Screening and optimization of samarium-assisted complexation for the determination of norfloxacin, levofloxacin and lomefloxacin in their corresponding dosage forms employing spectrofluorimetry

Analytical methods for the determination of certain antibiotics used in critically ill patients

“…Multivariate strategy was utilized for developing a fluorescent technique for the estimation of norfloxacin, Levofloxacin and lomefloxacin in their pure and dosage forms. Based on their known interaction with lanthanides, and augmented fluorescence intensity obtained by antenna effect at λex/λem=314/553, 312/553 and 310/556 for NOR, LEV and LOM respectively [75] .…”

Electrochemical Determination of Fluoroquinolone Antibiotic Norfloxacin in the Presence of Anionic Surfactant Using the Anodically Pretreated Boron‐Doped Diamond Electrode

“…Quinolones that show antibacterial activity by blocking DNA synthesis are an important and widely used antibiotic class [8,9] . Norfloxacin (NFX) is the third‐generation synthetic fluoroquinolone antibiotic used in the treatment of various infections, especially urinary tract infections [10,11] . It performs its antibacterial activity on gram‐positive and gram‐negative bacteria by selectively blocking the DNA‐gyrase enzyme activity [4,12] .…”

“…[8,9] Norfloxacin (NFX) is the third-generation synthetic fluoroquinolone antibiotic used in the treatment of various infections, especially urinary tract infections. [10,11] It performs its antibacterial activity on gram-positive and gram-negative bacteria by selectively block-ing the DNA-gyrase enzyme activity. [4,12] Moreover, the antibacterial activity of this drug is thought to be related to the fluoride and piperazine moiety in its chemical structure (1-ethyl 6-fluoro-1,4-dihydro-4-oxo-7-(piperazinyl) quinolone-3-carboxylic acid, Figure 1).…”

“…[15] For this reason, NFX analyzes have attracted great attention for monitoring its quality control processes and for the determination the pollution level that occurs after drug use. Up to now, there have been numerous methods reported in the literature such as high performance liquid chromatography, [16][17][18][19][20][21] capillary electrophoresis, [22,23] UV spectrophotometry, [14,[24][25][26] luminescence spectrometry, [4,27,28] fluorescence spectrometry, [29,30] spectrofluorimetry, [11,15,31] electrochemical methods, [10,[32][33][34][35][36][37][38][39][40][41][42] and others. [5,43] Some of these methods are based on the degradation of the environmental contaminant that occurs after its use, [44][45][46] while some are directly focused to the monitoring of the relevant pollutant from environmental samples.…”

Poly(Taurine‐Glutathione)/Carbon Nanotube Modified Glassy Carbon Electrode as a New Levofloxacin Sensor

“…LEV containing pharmaceuticals are commonly used for the treatment of respiratory tract infections, skin infections and genitourinary tract infections . Quantitative determination of LEV has been studied by several analytical techniques such as spectrofluorimetry , nuclear magnetic resonance spectrometry , high‐performance liquid chromatography coupled with MS/MS , high performance liquid chromatography with photodiode array detector , UV spectrophotometric method and electrochemical technique . Nevertheless, the electrochemical methods are better than these mentioned techniques due to ease of operation, low cost, quick response time and high sensitivity.…”