Screening of Asymptomatic Women for Endometrial Cancer

Koss, Leopold G.; Schréiber, Klaus; Oberlander, Samuel G.; Moukhtar, M; Levine, Herbert S.; Moussouris, Harry F.

doi:10.3322/canjclin.31.5.300

Cited by 28 publications

(30 citation statements)

References 3 publications

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“…However, currently routine screening for endometrial cancer is not recommended in asymptomatic women, either for the premenopausal [14] or the postmenopausal population [2,5,6]. Some of the main justifications against its utilization are the poor positive predictive value of TVUS and the low incidence of endometrial cancer in asymptomatic postmenopausal women [15,16,17,18]. …”

Section: Discussionmentioning

confidence: 99%

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Endometrial Thickness in 1,500 Asymptomatic Postmenopausal Women Not on Hormone Replacement Therapy

Hartman

Wolfman

Nayot

et al. 2013

Gynecol Obstet Invest

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Objective: To determine the normal endometrial thickness (ET) on transvaginal ultrasound (TVUS) of asymptomatic postmenopausal women not on hormone replacement therapy. A subgroup that was determined to be suspicious for having an endometrial polyp was compared with the remainder. Methods: This prospective study selected 1,500 consecutive asymptomatic postmenopausal women receiving TVUS assessment from January to August 2010. ET was recorded. Results were divided into those with a normal-appearing lining (n = 1,399) and those suspicious for polyp (n = 101). Results for the entire sample were obtained and the groups were compared using independent samples t tests. Results: Of 1,500 women aged 45-95 years, 77.1% had an ET of ≤4 mm and 92% were ≤5 mm. Independent samples t tests were performed to compare the mean age and mean ET based on polyp status (i.e. with or without a possible polyp). There was a significant difference in mean age, 67.71 vs. 62.36 years (p < 0.01) and mean ET 8.02 vs. 3.40 mm (p < 0.01) between groups. Conclusions: 92% of asymptomatic postmenopausal women not on hormone replacement therapy had an ET of ≤5 mm. The mean ET was 3.71 ± 1.9 mm. However, a significant group, 6.7%, had an endometrial lining suspicious for polyp. These women had a significant increase in mean age and ET.

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Section: Discussionmentioning

confidence: 99%

“…A study by Koss et al [15] in 1981 screened 1,280 asymptomatic women aged 45 and older with endometrial sampling. Among them, 1,088 (85%) were postmenopausal and there were only 8 confirmed carcinoma cases (0.6%).…”

Section: Discussionmentioning

confidence: 99%

Endometrial Thickness in 1,500 Asymptomatic Postmenopausal Women Not on Hormone Replacement Therapy

Hartman

Wolfman

Nayot

et al. 2013

Gynecol Obstet Invest

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show abstract

“…17,18 The cystic dilation of endometrial glands and the amount of intervening stroma between glands are the most important parameters for classifying cystic and adenomatous hyperplasias, respectively. However, it is important to recognize that these are histologic, and not cytologic, parameters.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Efficacy of Endometrial Cytology with the Abradul Cell Sampler Supplemented by Laser Scanning Confocal Microscopy

et al. 1996

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“…Some studies reported that endometrial carcinoma may be diagnosed incidentally in asymptomatic women. [2][3][4][5][6] Most of these observations are only anecdotal. There has been only 1 large cohort study on endometrial screening in asymptomatic women 13 : a cohort of 2,586 asymptomatic women was screened and an incidence of 6.96 per 1,000 reported.…”

Section: Discussionmentioning

confidence: 99%

“…[2][3][4][5][6] Neither the staging of patients nor their outcome is mentioned, even in large cohort studies. 2,3 The aim of this study was to assess whether screening asymptomatic women is significant for the early detection of endometrial carcinoma. The mean age of the 21 asymptomatic patients was 51.2 years (range, 33-78), while that of the 421 symptomatic patients was 53.9 (24-83), revealing no significant difference.…”

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confidence: 99%