SD-OCT Imaging of Idiopathic Macular Holes With Spontaneous Closure

Scupola, Andrea; Tiberti, Alessandra; Sasso, Paola; Mastrocola, Alessandra; Berarducci, Antonio; Pantaleoni, F. Bozzoni; Dalt, Stefano Da; Balestrazzi, E.

doi:10.3928/15428877-20120216-01

Cited by 4 publications

(3 citation statements)

References 4 publications

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“…Forty-nine studies had complete data with a total of 181 eyes forming the basis of our analysis [Table 2]. [ 18 ][ 19 ][ 20 ][ 21 ][ 22 ][ 23 ][ 24 ][ 25 , 26 , 27 , 28 ][ 29 ][ 30 ][ 31 ][ 32 ][ 33 ][ 34 ][ 35 ][ 36 ][ 37 ][ 38 ][ 39 ][ 40 ][ 41 ][ 42 ][ 43 ][ 44 ][ 45 ][ 46 ][ 47 ][ 48 ][ 49 ][ 50 ][ 51 ][ 52 ][ 53 ][ 54 ][ 55 ][ 56 ] Mean vision improved significantly ( P

0.005) from 20/65 to 20/41 over a mean follow-up of two years. The median diameter of IFTMH was 166 with 81.1% being categorized as small holes.…”

Section: Resultsmentioning

confidence: 99%

Idiopathic Macular Hole: Algorithm for Nonsurgical Closure Based on Literature Review

M Mansour,

Parodi,

H Uwaydat

et al. 2023

JOVR

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Our purpose is to review the closure time and optical coherence tomography (OCT) biomarkers that result in the non-surgical repair of idiopathic full-thickness macular holes (IFTMH). Our methodology consisted of a comprehensive literature review of the nonsurgical resolution of IFTMH followed by the calculation of the estimated closure time using the structural equation model. Forty-nine studies were found eligible yielding 181 eyes with IFTMH: 81.1% being small holes (<250 μm) with a median diameter of 166 μm. Final vision (mean 20/41) was related to initial vision (mean 20/65) and mean age (67 years). The hole diameter was correlated with initial vision and closure time (mean 3.9 months). Closure time was related to hole diameter and initial vision in the following algorithm: Closure time (month)= −0.057 + 0.008 diameter (μm) + 0.021 age (year) + 2.153 initial vision (logMAR). Biomarkers by OCT for self-closure included in decreasing frequency: pointed edge, de-turgescence of cystic macular edema (CME) with reversal of bascule bridge, and vitreomacular traction (VMT) release. The crucial function of Muller cell bridging in sealing the hole attests to its exceptional capacity for regeneration. After the hole has begun to close; however in less than 5%, a delayed restoration of the ellipsoid layer or a persistent outer foveal defect may prevent visual recovery and reopening of the hole is possible. In conclusion, eyes with small-size IFTMH and good baseline vision can have the additional option of close OCT monitoring for biomarkers of self-sealing biomarkers. When rehabilitative activity seems to be lacking, surgery is therefore mandatory.

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0.005) from 20/65 to 20/41 over a mean follow-up of two years. The median diameter of IFTMH was 166 with 81.1% being categorized as small holes.…”

Section: Resultsmentioning

confidence: 99%

Idiopathic Macular Hole: Algorithm for Nonsurgical Closure Based on Literature Review

M Mansour,

Parodi,

H Uwaydat

et al. 2023

JOVR

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“…Spontaneous closure of macular holes has been reported by several authors, most cases being traumatic, but also in idiopathic cases. [7][8][9][10] Different theories have been proposed to explain the mechanism of spontaneous closure. Most studies state that fibrous tissue proliferation and bridging after the tangential traction of the posterior hyaloid is released, may play a major role in spontaneous closure, [8][9][10] but no consensus exists regarding the conditions whereby a macular hole closes even when vitreofoveolar adhesion persists.…”

Section: Discussionmentioning

confidence: 99%

“…[7][8][9][10] Different theories have been proposed to explain the mechanism of spontaneous closure. Most studies state that fibrous tissue proliferation and bridging after the tangential traction of the posterior hyaloid is released, may play a major role in spontaneous closure, [8][9][10] but no consensus exists regarding the conditions whereby a macular hole closes even when vitreofoveolar adhesion persists. Further work is needed to determine factors that could predict idiopathic macular hole spontaneous closure.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Closure of Simultaneous Idiopathic Macular Holes Documented by Spectral-Domain Optical Coherence Tomography

González-Cortés

Toledo-Negrete

Bages-Rousselon

et al. 2021

RETINAL Cases &Amp; Brief Reports

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Purpose: To report a case of spontaneous closure of simultaneous full-thickness macular hole.Methods: Case report and literature review.Results: A 67-year-old woman with small-diameter simultaneous macular holes was observed for a period of 5 months, and progression was documented with spectral-domain optical coherence tomography. Closure of right full-thickness macular hole was evidenced by 1 month and left full-thickness macular hole by 5 months. Conclusion:This case demonstrates possible spontaneous resolution of a condition that is usually treated surgically. A period of observation with serial imaging studies may be advised in cases of small macular holes.

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Macular hole closure following spontaneous release of vitreomacular traction

Özgönül

Besirli

2017

BMJ Case Reports

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We describe the temporal changes observed with spectral-domain optical coherence tomography (SD-OCT) in the left eye of a 65-year-old man who developed a stage 1 macular hole secondary to vitreomacular traction (VMT). After 1 month, VMT had resolved spontaneously with a complete posterior vitreous detachment. Following VMT resolution, macular hole demonstrated progressive improvement and outer retinal disruption recovered spontaneously. This report highlights the importance of observation before any intervention for cases of stage 1 macular hole associated with VMT.

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SD-OCT Imaging of Idiopathic Macular Holes With Spontaneous Closure

Cited by 4 publications

References 4 publications

Idiopathic Macular Hole: Algorithm for Nonsurgical Closure Based on Literature Review

Idiopathic Macular Hole: Algorithm for Nonsurgical Closure Based on Literature Review

Spontaneous Closure of Simultaneous Idiopathic Macular Holes Documented by Spectral-Domain Optical Coherence Tomography

Macular hole closure following spontaneous release of vitreomacular traction

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