Seasonality of hip fracture and vitamin D deficiency persists in a sub‐tropical climate

Alvarez, Sonia E. Lara; Bell, Kate; Ward, Nicola; Cooke, Cameron; Inder, Warrick J.

doi:10.1111/imj.14391

Cited by 9 publications

(9 citation statements)

References 19 publications

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“…Notably, our finding of the positive association between warmer weather and injurious falls contrasts with other work reporting a higher risk of fall-related injuries in winter or colder seasons in both northern and southern hemispheres, possibly attributed to slipping on ice or snow [ 12 , 13 , 15 , 16 ]. One key difference is that these studies defined injury as a fracture, of which cases were often detected through medical records, while the present study emphasized all injuries, including bruising or pain, as reported via a monthly calendar.…”

Section: Discussioncontrasting

confidence: 99%

“…Specifically, understanding periods of the year associated with a higher risk for falling and lower levels of physical activity could guide individuals on how to preserve physical activity and prevent falls throughout the year. Prior work has suggested a relationship between weather and seasons with falls, fall-related injuries [ 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ], and physical activity [ 18 , 19 , 20 , 21 , 22 , 23 ]. However, literature describing how falls and physical activity vary across weather conditions and seasons is still limited.…”

Section: Introductionmentioning

confidence: 99%

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The Impact of Weather and Seasons on Falls and Physical Activity among Older Adults with Glaucoma: A Longitudinal Prospective Cohort Study

Vongsachang

Mihailović

Jian‐Yu

et al. 2021

Sensors

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Understanding periods of the year associated with higher risk for falling and less physical activity may guide fall prevention and activity promotion for older adults. We examined the relationship between weather and seasons on falls and physical activity in a three-year cohort of older adults with glaucoma. Participants recorded falls information via monthly calendars and participated in four one-week accelerometer trials (baseline and per study year). Across 240 participants, there were 406 falls recorded over 7569 person-months, of which 163 were injurious (40%). In separate multivariable regression models incorporating generalized estimating equations, temperature, precipitation, and seasons were not significantly associated with the odds of falling, average daily steps, or average daily active minutes. However, every 10 °C increase in average daily temperature was associated with 24% higher odds of a fall being injurious, as opposed to non-injurious (p = 0.04). The odds of an injurious fall occurring outdoors, as opposed to indoors, were greater with higher average temperatures (OR per 10 °C = 1.46, p = 0.03) and with the summer season (OR = 2.69 vs. winter, p = 0.03). Falls and physical activity should be understood as year-round issues for older adults, although the likelihood of injury and the location of fall-related injuries may change with warmer season and temperatures.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Impact of Weather and Seasons on Falls and Physical Activity among Older Adults with Glaucoma: A Longitudinal Prospective Cohort Study

Vongsachang

Mihailović

Jian‐Yu

et al. 2021

Sensors

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“…The prevalence of vitamin D deficiency is much higher in winter and spring than in summer and autumn, and there is evidence that the incidence of hip fracture is also higher in winter (24,25) . Our analyses do not account for season, as the hospital morbidity data do not present data stratified by season, but the proportion of winter hip fractures and falls hospitalisations attributable to vitamin D deficiency may be greater than that estimated here.…”

Section: Discussionmentioning

confidence: 99%

Hospitalisations for falls and hip fractures attributable to vitamin D deficiency in older Australians

et al. 2021

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Vitamin D deficiency is associated with increased risk of falls and fractures. Assuming this association is causal, we aimed to identify the number and proportion of hospitalisations for falls and hip fractures attributable to vitamin D deficiency [25 hydroxy D (25(OH)D) <50 nmol/L] in Australians aged 65 years and over. We used 25(OH)D data from the 2011/12 Australian Health Survey and relative risks from published meta-analyses to calculate population attributable fractions for falls and hip fracture. We applied these to data published by the Australian Institute of Health and Welfare to calculate the number of events each year attributable to vitamin D deficiency. In men and women combined, 8.3% of hospitalisations for falls (7991 events) and almost 8% of hospitalisations for hip fractures (1315 events) were attributable to vitamin D deficiency. These findings suggest that even in a sunny country such as Australia vitamin D deficiency contributes to a considerable number of hospitalisations as a consequence of falls and for treatment of hip fracture in older Australians; in countries where the prevalence of vitamin D deficiency is higher the impact will be even greater. It is important to mitigate vitamin D deficiency but whether this should occur through supplementation or increased sun exposure needs consideration of the benefits, harms, practicalities, and costs of both approaches.

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“…In addition, patients with hip fracture displayed lower calcium and increased alkaline phosphatase, which might signal presence of more osteomalaica in the hip fracture cohort. As several previous studies have demonstrated much lower vitamin D levels in hip fracture patients [2,[26][27]. The relationship between the serum levels of TMAO, vitamin D and hip fracture need to be elaborated in future research.…”

Section: Agingmentioning

confidence: 92%

Gut microbiota–dependent Trimethylamine N-Oxide are related with hip fracture in postmenopausal women: a matched case-control study

Liu

Guo

Meng

et al. 2020

Aging

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The study evaluates the serum levels of Trimethylamine N-Oxide (TMAO), a gut microbial metabolite, in 286 postmenopausal women with hip fracture. From January 1, 2018 to December 31, 2018, eligible patients were included. Same women without fracture mated age were enrolled. TMAO serum levels were tested by ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The serum levels of TMAO were significantly higher in patients with hip fracture than in those controls (P<0.001). The serum levels of TMAO were also higher in patients with hip fracture only than in those who also had upper limb fracture (P=0.001). High level of TMAO was proved a predictor of both hip fracture and had upper limb fracture combined hip fracture, after the adjustment of other existing risk factors [e.g., for each 1 uM increase of TMAO, odd ratio 1.16 (95% CI, 1.07-1.25), P < 0.001; and 1.12 (95% CI, 1.03-1.26), P=0.008, respectively]. In summary, increased TMAO serum levels associated with high risk of hip fracture, suggesting that increase TMAO may contribute to osteoporosis and fracture in postmenopausal women.

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Seasonality of hip fracture and vitamin D deficiency persists in a sub‐tropical climate

Cited by 9 publications

References 19 publications

The Impact of Weather and Seasons on Falls and Physical Activity among Older Adults with Glaucoma: A Longitudinal Prospective Cohort Study

The Impact of Weather and Seasons on Falls and Physical Activity among Older Adults with Glaucoma: A Longitudinal Prospective Cohort Study

Hospitalisations for falls and hip fractures attributable to vitamin D deficiency in older Australians

Gut microbiota–dependent Trimethylamine N-Oxide are related with hip fracture in postmenopausal women: a matched case-control study

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