Sea cucumbers with an anti-inflammatory effect on endothelial cells and subcutaneous but not on epicardial adipose tissue

Mena-Bueno, Sara; Atanasova, Miroslava; Fernández-Trasancos, Ángel; Paradela-Dobarro, Beatriz; Bravo, Susana B.; Álvarez, Ezequiel; Fernández, Ángel L.; Carrera, Iván; González-Juanatey, José Ramón; Eiras, Sonia

doi:10.1039/c5fo01246e

Cited by 15 publications

(7 citation statements)

References 39 publications

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“…Holothurians (Echinodermata: Holothuroidea), known as "sea cucumbers" or "beche-de-mer", are popular luxury food in Asia, called "trepang", and represent an economic important market as high value seafood products (Battaglene et al, 1999;Chen, 2004;Purcell et al, 2012a;Purcell et al, 2013). They are also used in traditional medicine for their nutritional virtues (Chen, 2004;Vergara & Rodriguez, 2016) and in medicine, pharmacology and in cosmetics for their bioactive compounds with anti tumoral, anti-oxidant and anti-inflammatory properties actually explored and valued (Janakiram et al, 2015;Kiew & Don, 2012;Kumar et al, 2007;Mena-Bueno et al, 2015;Santos et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

First description of embryonic and larval development, juvenile growth of the black sea-cucumber Holothuria forskali (Echinodermata: Holothuroidea), a new species for aquaculture in the north-eastern Atlantic

Laguerre

Raymond

Plan³

et al. 2020

Aquaculture

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Section: Introductionmentioning

confidence: 99%

First description of embryonic and larval development, juvenile growth of the black sea-cucumber Holothuria forskali (Echinodermata: Holothuroidea), a new species for aquaculture in the north-eastern Atlantic

Laguerre

Raymond

Plan³

et al. 2020

Aquaculture

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“…Holothurians have been attracting increasing interest for their high content of secondary metabolites with manifold potential applications, especially in the pharmaceutical field [2]. The biological potential of sea cucumbers ranges from antitumor to antimicrobial, anti-inflammatory and antiviral activities [3,4,5,6,7,8]. Moreover, it has been reported that sea cucumbers extracts may act as anticoagulant agents and inhibitors of hyperlipidemia [9,10].…”

Section: Introductionmentioning

confidence: 99%

Molecular Networking-Based Analysis of Cytotoxic Saponins from Sea Cucumber Holothuria atra

et al. 2019

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The saponin composition of a specimen of black sea cucumber, Holothuria atra collected in the Persian Gulf was studied by a combined approach including LC-MS/MS, Molecular Networking, pure compound isolation, and NMR spectroscopy. The saponin composition of Holothuria atra turned out to be more complex than previously reported. The most abundant saponins in the extract (1–4) were isolated and characterized by 1D- and 2D-NMR experiments. Compound 1 was identified as a new triterpene glycoside saponin, holothurin A5. The side chain of the new saponin 1, unprecedented among triterpene glycosides, is characterized by an electrophilic enone function, which can undergo slow water or methanol addition under neutral conditions. The cytotoxic activity of compounds 1–4, evaluated on the human cervix carcinoma HeLa cell line, was remarkable, with IC50 values ranging from 1.2 to 2.5 µg/mL.

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“…As reviewed recently, sea cucumber compounds can target the NF-κB signalling pathway, which is involved in inflammation, immunity, cellular differentiation, cell adhesion, and survival ( Wargasetia 2022 ). The extracts of Holothuria forskali and Parastichopus tremulus are reported to inhibit inflammation in endothelial cells ( Mena-Bueno et al, 2016 ). In a triple-blinded randomized controlled trial, the Stichopus horrens extract toothpaste can alleviate plaque-induced gingivitis, suggesting the anti-inflammatory effect of the sea cucumber compounds in human ( Bakar et al, 2020 ).…”

Section: The Sea Cucumber-devived Coumpounds For Treatment Of Cardiac...mentioning

confidence: 99%

Sea cucumber-derived compounds for treatment of dyslipidemia: A review

et al. 2022

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Dyslipidemias are disorders of plasma levels of lipids, such as elevated levels of total cholesterol and triglyceride, that are associated with various human diseases including cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD). Statins are the first-line drugs for treatment of dyslipidemia. However, a substantial proportion of patients cannot reach the recommended LDL-c level even with the highest tolerated doses of statins, and there is no available drug specifically for NAFLD therapy. Sea cucumbers are one of the widely distributed invertebrates, and are an important resource of food and medicine. Sea cucumbers have many valuable nutrients including saponins, fatty acids, phospholipids, cerebrosides, sulfated polysaccharides, as well as proteins and peptides. In recent years, these natural products derived from sea cucumbers have attracted attentions for treatment of CVD and NAFLD because of their lipid-lowering effect and low toxicity. However, the hypolipidemic mechanisms of action and the structure-activity relationship of these bioactive components have not been well-documented in literature. This review article summarizes the signaling pathways and the potential structure-activity relationship of sea cucumber-derived bioactive compounds including saponins, lipids, carbohydrates as well as peptides and proteins. This article will provide information useful for the development of sea cucumber-derived lipid-lowering compounds as well as for investigation of hypolipidemic compounds that are derived from other natural resources.

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Sea cucumbers with an anti-inflammatory effect on endothelial cells and subcutaneous but not on epicardial adipose tissue

Abstract: these results suggest that sea cucumber extracts might be used for the prevention of endothelial cells and SAT inflammation.

Cited by 15 publications

References 39 publications

First description of embryonic and larval development, juvenile growth of the black sea-cucumber Holothuria forskali (Echinodermata: Holothuroidea), a new species for aquaculture in the north-eastern Atlantic

First description of embryonic and larval development, juvenile growth of the black sea-cucumber Holothuria forskali (Echinodermata: Holothuroidea), a new species for aquaculture in the north-eastern Atlantic

Molecular Networking-Based Analysis of Cytotoxic Saponins from Sea Cucumber Holothuria atra

Sea cucumber-derived compounds for treatment of dyslipidemia: A review

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