Screening of immunomodulatory activity of total and protein extracts of some Moroccan medicinal plants

Daoudi, Abdeljlil; Aarab, Lotfi; Abdel‐Sattar, Essam

doi:10.1177/0748233711430972

Cited by 50 publications

(32 citation statements)

References 45 publications

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“…The plants tested were chosen based on our previous publications on assessments of a group of plants used in Moroccan traditional medicine for their immunomodulatory effects (Daoudi et al, 2012). The tested plants were classified into three groups; the first group includes Lepidium sativum L, Datura stramonium L and Delphinium staphysagria L. with an immuunostimulating effects.…”

Section: Choice Of Plantmentioning

confidence: 99%

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The Relationship Between Lectin Compounds and Immunomodulatory Activities of Protein Extracted From Plants

Daoudi¹,

Abdel-Satter²,

Aarab³

2013

JPS

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Lectins are carbohydrate-binding proteins of non-immune origin. They are essential components of plant active substances used by the plant in its system of defense and symbiotic interactions. It is expected that there is a relation between immunomodulatory activity of the protein extract and its content of lectin. In this study, we are aiming to explore the relation between the lectin content and the immunomodulatory activity using the erythroagglutination test of a group of immunomodulating protein plant extracts previously evaluated. The result shows that there is no relationship between the immunostimulatory activity and the presence or absence of lectins; lectins are not always immunostimulatory compounds; and they can also depressed immune activity. The erythro-agglutination is found qualitatively and quantitatively depending on the nature of lectin and its concentration in the protein extracted. Therefore, the lectin immunostimulatory effects found can also be used with an adjuvant effect in vaccine development; while, the lectin immunoinhibitory effects can be used in the cancer therapy.

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Section: Choice Of Plantmentioning

confidence: 99%

“…importance lectins is the object of this work. When we plan to investigate the relationship between the lectin existence and the nature of immunomodulatory activity of a different protein extracted from a group of Moroccan plants selected in the previous study (Daoudi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

The Relationship Between Lectin Compounds and Immunomodulatory Activities of Protein Extracted From Plants

Daoudi¹,

Abdel-Satter²,

Aarab³

2013

JPS

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“…Daoudi et al [97] studied the immunomodulatory activity of aqueous extract of 14 Moroccan medicinal plants including M. vulgare. Flower extract samples were tested for proliferation of immune cells using 3-(4, 5-dimethylthiazol2yl)-2, 5-diphenyltetrazolium bromide (MTT) assay on the splenocytes with or without stimulation by concanavalin-A, which is a mitogenic agent used as positive control.…”

Section: Immunomodulatory Activitymentioning

confidence: 99%

Marrubium vulgare L.: A review on phytochemical and pharmacological aspects

Lodhi¹,

Vadnere²,

Sharma³

et al. 2017

J Intercult Ethnopharmacol

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Marrubium vulgare L. (family: Lamiaceae), also known as the white horehound, is widely used as an herbal remedy for chronic coughs and colds. It is used in various disorders related to skin, liver, gastric, heart, and immune system. This review abridges phytochemical, pharmacological studies, and medicinal uses of M. vulgare and provides scientific proof for various ethnobotanical claims to identify gaps, which will give impulsion for novel research on M. vulgare based herbal medicines. This review summarizes selected scientific evidence on phytochemistry and pharmacological properties of M. vulgare over the past 48 years . Works related to M. vulgare was reviewed from various sources such as books, internet source, i.e., Google Search engine, PubMed, and Science Direct, and chemical abstract. The exhaustive literature was studied, and critical analysis was performed according to their phytochemical and pharmacological properties. Phytochemical investigations on different parts of M. vulgare have been reported the presence of flavonoids, steroids, terpenoids, tannins, saponins, and volatile oils (0.05%). The aerial parts contain marrubiin, together with ursolic acid and choline. Pharmacological activities such as antinociceptive, antispasmodic, antihypertensive, antidiabetic, gastroprotective, anti-inflammatory, antimicrobial, anticancer, antioxidant, and antihepatotoxic activity have been reported. M. vulgare has therapeutic potential in the treatment of inflammatory conditions, liver disorders, pain, cardiovascular, gastric, and diabetic conditions. Aerial parts of M. vulgare is a good source of labdane type diterpene especially marrubiin which is present in high concentrations. However, further scientific studies are needed to explore clinical efficacy, toxicity and to explore the therapeutic effect of major secondary metabolites such as diterpenes, phenylpropanoid, and phenylethanoid glycosides of M. vulgare.

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“…The main indications are for the treatment of diabetes, inflammatory disorders, dermatological problems and various type of infections. For centuries, the colocynth fruits have also been used for cancer treatment [53,56,57].…”

Section: African Folk Medicinementioning

confidence: 99%

Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine

et al. 2016

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Ribosome-inactivating proteins (RIPs) are enzymes that deadenylate nucleic acids and are broadly distributed in the plant kingdom. Many plants that contain RIPs are listed in the pharmacopoeias of folk medicine all over the world, mostly because of their toxicity. This review analyses the position occupied in traditional medicine by plants from which RIPs have been isolated. The overview starts from the antique age of the Mediterranean area with ancient Egypt, followed by the Greek and Roman classic period. Then, the ancient oriental civilizations of China and India are evaluated. More recently, Unani medicine and European folk medicine are examined. Finally, the African and American folk medicines are taken into consideration. In conclusion, a list of RIP-expressing plants, which have been used in folk medicine, is provided with the geographical distribution and the prescriptions that are recommended by traditional healers. Some final considerations are provided on the present utilization of such herbal treatments, both in developing and developed countries, often in the absence of scientific validation. The most promising prospect for the medicinal use of RIP-expressing plants is the conjugation of purified RIPs to antibodies that recognise tumour antigens for cancer therapy.

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Screening of immunomodulatory activity of total and protein extracts of some Moroccan medicinal plants

Cited by 50 publications

References 45 publications

The Relationship Between Lectin Compounds and Immunomodulatory Activities of Protein Extracted From Plants

The Relationship Between Lectin Compounds and Immunomodulatory Activities of Protein Extracted From Plants

Marrubium vulgare L.: A review on phytochemical and pharmacological aspects

Plants Producing Ribosome-Inactivating Proteins in Traditional Medicine

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