodialysis at two dialysis centers in São Luís (Maranhão), northeast Brazil. Serological tests were performed for HBsAg, anti-HBc, anti-HBs, and anti-HCV using enzyme immunoassays (ELISA); HBV-DNA and HCV-RNA were studied by real-time PCR. The mean age was 49 ± 15 years, and 128 (42%) were female. Serological tests confirmed that all samples were HBsAg negative. Anti-HBc was positive in 114 (38%) patients, anti-HBc and anti-HBs were simultaneously positive in 104 (35%), and anti-HBc alone was positive in 10 (3%). Tests were negative for anti-HBc and anti-HBs in 55 patients (18%). Anti-HBs was the only positive marker in 132 (44%) patients. Anti-HCV was positive in 15 (5%) patients with HCV-RNA present in 14 of them (93%). HBV-DNA was positive in seven cases (2.3%). There was no association of HBV-DNA with age, gender, time on dialysis, previous kidney transplant, or HBV serological pattern, but there was a positive correlation with the presence of anti-HCV (P < 0.001). OHB in chronic renal failure patients on hemodialysis appears to be a relevant finding, suggesting that studying HBV-DNA in this population using sensitive molecular tests should be a recommended course of action, especially in candidates for renal transplant.

show abstract

“…In general, after HBsAg disappearance, HBsAb persists for life and confers long-term immunity. To our knowledge, all reported HD patients with OBI tested negative for HBsAb (1)(2)(3), and most of them exhibited an isolated anti-HBc pattern. We speculated that impaired immune function in chronic HD patients contributes to HBsAb negativity, thereby allowing HBV to replicate.…”

Section: Discussionmentioning

confidence: 90%

“…Written informed consent was obtained from the patient for genetic analysis of the IL36RN gene, and the work was approved by institutional ethical committee. It revealed a homozygous mutation of c.115 + 6 T > C (p.Arg10ArgfsX1) in IL36RN, which is one of the GPP-causing founder mutations in the Japanese (1). From these …”

Section: Discussionmentioning

confidence: 96%

See 1 more Smart Citation

Occult Hepatitis B Virus Infection With Increased Virus DNA Levels in a Chronic Hemodialysis Patient

2017

View full text Add to dashboard Cite

Occult Hepatitis B Virus Infection in Japanese Chronic Hemodialysis Patients

Cited by 18 publications

References 26 publications

Infecção oculta pelo vírus da hepatite B em comunidade amazônica submetida a intenso fluxo migratório, estado do Pará, Brasil

Infecção oculta pelo vírus da hepatite B em comunidade amazônica submetida a intenso fluxo migratório, estado do Pará, Brasil

Occult hepatitis B among patients with chronic renal failure on hemodialysis from a capital city in northeast Brazil

Occult Hepatitis B Virus Infection With Increased Virus DNA Levels in a Chronic Hemodialysis Patient

Contact Info

Product

Resources

About