Screening for cervical abnormalities associated with EBV, HPV and HSV-2 infections in South-West Nigeria: A tale between sex and non-sex workers

Okoye, Jude Ogechukwu; Ngokere, Anthony Ajuluchukwu; Erinle, Charles

doi:10.1016/j.jons.2018.07.001

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…This observation is in line with previous reports in Kenya and Nigeria and might probably be due to active sexual life, multiple sex partners and contact with commercial sex partners (44)(45)(46). Patients who agreed not to be sexually active had higher HSV-2 seropositivity than those who said they were sexually active and the only patient who had more than one partner was infected.…”

Section: Discussionsupporting

confidence: 91%

Seroprevalence of Herpes Simplex Virus Type Two in Patients Attending General Outpatient Clinic in Sokoto

Hudu¹,

Hamal²

2022

ABMS

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Introduction: The herpes simplex virus type 2 (HSV-2) infection is a common sexually transmitted illness with a large disease burden, with the largest disease burden in Sub-Saharan Africa. Researchers and policymakers can benefit from a source of detailed data on the prevalence of herpes simplex virus types 1 and 2 (HSV-1 and HSV-2). Objective: This study determined the seroprevalence of HSV-2 infection among patients presenting with fever at the specialist hospital Sokoto. Methodology: Commercial HSV type-1&-2 specific IgG Enzyme-Linked Immunosorbent Assay (ELISA) kits were used to analyse serum samples from 92 randomly selected patients. The association between infection and socio-demographic characteristics was determined using the Chi-square test using SPSS version 22 (IBM, Inc., Chicago, IL, USA). Results: The seroprevalence of HSV-2 was found to be 54.3% (n=50); antibodies to the virus were found in all of the patients. Male patients 21(67.7%) and single patients 23(63.9%) had a higher HSV-2 prevalence than married individuals who constituted 48% of the patients having seropositive HSV (P= 0.141). Those who did not practice protective sex had a higher seroprevalence of HSV-2 (52.8 %: 28/53). Conclusion: HSV-2 infection was found in more than half of the patients. It is therefore recommended that comprehensive, large nationally surveys should be carried out to guide policy and planning. Keywords: Sero-prevalence, HSV-2, Sokoto

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Section: Discussionsupporting

confidence: 91%

Seroprevalence of Herpes Simplex Virus Type Two in Patients Attending General Outpatient Clinic in Sokoto

Hudu¹,

Hamal²

2022

ABMS

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“…This finding indicates a significant risk of HPV exposure in this age group. Studies have also revealed an increased risk of HPV infection in commercial sex workers, who may also be at an increased risk for cervical abnormalities that develop into cervical cancermor [31][32][33] . This is not unrelated to their highrisk sexual behaviours, such as abusing substances during sex, not using barrier contraception and frequently engaging in extravaginal sex.…”

Section: Exposure Evaluationmentioning

confidence: 99%

Human papilloma virus infection and risks of developing cervical cancer: A review in the context of Nigerian situation

Olofinbiyi,

Gbala,

Fawole

et al. 2024

Int. J. Clin. Diagn. Pathol.

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Human Papillomavirus (HPV) infection poses a significant risk factor for the development of cervical cancer, particularly in regions with limited access to preventive measures. This study conducts a comprehensive assessment of the dose-response relationship between HPV infection and the subsequent risk of cervical cancer development in Nigeria. Exposure evaluation was conducted through an extensive review of epidemiological data, including HPV prevalence rates and cervical cancer incidence rates across various regions in Nigeria. The evaluation highlighted a notable correlation between the prevalence of HPV infection and the incidence of cervical cancer, suggesting a dose-response relationship. Risk characterization revealed that Nigerian women, particularly those in underserved communities, face a heightened risk of developing cervical cancer due to persistent HPV infection. Factors such as lack of awareness, limited access to screening programs and socioeconomic disparities further exacerbate this risk. Based on the findings, recommendations for mitigating the risk of cervical cancer in Nigeria include implementing widespread HPV vaccination programs targeting adolescent girls, enhancing access to cervical cancer screening and early detection services, and promoting public awareness campaigns on HPV infection and its link to cervical cancer. Additionally, efforts to improve healthcare infrastructure and address socioeconomic barriers are crucial for effectively reducing the burden of cervical cancer in Nigeria. This study underscores the urgent need for comprehensive strategies aimed at preventing HPV infection and reducing the incidence of cervical cancer in Nigeria, ultimately improving women's health outcomes nationwide.

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“…The higher prevalence of EBV+HSV-2 co-infection when compared with HPV+HSV-2 co-infection observed in recent studies suggest a higher odds for the former than the latter among women with abnormal Pap smears [21,22]. Elsheikh and colleagues reported a 10% and 2.4% prevalence of HPV+HSV-2 and EBV+HPV co-infections in cervical cancer cases, respectively [12].…”

Section: Ebv and Hsv-2 Co-infectionmentioning

confidence: 99%

Herpes Simplex Virus Type 2: Bystander or Active Player in Cervical Carcinogenesis?

Okoye

2018

JGWH

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Epstein-Barr virus (EBV) belongs to the group of gammaherpes viruses and is responsible for epithelial malignancies including B-cell lymphomas, lymphoproliferative disorders, nasopharyngeal, gastric and salivary gland carcinomas, breast, prostate and oral cancers. It is commonly transmitted through oral secretions. Previous studies demonstrated EBV DNA in cervicitis, precancerous (cervical intraepithelial neoplasia, CIN) and

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Screening for cervical abnormalities associated with EBV, HPV and HSV-2 infections in South-West Nigeria: A tale between sex and non-sex workers

Cited by 4 publications

References 17 publications

Seroprevalence of Herpes Simplex Virus Type Two in Patients Attending General Outpatient Clinic in Sokoto

Seroprevalence of Herpes Simplex Virus Type Two in Patients Attending General Outpatient Clinic in Sokoto

Human papilloma virus infection and risks of developing cervical cancer: A review in the context of Nigerian situation

Herpes Simplex Virus Type 2: Bystander or Active Player in Cervical Carcinogenesis?

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