Seasonal variation of semen parameters correlates with environmental temperature and air pollution: A big data analysis over 6 years

Santi, Daniele; Magnani, Elisa; Michelangeli, Marco; Grassi, Roberto; Vecchi, Barbara; Pedroni, Gioia; Rovedatti, L.; Santis, Maria Cristina De; Baraldi, Enrica; Setti, Monica; Trenti, Tommaso; Simoni, Manuela

doi:10.1016/j.envpol.2018.01.021

Cited by 99 publications

(59 citation statements)

References 34 publications

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“…As we enter an era of elevated ambient temperatures associated with global climate change, we might anticipate an increased incidence of male infertility, as well as an elevated risk of a paternally-induced mutations in the offspring, as a consequence of oxidative DNA damage to the spermatozoa. It is already known that exposure to elevated summer temperatures suppresses human seminal quality and that oxidative stress is a major mediator of this change [104,105]. Such exposure will be of particular significance to livestock species where exposure to elevated ambient temperatures might not only suppress fertility but also disrupt the true breeding of selected genetic traits [106].…”

Section: Lifestyle Exposuresmentioning

confidence: 99%

The Importance of Oxidative Stress in Determining the Functionality of Mammalian Spermatozoa: A Two-Edged Sword

2020

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This article addresses the importance of oxidative processes in both the generation of functional gametes and the aetiology of defective sperm function. Functionally, sperm capacitation is recognized as a redox-regulated process, wherein a low level of reactive oxygen species (ROS) generation is intimately involved in driving such events as the stimulation of tyrosine phosphorylation, the facilitation of cholesterol efflux and the promotion of cAMP generation. However, the continuous generation of ROS ultimately creates problems for spermatozoa because their unique physical architecture and unusual biochemical composition means that they are vulnerable to oxidative stress. As a consequence, they are heavily dependent on the antioxidant protection afforded by the fluids in the male and female reproductive tracts and, during the precarious process of insemination, seminal plasma. If this antioxidant protection should be compromised for any reason, then the spermatozoa experience pathological oxidative damage. In addition, situations may prevail that cause the spermatozoa to become exposed to high levels of ROS emanating either from other cells in the immediate vicinity (particularly neutrophils) or from the spermatozoa themselves. The environmental and lifestyle factors that promote ROS generation by the spermatozoa are reviewed in this article, as are the techniques that might be used in a diagnostic context to identify patients whose reproductive capacity is under oxidative threat. Understanding the strengths and weaknesses of ROS-monitoring methodologies is critical if we are to effectively identify those patients for whom treatment with antioxidants might be considered a rational management strategy.

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Section: Lifestyle Exposuresmentioning

confidence: 99%

The Importance of Oxidative Stress in Determining the Functionality of Mammalian Spermatozoa: A Two-Edged Sword

2020

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“…Although a retrospective cohort study was conducted in Italy and suggested an effect of environmental temperature on sperm quantity, confounding variables such as demographic characteristics were not well controlled [15]. Similar results have been reported in 2018, a study using a big-data approach has shown that both maximum and minimum temperatures in the day of collection were negative related to semen parameters, and the relationship were also confirmed in the 30 and 60 days before collection, but not in the 90 days before collection [16]. Meanwhile, the opposite finding has been reported, Momen et al performed a prospective study and reported that semen parameters were also within normozoospermic levels when under high environmental temperature [17].…”

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confidence: 55%

The Association between Ambient Temperature and Sperm Quality in Wuhan, China

Wang

Tian

et al. 2020

Preprint

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Background Few epidemiological investigations have focused on the influence of environmental temperature on human sperm quality. Here, we evaluated the potential association between ambient temperature and human sperm quality in Wuhan, China, and examined the interactive effect of particulate matter (PM 2.5 ) and temperature. Methods 1780 males who had been living in Wuhan for no less than three months and received semen analysis at the Department of Reproductive Medicine in Renmin Hospital of Wuhan University between April 8, 2013 and June 30, 2015 were recruited. Daily mean meteorological data and air pollution data (PM 2.5 , O 3 and NO 2 ) in Wuhan between 2013 and 2015 were collected. A generalized linear model was used to explore the associations between ambient temperature and sperm quality (including sperm concentration, percentage of normal sperm morphology, and progressive motility) at 0–9, 10–14, 15–69, 70–90, and 0–90 days before semen examination, and the interaction between temperature and PM 2.5 . Results The associations between ambient temperature and sperm quality were an inverted U-shape at five exposure windows, except for a lag of 0–9 days for sperm concentration. A 1 °C increase in ambient temperature above the thresholds was associated with a 2.038 (1.292~2.783), 1.814 (1.217~2.411), 1.458 (1.138~1.777), 0.934(0.617~1.251) and 1.604 (1.258~1.951) decrease in the percentage of normal sperm morphology at lag 0–9, lag 10–14, lag 15–69, lag 70–90, and lag 0–90 days, respectively. The interaction p- values of PM 2.5 and temperature were mostly less than 0.05 at five exposure windows. When ambient temperature exposure levels were above the thresholds, a 0.979 (0.659-1.299) and 3.559 (0.251~6.867) decrease in percentage of normal sperm morphology per 1 °C increase in temperature at lag 0-90 days was observed in the PM 2.5 ≤ P 50 group and PM 2.5 > P 50 group, respectively. Conclusions Our results indicate that exposure to ambient temperature has a threshold effect on sperm quality, and PM 2.5 enhances the effect of temperature on sperm quality when temperatures are above the threshold.

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“…In the same context, there were several other studies focused on air pollution monitoring by Big Data analysis techniques [4,5,[12][13][14][15][16][17][18]. Some focused specifically on vehicular congestion [19][20], while others examined the adverse effects that occur in humans, such as infertility [21].…”

Section: Literature Reviewmentioning

confidence: 99%

Framework for Big Data integration in e-government

Martinez-Mosquera

Luján-Mora

2019

DYNA

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This article describes researches regarding Big Data integration in e‑government decision‑making, for instance, in areas like solar energy provisioning, environmental protection, agricultural and natural resources exploitation, health and social care, education, housing and transportation management, among others. These studies refer to regions that have integrated Big Data in e‑government, where South America is still in the early adoption stages. Hence, this study proposes three steppingstones for Big Data integration in e‑government decision‑making, production, management and application. The proposed framework aims to be a reference in South America for Big Data adoption in e‑government and thus help to mitigate the technology delay regarding other regions. Finally, a case study with open data obtained from the Instituto Nacional de Estadística y Censos of Ecuador (Ecuadorian Statistics and Census Agency) is presented.

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Seasonal variation of semen parameters correlates with environmental temperature and air pollution: A big data analysis over 6 years

Cited by 99 publications

References 34 publications

The Importance of Oxidative Stress in Determining the Functionality of Mammalian Spermatozoa: A Two-Edged Sword

The Importance of Oxidative Stress in Determining the Functionality of Mammalian Spermatozoa: A Two-Edged Sword

The Association between Ambient Temperature and Sperm Quality in Wuhan, China

Framework for Big Data integration in e-government

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