Seasonal Modulation of Sebum Excretion

Piérard-Franchimont, C; Piérard, G.E.; Kligman, A.M.

doi:10.1159/000247853

Cited by 56 publications

(39 citation statements)

References 4 publications

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“…Skin temperature and the balance between the sebum molecular components affect the viscosity and rheology of lipids at the skin surface [62,73]. This could explain in part chronobiological variations in SER and FER including seasonal fluctuations [74] as well as the influence of ovarian [75,76] and perhaps other cycles of unknown periodicity [7]. A circadian rhythm has been found [63,77] with sebum output being greatest in the mid morning and minimal during the late evening and early morning hours.…”

Section: Factors Affecting Sebum Excretionmentioning

confidence: 99%

EEMCO Guidance for the in vivo Assessment of Skin Greasiness

Pierard

Piérard-Franchimont

Marks

et al. 2000

Skin Pharmacol Physiol

140

119

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Sebaceous gland activity has four distinct components which are sebum production (a secretion rate function), storage (a volume function), surface output (a delivery rate function) and stratum corneum permeation (an influx rate function). The oily appearance of skin results from an excess of sebum excretion and spreading over the body surface and its interaction with the skin surface. A multi-pronged approach is often useful to assess skin greasiness with precision. The clinical evaluation of skin greasiness and its shiny appearance should be further complemented by quantifying the large pores, follicular plugs and comedones. The sebum amount present at the skin surface can be measured non-invasively using one of several methods based on solvent extraction, cigarette paper pads, photometric assessment, bentonite clay and lipid-sensitive tapes. Quantitative parameters include the sebum casual level, the sebum excretion rate, the sebum replacement time, the instant sebum delivery, the follicular excretion rate, the density in sebum-enriched reservoirs and the sustainable rate of sebum excretion. A series of environmental and biological features influence the data. Hence rigorous methodological designs are mandatory to support claims. As a rule, accuracy of the methods is adversely affected by skin temperature, degree of hydration and surface roughness. An additional confounding factor is the inherent difficulty of collecting the surface lipids without a contribution from the follicular reservoir. A better understanding of factors that alter the sebum amount at the skin surface may well assist in the development of sebosuppressive agents to help the reduction of the skin greasiness and improve acne.

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Section: Factors Affecting Sebum Excretionmentioning

confidence: 99%

EEMCO Guidance for the in vivo Assessment of Skin Greasiness

Pierard

Piérard-Franchimont

Marks

et al. 2000

Skin Pharmacol Physiol

140

119

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“…With hyperthermia in humans, blood flow to the skin can increase from approximately 250 mL/min in thermoneutral environments to as much as 6 to 8 L/min or 60% of the cardiac output [70]. A heat exposure-induced increase in blood flow to the skin and the skin temperature could, in theory, increase: 1) the activity of skin enzymes; 2) the probability of enzymes catching toxic substances in the circulation; 3) sweat-mediated elimination of toxic substances, because water-soluble toxic substances can be excreted in sweat [10,11,53,54]; and 4) sebum-mediated elimination of circulating lipids and cholesterol, because sebum secretion is temperature-dependent [71-73]. All of these changes during heat exposure strengthen the body’s antioxidant defense and increase the excretion of circulating lipids and cholesterol.…”

Section: The Skin’s Antioxidant and Excretory Systemsmentioning

confidence: 99%

The skin function: a factor of anti-metabolic syndrome

Zhou

et al. 2012

Diabetol Metab Syndr

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The body’s total antioxidant capacity represents a sum of the antioxidant capacity of various tissues/organs. A decrease in the body’s antioxidant capacity may induce oxidative stress and subsequent metabolic syndrome, a clustering of risk factors for type 2 diabetes and cardiovascular disease. The skin, the largest organ of the body, is one of the major components of the body’s total antioxidant defense system, primarily through its xenobiotic/drug biotransformation system, reactive oxygen species-scavenging system, and sweat glands- and sebaceous glands-mediated excretion system. Notably, unlike other contributors, the skin contribution is variable, depending on lifestyles and ambient temperature or seasonal variations. Emerging evidence suggests that decreased skin’s antioxidant and excretory functions (e.g., due to sedentary lifestyles and low ambient temperature) may increase the risk for metabolic syndrome. This review focuses on the relationship between the variability of skin-mediated detoxification and elimination of exogenous and endogenous toxic substances and the development of metabolic syndrome. The potential role of sebum secretion in lipid and cholesterol homeostasis and its impact on metabolic syndrome, and the association between skin disorders (acanthosis nigricans, acne, and burn) and metabolic syndrome are also discussed.

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“…Die Drüsenlobuli sind von einem Gefäßnetz umgeben [20]. Die Aktivität und Entwicklung der Talgdrüse und der Sebumproduktion ist sowohl von hormonellen, saisonalen und klimatischen Faktoren abhängig [9,19,23,34].…”

Section: Talgdrüsenunclassified

DieTalgdrüse als Transporter für Vitamin E

Ekanayake‐Mudiyanselage

Thiele

2006

Hautarzt

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Human sebum is produced by sebaceous glands and reaches the skin surface via secretion through the hair shaft. There is experimental evidence that the sebaceous glands and sebum serve as a transport mechanism taking the lipophilic antioxidant vitamin E from the blood to the skin surface. The highest levels of vitamin E are found in the sebum and in the skin lipid film in sebum-rich areas such as facial skin. Recent studies indicate that daily oral supplementation of moderate doses of alpha-tocopherol for at least 3 weeks leads to significant increases of vitamin E levels in human skin sites with a high density of sebaceous glands, such as the face. Thus, the potential photoprotective and antioxidants effects of oral vitamin E, as well as possibly other antioxidants, are site-dependent. These findings should be considered when designing clinical studies to assess the efficacy of oral antioxidants against oxidative stress in the skin.

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Seasonal Modulation of Sebum Excretion

Cited by 56 publications

References 4 publications

EEMCO Guidance for the in vivo Assessment of Skin Greasiness

EEMCO Guidance for the in vivo Assessment of Skin Greasiness

The skin function: a factor of anti-metabolic syndrome

DieTalgdrüse als Transporter für Vitamin E

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