Screening of antioxidant and antidiabetic activity from fruit bark, stem bark and leaves of Gyrinops versteegii (Gilg.) Domke

Abstract

Agarwood is a commodity that has many benefits for the community, one of which is as medicine. Gyrinops versteegi (Gilg.) Domke, as one of plant producing agarwood and an endemic plant in West Nusa Tenggara, has less information of biological activity. The present study aims to investigate the biological activities from G. versteegii, particularly for anti-oxidants and anti-diabetic activities and their cytotoxicity. The 1,1-diphenyl-2-picrylhydrazyl (DPPH)-radical scavenging activity assay was used to determine the anti-oxidant activity, whereas the α-glucosidase inhibition assay was conducted to determine the antidiabetic activity. The cytotoxicity test used brine shrimp lethality test (BSLT) and phytochemical analysis were also conducted. The highest anti-oxidant and antidiabetic activity was found in the methanol extract of leaves from infected G. versteegii with IC50 values of 32.89±2.7 and 55.01±2.4 μg/mL, respectively. The cytotoxicity test showed high toxicity with the LC50 value of 1.09 μg/mL. Therefore, their high activities showed that those extracts are potent for antioxidant and anti-diabetic agent.