Screening of cyanobacteria and microalgae for their ability to synthesize silver nanoparticles with antibacterial activity

Patel, Vijay E.; Berthold, David E.; Puranik, Pravin R.; Gantar, Miroslav

doi:10.1016/j.btre.2014.12.001

Cited by 344 publications

(189 citation statements)

References 42 publications

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“…32,33 Bekasova et al 34 demonstrated the synthesis of AgNPs using RPE extracted from the red alga Callithamnion rubosum. Our data are consistent with these publications suggesting that phycobiliproteins are able to reduce PdCl 2 .…”

Section: Results and Discussion Synthesis And Characterization Of Pdnpsmentioning

confidence: 99%

Combination of palladium nanoparticles and tubastatin-A potentiates apoptosis in human breast cancer cells: a novel therapeutic approach for cancer

Yuan¹,

Peng²,

Gurunathan³

2017

IJN

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Background Breast cancer is the most common malignant disease that occurs in women. Histone deacetylase (HDAC) inhibition has recently emerged as an effective and attractive target for the treatment of cancer. The aim of this study was to investigate the efficacy of a combined treatment of tubastatin A (TUB-A) and palladium nanoparticles (PdNPs) against MDA-MB-231 human breast cancer cells using two different cytotoxic agents that work by two different mechanisms, thereby decreasing the probability of chemoresistance in cancer cells and increasing the efficacy of toxicity, to provide efficient therapy for advanced stage of cancer without any undesired side effects. Methods PdNPs were synthesized using a novel biomolecule called R-phycoerythrin and characterized using various analytical techniques. The combinatorial effect of TUB-A and PdNPs was assessed by various cellular and biochemical assays and also by gene expression analysis. Results The biologically synthesized PdNPs had an average size of 25 nm and were spherical in shape. Treatment of MDA-MB-231 human breast cancer cells with TUB-A or PdNPs showed a dose-dependent effect on cell viability. The combination of 4 μM TUB-A and 4 μM PdNPs had a significant inhibitory effect on cell viability compared with either TUB-A or PdNPs alone. The combinatorial treatment also had a more pronounced effect on the inhibition of HDAC activity and enhanced apoptosis by regulating various cellular and biochemical changes. Conclusion Our results suggest that there was a strong synergistic interaction between TUB-A and PdNPs in increasing apoptosis in human breast cancer cells. These data provide an important preclinical basis for future clinical trials on this drug combination. This combinatorial treatment increased therapeutic potentials, thereby demonstrating a relevant targeted therapy for breast cancer. Furthermore, we have provided the first evidence for the combinatorial effect and mechanism of toxicity of TUB-A and PdNPs in human breast cancer cells. The novelties of the study were identification of a combination therapy that consists of suitable therapeutic molecules that kill cancer cells and also exploration of two different possible mechanisms involved to reduce chemoresistance in cancer cells.

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Section: Results and Discussion Synthesis And Characterization Of Pdnpsmentioning

confidence: 99%

Combination of palladium nanoparticles and tubastatin-A potentiates apoptosis in human breast cancer cells: a novel therapeutic approach for cancer

Yuan¹,

Peng²,

Gurunathan³

2017

IJN

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“…The biosynthesis of nanoparticles via marine algae and other marine plants is a new and emerging research field. Several studies have shown these biological entities to have the potential to produce a wide range of metal and metal oxide nanoparticles using ecofriendly methods [118,119]. The following sections summarize and discuss currently available literature reports that have investigated a number of marine algae.…”

Section: Types Of Nanoparticles Produced By Marine Algae and Marine Pmentioning

confidence: 99%

A Review of Current Research into the Biogenic Synthesis of Metal and Metal Oxide Nanoparticles via Marine Algae and Seagrasses

Fawcett

Verduin

Shah

et al. 2017

Journal of Nanoscience

184

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Today there is a growing need to develop reliable, sustainable, and ecofriendly protocols for manufacturing a wide range of metal and metal oxide nanoparticles. The biogenic synthesis of nanoparticles via nanobiotechnology based techniques has the potential to deliver clean manufacturing technologies. These new clean technologies can significantly reduce environmental contamination and decease the hazards to human health resulting from the use of toxic chemicals and solvents currently used in conventional industrial fabrication processes. The largely unexplored marine environment that covers approximately 70% of the earth's surface is home to many naturally occurring and renewable marine plants. The present review summarizes current research into the biogenic synthesis of metal and metal oxide nanoparticles via marine algae (commonly known as seaweeds) and seagrasses. Both groups of marine plants contain a wide variety of biologically active compounds and secondary metabolites that enables these plants to act as biological factories for the manufacture of metal and metal oxide nanoparticles.

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“…Por otra parte para la fabricación biológica de NPs es posible utilizar cultivos de bacterias o cianobacterias (Patel et al, 2015), hongos (Ahmad et al, 2003), microalgas (Patel et al, 2015) o bien cultivos de células u órganos vegetales (AlShalabi y Doran 2013), plantas completas (Mittal et al, 2014) o sus estructuras, por ejemplo brotes (Gardea-Torresdey et al 2003), flores y tallos (Kuppusamy et al, 2016) o raíces (Pardha-Saradhi et al, 2014b). El proceso de fabricación biológica puede ocurrir de forma intracelular (Haverkamp and Marshall 2008), extracelular (Li et al, 2011) o inclusive ex planta por medio de los exudados radicales (Pardha-Saradhi et al, 2014a).…”

Section: Nanoparticles Biomanufacturingunclassified

“…Moreover for biological production of NPs can use cultures of bacteria or cyanobacteria (Patel et al, 2015), fungi (Ahmad et al, 2003), microalgae (Patel et al, 2015) or cell cultures or plant organs (Al-Shalabi and Doran 2013), whole plants (Mittal et al, 2014) or structures such outbreaks (Gardea-Torresdey et al, 2003), flowers and stems (Kuppusamy et al, 2014) or roots (PardhaSaradhi et al, 2014b). The manufacturing process may occur biological intracellularly (Haverkamp and Marshall 2008), extracellular (Li et al, 2011) or even ex plant via root exudates (Pardha-Saradhi et al, 2014A).…”

Section: Nanoparticles Biomanufacturingmentioning

confidence: 99%

Biofabricación de nanopartículas de metales usando células vegetales o extractos de plantas

Morales-Díaz

Juárez‐Maldonado²,

Morelos-Moreno

et al. 2017

Remexca

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ResumenSe presenta una revisión acerca de la biofabricación de nanopartículas (NPs) de metales usando extractos vegetales, cultivos celulares de órganos o bien plantas vivas. Se describen los dos métodos de biofabricación verde de nanopartículas: el proceso bioquímico con extractos y el proceso biológico que involucra células vivas. Se discute el mecanismo redox de biofabricación de NPs, haciendo énfasis en aquellos puntos que requieren mayor dilucidación con el propósito de estandarizar los procesos para adaptarlos a un sistema industrial de producción. Se describe igualmente lo que se conoce acerca del destino de las NPs biofabricadas en células vivas, remarcando el proceso de movilización extra-e intracelular así como entre diferentes tejidos y órganos de la planta. Se discuten por último los factores que regulan la tasa de biofabricación de nanopartículas en las células y tejidos vivos, dirigiendo la atención hacia aquello que se necesita dominar para obtener biofábricas para la producción de NPs en donde la variabilidad de tamaño, forma y reactividad se ajusten a estándares industriales.Palabras clave: balance redox, bioproducción, bioreducción de metales, síntesis química verde. AbstractA review is presented on the biomanufacturing of nanoparticles (NPs) of metals using plant extracts, cell organ cultures or live plants. The two methods of manufacturing green nanoparticles are described: the biochemical process extracts and biological process involving living cells. The redox mechanism biomanufacturing of NPs is discussed, emphasizing those points that require further clarification in order to standardize processes to adapt to an industrial production system. It also describes what is known about the fate of NPs biomanufacturing in living cells, highlighting the process of extra-and intracellular as well as between different tissues and organs of the plant mobilization. Finally the factors discussed that regulate the rate of biomanufacturing of nanoparticles in living cells and tissues, directing attention to what you need to master to obtain bio-factories for the production of NPs where the variability in size, shape and reactivity fit to industry standards.

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Screening of cyanobacteria and microalgae for their ability to synthesize silver nanoparticles with antibacterial activity

Cited by 344 publications

References 42 publications

Combination of palladium nanoparticles and tubastatin-A potentiates apoptosis in human breast cancer cells: a novel therapeutic approach for cancer

Combination of palladium nanoparticles and tubastatin-A potentiates apoptosis in human breast cancer cells: a novel therapeutic approach for cancer

A Review of Current Research into the Biogenic Synthesis of Metal and Metal Oxide Nanoparticles via Marine Algae and Seagrasses

Biofabricación de nanopartículas de metales usando células vegetales o extractos de plantas

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