Screening colonoscopy and risk of adverse events among individuals undergoing fecal immunochemical testing in a population‐based program: A nested case‐control study

Arana-Arri, Eunate; Imaz-Ayo, Natale; Fernández, Mari Jose; Idígoras, Isabel; Bilbao, Isabel; Bujanda, Luís; Bao, Fidencio; E, Ojembarrena; Gil, Inés; Gutiérrez-Ibarluzea, Iñaki; Portillo, Isabel

doi:10.1177/2050640618756105

Cited by 24 publications

(31 citation statements)

References 38 publications

(158 reference statements)

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“… 7 , 15 owever, few data exist on complications attributed to colonoscopy in an iFOBT-based screening program. 16 – 19 In a Spanish study that included 675 individuals having a colonoscopy after a positive iFOBT, the incidence of major complications was 1.5% (1.2% bleedings and 0.2% hypotension/bradycardia). 16 In the first round of the national CRC program in Slovenia, 13,919 individuals had a colonoscopy after a positive iFOBT, and the overall incidence of serious complications was 0.08% (0.05% perforations and .03% bleedings).…”

Section: Discussionmentioning

confidence: 99%

“… 16 In the first round of the national CRC program in Slovenia, 13,919 individuals had a colonoscopy after a positive iFOBT, and the overall incidence of serious complications was 0.08% (0.05% perforations and .03% bleedings). 17 From the Basque Country, Arana-Arri et al 19 reported a 1.0% overall complication rate based on an iFOBT screening program with 39,254 colonoscopies. Thus, our estimate of any complication (0.7%) is within the range of those reported from programs in Spain, Slovenia, and the Basque Country.…”

Section: Discussionmentioning

confidence: 99%

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Colonoscopy-related complications in a nationwide immunochemical fecal occult blood test-based colorectal cancer screening program

Mikkelsen¹,

Thomsen²,

Tybjerg³

et al. 2018

CLEP

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BackgroundThe Danish national screening program for colorectal cancer (CRC) consists of an immunochemical fecal occult blood test (iFOBT) followed by colonoscopy. The Danish Colorectal Cancer Screening Database (DCCSD) records data on the incidence of hospital-registered complications after colonoscopy. However, the validity of these data is unknown, and the incidence of complications is potentially underreported.ObjectiveTo evaluate the validity of the colonoscopy complications registered in the DCCSD by using medical records as the reference. Further, to evaluate the incidence of complications leading to hospital contact.MethodsAmong 14,671 individuals with a positive iFOBT result and a colonoscopy procedure performed from March 3, 2014 to December 31, 2014, we selected 295 individuals for medical record review. We calculated sensitivity as the proportion of true complications registered in the DCCSD out of all complications found in the medical records, and the positive predictive value (PPV) as the number of true complications in the DCCSD out of all DCCSD-registered complications. On the basis of the medical record data, we calculated the incidence proportion of hospital-registered complications overall and by subtype.ResultsIn total, we reviewed 286 records and found 102 individuals with at least one complication. The sensitivity of the DCCSD for any complication was 29.4% (95% CI: 20.8–39.3) and the PPV was 88.2% (95% CI: 72.6–96.7). On the basis of the medical record data, the incidence proportion of any complication after colonoscopy was 0.70% (95% CI: 0.57–0.84) and that of perforation or lesion was 0.10% (95% CI: 0.06–0.17); bleeding, 0.41% (95% CI: 0.31–0.53); post-polypectomy syndrome, 0.16% (95% CI: 0.10–0.24); and other medical complications, 0.04 (95% CI: 0.02–0.09).ConclusionThe DCCSD has low sensitivity for complications, and improvements in data registration are warranted. The incidence proportion of any hospital-treated post-colonoscopy complication was 0.70% in 2014, which was the first year of the Danish national CRC screening program. This is within the range of complications reported by other studies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Colonoscopy-related complications in a nationwide immunochemical fecal occult blood test-based colorectal cancer screening program

Mikkelsen¹,

Thomsen²,

Tybjerg³

et al. 2018

CLEP

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“…Çalışmamızda, toplamda 88 olguda (%29.3) herhangi bir patoloji izlenmemişken, 12 olguda (%4) KRK ve 120 olguda (%40) prekanseröz adenomatöz polipler saptanmıştır. Gaitada gizli kan testinin literatürde, kolon kanseri ve prekanseröz polip saptama sensitivitesini (duyarlılık) %64 olarak veren yayınlar vardır (10) . Çalışmamızdaki yüksek yalancı pozitifliğin nedeni, olasılıkla sağlık ocaklarında test öncesi bu durum ile ilgili hastaların yeterli bilgilendirilmemesi veya hastaların entelektüel ve eğitim düzeylerinin yetersiz olması olabilir.…”

Section: Discussionunclassified

Evaluation Of The Effectiveness Of Colon Cancer Screening Program Conducted in Our Region

Kara¹,

Sarıcı²,

Kalaycı³

2018

İKSST

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ÖZAmaç: Kolon kanseri tarama programı (KKTP) kapsamında birinci basamaktan kliniğimize yönlendirilen herhangi bir yakınması olmayıp GGK pozitifliği saptanan ardışık 300 olguya yapılan kolonoskopi sonuçları ile Sağlık Bakanlığınca bölgemizde yürütülen KKTP'nin etkinliğini araştırmayı amaçladık. Yöntem: Çalışmaya alınan bireylerin demografik özellikleri, kolonoskopi bulguları, patolojik tanıları ve tedavi sonuçları retrospektif olarak incelendi. Bulgular: Olguların 180'i kadın (%60), idi. On iki hastada (%4) kolorektal kanser (KRK) belirlendi. Bir hastada geniş tabanlı, sesil polipte yüksek grade displazili, tübülovillöz adenom saptandı. Bu 13 hastaya erken evrede laparoskopik olarak onkolojik prensiplere uygun cerrahi uygulandı. Toplamda 120 olguya prekanseröz adenomatöz polipler nedeni ile polipektomi uygulandı; bunların 30'unda (%10) yüksek gradeli displazi (YGD) saptandı. Kırkiki olguda (%14) benign anorektal hastalıklar (BAH) (fissür, hemoroid vb.) saptandı. Yirmi yedi (% 9) olguda divertiküler hastalık belirlendi. Patoloji sonucu ile 9 olguya (%3) ülseratif kolit ve 19 olguya (%6.3) nonspesifik kolit tanısı konuldu. Seksensekiz olguda (%29.3) normal kolonoskopik bulgular rapor edildi. Sonuç: Asemptomatik safhada kolon kanseri saptanan oniki ve bir geniş tabanlı YGD'li sesil polipli, olguya erken evrede cerrahi uygulanmıştır. Yüz yirmi olguda prekanseröz adenomatöz poliplere, polipektomi uygulanmış ve kolonoskopik takibe alınmıştır. Türkiyede KKTP'nin yaygınlaştırılması, etkin uygulanması ile erken teşhis ve tedavi oranlarının artacağı aynı zamanda KRK mortalite ve morbiditesinde önemli azalma olabileceği düşüncesindeyiz.Anahtar kelimeler: kolorektal kanser tarama programı, gaitada gizli kan, tarama kolonoskopisi, kolon polibi ABSTRACT Introduction: In order to search the success and efficacy of Colon Cancer Screening Program (CCSP), we aimed to evaluate the colonoscopic results of FOBT-positive 300 consecutive individuals that have been refered to our clinic within the scope of screening program. Method: Demographic features, colonoscopic findings, pathologic results, final diagnosis and treatment results of individuals were examined retrospectively. Results: A hundred and eighty (60%) individuals were women and 120 (40%) individuals were men. The median age of the individuals was 56 (50-70) years. Colorectal carcinoma (CRC) was detected in 12 (4%) patients. İn one patient tubulovillous adenoma with high grade dysplasia (HGD) was detected in broad-based sessile polyp. Laparoscopic surgery in compliance with oncologic principles was performed in these thirteen patients during the early stage of the disease. Precancerous adenomatous polyps were detected in 120 (40%), and high grade dysplasia (HGD) in 30 (10%) patients. In 42 individuals, benign anorectal diseases (fissure, hemorrhoids) were detected. Twenty-seven (9%) individuals had diverticulosis. According to pathologic results, nine (3%) patients were diagnosed as ulcerative colitis and nineteen (6.3%) patients as nonspecific colitis. Eighty-eight individua...

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“…The prevalence of colorectal adenomatous polyps varies greatly geographically [ 12 ]. Among asymptomatic individuals, the average risk of adenoma prevalence is about 10% in sigmoidoscopic studies and is more than 25% from colonoscopic findings [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of colonoscopy data for colorectal polyps and associated histopathological findings

Shahmoradi

Soleimaninejad

Sharifian

2020

Annals of Medicine and Surgery

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Background Adenomas of colon and rectal are frequent colonoscopically found benign lesions. The aim of this study is to evaluate the incidence of polyps among patients referred for colonoscopy and associated histopathological findings. Methods In this retrospective study, patients referred for colonoscopy at Shahid Madani Hospital from were enrolled. The records of the patients were evaluated for demographic data, polyp status along with size and location and type and histopathological findings of the polyps. The data obtained were statistically analyzed using SPSSv22. Results Among 1600 patients who underwent colonoscopy, 260 were positive with polyps. The main symptom among these patients was lower gastrointestinal bleeding 44.2%. The average size of the polyps was 5.68 ± 2.66 and the incidence was significantly greatest among the age group of 51–65 years, p < 0.01. The commonest sites polyps were sigmoid and descending colon, 28.6% and 23.2%, respectively. Adenomatous polyps were the most frequent type, 58.3%. The morphology and pathology of the polyps were significantly associated with each other, p < 0.01. Conclusion Our study evaluates the retrospective data for polyp findings among colonoscopy patients. Early diagnosis of polyps can provide better therapeutic outcomes.

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Screening colonoscopy and risk of adverse events among individuals undergoing fecal immunochemical testing in a population‐based program: A nested case‐control study

Cited by 24 publications

References 38 publications

Colonoscopy-related complications in a nationwide immunochemical fecal occult blood test-based colorectal cancer screening program

Colonoscopy-related complications in a nationwide immunochemical fecal occult blood test-based colorectal cancer screening program

Evaluation Of The Effectiveness Of Colon Cancer Screening Program Conducted in Our Region

Evaluation of colonoscopy data for colorectal polyps and associated histopathological findings

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