Screening for Anti‐Influenza Actives of Prefractionated Traditional Chinese Medicines

Kang, Qianli; Wang, Yanyan; Cui, Qinghua; Gong, Lili; Yang, Yong; Jiang, Haiqiang; Rong, Lijun; Rong, Rong; Du, Ruikun

doi:10.1155/2020/4979850

Cited by 9 publications

(8 citation statements)

References 31 publications

(32 reference statements)

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“…where g (i) is a window function of very short time and * is complex conjugate. When g (t) � 1, Vt, the short-time Fourier transform is converted to the traditional Fourier transform [16]. Continuous STFT has the fundamental property of being a linear time-frequency representation and having frequency-shift invariance.…”

Section: Extraction Of Signal Time-frequency Features Based Onmentioning

confidence: 99%

Lightweight Authentication Billing Enhancement Mechanism Based on the Fourier Fast Transform Algorithm

Zhou

Wang

2022

Mathematical Problems in Engineering

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In recent years, with the development and extensive application of Internet technology and computer technology, and under the role of the continuous expansion and enrollment expansion of colleges and universities, how to effectively solve the Internet problems faced by teachers and students in colleges and universities has gradually become an important problem that the university information management department should solve in time. In order to continuously improve the efficiency of Internet access in universities, the Internet authentication and billing system for universities proposed in this paper take J2EE as the development platform and combines RADIUS protocol and PPPoE protocol to provide users with diversified Internet billing methods and strategies. At the same time, based on the Fourier fast transform algorithm, the development environment for the Internet authentication and billing system for colleges and universities is deployed, and after the Internet authentication and billing system is implemented, from the functional point of view of the system, the main functional modules are designed and implemented, including the authentication management function. module, billing management function module. The experimental results have shown that the throughput of PPPoE access server in the campus network using the Fourier rapid transform algorithm for traffic load balancing delay is small and stable between 200 ms and 300 ms after the optimization, which provides a feasible solution to promote the healthy and harmonious development of the university campus network.

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Section: Extraction Of Signal Time-frequency Features Based Onmentioning

confidence: 99%

Lightweight Authentication Billing Enhancement Mechanism Based on the Fourier Fast Transform Algorithm

Zhou

Wang

2022

Mathematical Problems in Engineering

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“…As a mixture of various plant extracts, Chinese herbal formulae, such as Gegen Qinlian soup, Lianhua-qingwen capsule, and Yinqiao powder, have been shown to have potent antiviral activity in the clinic [ 104 , 105 , 106 ] ( Table 3 ).…”

Section: Development and Effects Of Influenza Antiviral Drugsmentioning

confidence: 99%

Development and Effects of Influenza Antiviral Drugs

et al. 2021

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Influenza virus is a highly contagious zoonotic respiratory disease that causes seasonal outbreaks each year and unpredictable pandemics occasionally with high morbidity and mortality rates, posing a great threat to public health worldwide. Besides the limited effect of vaccines, the problem is exacerbated by the lack of drugs with strong antiviral activity against all flu strains. Currently, there are two classes of antiviral drugs available that are chemosynthetic and approved against influenza A virus for prophylactic and therapeutic treatment, but the appearance of drug-resistant virus strains is a serious issue that strikes at the core of influenza control. There is therefore an urgent need to develop new antiviral drugs. Many reports have shown that the development of novel bioactive plant extracts and microbial extracts has significant advantages in influenza treatment. This paper comprehensively reviews the development and effects of chemosynthetic drugs, plant extracts, and microbial extracts with influenza antiviral activity, hoping to provide some references for novel antiviral drug design and promising alternative candidates for further anti-influenza drug development.

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“…This graph shows the Log HA titer levels analyzed by GLM. Glycyrrhiza glabra crude extract (1), Glycyrrhiza glabra methanol fraction (2), Glycyrrhiza glabra chloroform fraction (3), Myrtus communis crude extract (4), Myrtus communis methanol fraction (5), Myrtus communis chloroform fraction (6), Melissa officinalis crude extract (7), Melissa officinalis methanol fraction (8), Melissa officinalis chloroform fraction (9), Hypericum perforatum crude extract (10), Hypericum perforatum methanol fraction (11), Hypericum perforatum chloroform fraction (12), Tiliatilia platyphyllos crude extract (13), Tilia platyphyllos methanol fraction (14), Tilia platyphyllos chloroform fraction (15), Salix alba crude extract (16), Salix alba methanol fraction (17), Salix alba chloroform fraction (18), Camellia sinensis crude extract (19)…”

Section: Melissa Officinalismentioning

confidence: 99%

“…There are several plants used from ancient times till now for the treatment of common cold, flu syndrom and infections in throat and upper respiratory systems. Although there were many ethnopharmacology articles about them, a few reports highlighted their anti-influenza virus effects [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Potential antiviral effects of some native Iranian medicinal plants extracts and fractions against influenza A virus

Mehrbod

Safari

Mollai

et al. 2021

BMC Complement Med Ther

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Background Influenza A virus (IAV) infection is a continual threat to the health of animals and humans globally. Consumption of the conventional drugs has shown several side effects and drug resistance. This study was aimed to screen some Iranian medicinal plants extracts and their fractions against influenza A virus. Methods Glycyrrhiza glabra (rhizome), Myrtus commonis (leaves), Melissa officinalis (leaves), Hypericum perforatum (aerial parts), Tilia platyphyllos (flower), Salix alba (bark), and Camellia sinensis (green and fermented leaves) were extracted with 80% methanol and fractionated with chloroform and methanol, respectively. The cytotoxicity of the compounds were determined by MTT colorimetric assay on MDCK cells. The effective concentrations (EC50) of the compounds were calculated from the MTT results compared to the negative control with no significant effects on cell viability. The effects of EC50 of the compounds on viral surface glycoproteins and viral titer were tested by HI and HA virological assays, respectively and compared with oseltamivir and amantadine. Preliminary phytochemical analysis were done for promising anti-IAV extracts and fractions. Results The most effective samples against IAV titer (P ≤ 0.05) were crude extracts of G. glabra, M. officinalis and S. alba; methanol fractions of M. communis and M. officinalis; and chloroform fractions of M. communis and C. sinensis (fermented) mostly in co- and pre-penetration combined treatments. The potential extracts and fractions were rich in flavonoids, tannins, steroids and triterpenoids. Conclusion The outcomes confirmed a scientific basis for anti-influenza A virus capacity of the extracts and fractions from the selected plants for the first time, and correlated their effects with their phytochemical constituents. It is worth focusing on elucidating pure compounds and identifying their mechanism(s) of action.

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Screening for Anti‐Influenza Actives of Prefractionated Traditional Chinese Medicines

Cited by 9 publications

References 31 publications

Lightweight Authentication Billing Enhancement Mechanism Based on the Fourier Fast Transform Algorithm

Lightweight Authentication Billing Enhancement Mechanism Based on the Fourier Fast Transform Algorithm

Development and Effects of Influenza Antiviral Drugs

Potential antiviral effects of some native Iranian medicinal plants extracts and fractions against influenza A virus

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