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            flooring at home and uptake of phthalates in pregnant women

Shu, Huan; Jönsson, Bo; Gennings, Chris; Lindh, Christian; Nånberg, Eewa; Bornehag, Carl‐Gustaf

doi:10.1111/ina.12508

Cited by 30 publications

(17 citation statements)

References 49 publications

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“…[37] A Swedish study of 1,674 pregnant women showed that polyvinyl chloride ooring in the kitchen and the parents' bedrooms was associated with higher levels of urinary MBzP in the rst trimester. [38] In the present study, a positive correlation was only found between urinary MBzP concentrations and the development of AD in a meta-analysis. During the process of merging data for meta-analysis, the categorical scale of prenatal urinary phthalate exposure levels was converted to a continuous scale following Soomro et al [26] and Wang et al [30] The transformed OR might affect the overall results.…”

Section: Discussioncontrasting

confidence: 59%

Effect of Prenatal Phthalate Exposure on Childhood Atopic Dermatitis: a Systematic Review and a Meta-analysis of Birth Cohort Studies

Jung¹,

Kim²,

Kim³

et al. 2020

Preprint

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Background: The association between prenatal exposure to phthalate and childhood atopic dermatitis (AD) has been previously investigated; however, the results are inconsistent. We aimed to perform a systematic review and meta-analysis of birth cohort studies to investigate whether prenatal exposure to phthalate increases the risk of developing AD in children.Methods: We performed an electronic search of the MEDLINE, Embase, and Cochrane library databases. Studies were critically appraised, and meta-analyses were performed.Results: Among 129 articles identified, 11 studies met the eligibility criteria. Included studies originated from Europe (n = 5), USA (n = 4), and Asia (n = 2). The study sample size ranged from 147 to 1024 mother-child pairs. Quality assessment using the Newcastle–Ottawa scale of all studies had scores of six or greater. A meta-analysis of data from eight selected studies suggested that monobenzyl phthalate (MBzP) exposure was significantly associated with the risk of AD development (odds ratio 1.16, 95% confidence interval 1.04-1.31, I2 = 17.36%). However, AD development was not associated with other phthalate metabolites such as mono-(2-ethylhexyl) phthalate, monoethyl phthalate, mono-isobutyl phthalate, mono-n-butyl phthalate, and the sum of di-[2-ethylhexyl] phthalate on the development of AD (all P-values > 0.05).Conclusions: Our study suggests a positive association between prenatal exposure to MBzP and the development of childhood AD.

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Section: Discussioncontrasting

confidence: 59%

Effect of Prenatal Phthalate Exposure on Childhood Atopic Dermatitis: a Systematic Review and a Meta-analysis of Birth Cohort Studies

Jung¹,

Kim²,

Kim³

et al. 2020

Preprint

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“…PAEs are molecules that are not covalently linked to the matrix and show a tendency to migrate, especially in the presence of lipophilic compounds and/or in the event of mechanical or thermal stress [11]. For example, a generic product containing PVC (it may include more than 40% of DEHP) or other products containing such molecules produces a typical release of PAEs into the environment [12,13]. Therefore, PAEs represent ubiquitous contaminants and decompose with both exposure to sunlight and aerobic microbial activity; they tend to adsorb soil particles, sediments, and humus where they are protected from sunlight.…”

Section: Introductionmentioning

confidence: 99%

A Method Validation for Simultaneous Determination of Phthalates and Bisphenol A Released from Plastic Water Containers

et al. 2019

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Phthalates (or phthalate esters, PAEs) and bisphenol A (BPA) are widely used in various industries, particularly in the fields of cosmetics and packaging, and they increase the malleability and workability of materials. As a result of their use, some international health organizations have begun to study them. In this study, the authors developed a methodology for the simultaneous determination of dimethyl phthalate (DMP), diethyl phthalate (DEP), diisobutyl phthalate (DiBP); dibutyl phthalate (DBP), bis(2-ethylhexyl) phthalate (DEHP); di-n-octyl-phthalate (DnOP) and bisphenol A (BPA) from drinking and non-potable waters. The extraction of PAEs and BPA was performed using a solvent-based dispersive liquid–liquid microextraction (SB-DLLME) method. The analytical determination was performed using a gas chromatography–ion trap mass spectrometry (GC-IT/MS) analysis. The entire procedure was validated as recoveries were studied according to the volume and the extraction solvent used, pH, and ionic strength. Dynamic linearity ranges and linear equations of all the compounds were experimentally determined as well as the limit of detection (LOD) (1–8 ng mL−1) and the limit of quantification (LOQ) (5–14 ng mL−1), reproducibility, and sensitivity. The method was applied to 15 water samples (mineral water and tap water) for determining PAEs and BPA released from the plastic container. After the release simulation, four PAEs (i.e., DiBP, DBP, DHEP, and DnOP) were determined at very low concentrations (below 1.2 ng mL−1) in two water samples from (sport) bottles.

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“…WQS was specifically developed to assess the joint effect of a combination of chemicals measured as a mixture. Applications have included metals and organics [26, 27]. Consider a set of M correlated metal concentrations at a single time point that are grouped into quantiles, q m , and an outcome of interest y .…”

Section: Methodsmentioning

confidence: 99%

Time-varying associations between prenatal metal mixtures and rapid visual processing in children

et al. 2019

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BackgroundHumans are exposed to mixtures of chemicals across their lifetimes, a concept sometimes called the “exposome.” Mixtures likely have temporal “critical windows” of susceptibility like single agents and measuring them repeatedly might help to define such windows. Common approaches to evaluate the effects of chemical mixtures have focused on their effects at a single time point. Our goal is to expand upon these previous techniques and examine the time-varying critical windows for metal mixtures on subsequent neurobehavior in children.MethodsWe propose two methods, joint weighted quantile sum regression (JWQS) and meta-weighted quantile sum regression (MWQS), to estimate the effects of chemical mixtures measured across multiple time points, while providing data on their critical windows of exposure. We compare the performance of both methods using simulations. We also applied both techniques to assess second and third trimester metal mixture effects in predicting performance in the Rapid Visual Processing (RVP) task from the Cambridge Neuropsychological Test Automated Battery (CANTAB) assessed at 6–9 years in children who are part of the PROGRESS (Programming Research in Obesity, GRowth, Environment and Social Stressors) longitudinal cohort study. The metals, arsenic, cadmium (Cd), cesium, chromium, lead (Pb) and antimony (Sb) were selected based on their toxicological profile.ResultsIn simulations, JWQS and MWQS had over 80% accuracy in classifying exposures as either strongly or weakly contributing to an association. In real data, both JWQS and MWQS consistently found that Pb and Cd exposure jointly predicted longer latency in the RVP and that second trimester exposure better predicted the results than the third trimester. Additionally, both JWQS and MWQS highlighted the strong association Cd and Sb had with lower accuracy in the RVP and that third trimester exposure was a better predictor than second trimester exposure.ConclusionsOur results indicate that metal mixtures effects vary across time, have distinct critical windows and that both JWQS and MWQS can determine longitudinal mixture effects including the cumulative contribution of each exposure and critical windows of effect.

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PVC flooring at home and uptake of phthalates in pregnant women

Cited by 30 publications

References 49 publications

Effect of Prenatal Phthalate Exposure on Childhood Atopic Dermatitis: a Systematic Review and a Meta-analysis of Birth Cohort Studies

Effect of Prenatal Phthalate Exposure on Childhood Atopic Dermatitis: a Systematic Review and a Meta-analysis of Birth Cohort Studies

A Method Validation for Simultaneous Determination of Phthalates and Bisphenol A Released from Plastic Water Containers

Time-varying associations between prenatal metal mixtures and rapid visual processing in children

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