Second-Derivative Spectrophotometric Determination of Some Benzenoid Drugs

Abdel-Khalek, Magdi M.; Abdel-Hamid, M. E.; Mahrous, Mohamed S.; Abdel-Salam, Mohamed

doi:10.1080/00032718508066176

Cited by 8 publications

(2 citation statements)

References 16 publications

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“…4 In pharmaceutical preparations, CNR is assayed by different methods including GC, 5 HPLC, [6][7][8] HPTLC, 9 electrochemical [10][11][12] and spectrophotometric methods. [13][14][15][16][17] Studies of the stability of CNR were also carried out spectrophotometrically. 18 Though the modern methods of analysis (HPLC, GLC, NMR and MS) for purity assay of any drug afford simplicity, speed, good specificity and excellent precision and accuracy, they involve sophisticated equipment, which are not in the reach of most laboratories and small-scale industries.…”

Section: Cinnarizine (Cnr) Is Chemically Called (E)-(diphenylmethyl)-mentioning

confidence: 99%

Determination of Cinnarizine in Pure and Pharmaceutical Formulations

Devagondanahalli

Shaikh

Seetharamappa

et al. 2007

J Chinese Chemical Soc

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Two simple, rapid and sensitive extractive spectrophotometric methods have been developed for the assay of cinnarizine (CNR) in pure and pharmaceutical formulations. The methods are based on the formation of chloroform soluble ion-association complexes of CNR with thymol blue (TB) and with cresol red (CR) in NaOAc-AcOH buffer of pH 3.6 for TB and in KCl-HCl buffer of pH 1.6 for CR with absorption maxima at 405 nm and at 403 nm for TB and CR, respectively. Reaction conditions were optimized to obtain the maximum color intensity. The systems obeyed Beer's law in the range of 0.6-15.8 and 0.8-16.6 mg mL -1 for TB and CR, respectively. Various analytical parameters have been evaluated and the results have been validated by statistical data.

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Section: Cinnarizine (Cnr) Is Chemically Called (E)-(diphenylmethyl)-mentioning

confidence: 99%

Determination of Cinnarizine in Pure and Pharmaceutical Formulations

Devagondanahalli

Shaikh

Seetharamappa

et al. 2007

J Chinese Chemical Soc

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“…[5][6][7] Uma revisão na literatura revela que existem inúmeros trabalhos sobre métodos analíticos para determinação de cinarizina em formulações farmacêuticas. Os métodos descritos empregam as técnicas de eletroforese capilar, 8 eletrocromatografia capilar, 9 cromatografia gasosa, 10,11 cromatografia líquida de alta eficiência, [12][13][14][15][16][17][18][19] cromatografia em camada delgada, 18 cromatografia em camada delgada de alta eficiência, 20,21 métodos eletroquímicos, [22][23][24][25][26] espectrofotometria, 16,17,19,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41] quimioluminescência, 42 fluorimetria 43,44 e espectrodensitometria. 19 Além dos métodos mencionados acima, ensaios de dissolução para comprimidos de cinarizina utilizando detecção potenciométrica ou por cromatografia líquida de alta eficiência também são descritos.…”

Section: Introductionunclassified

Estabelecimento de condições para ensaio de dissolução de cápsulas de cinarizina empregando planejamento fatorial

Gehring¹,

Santos²,

Pereira³

et al. 2011

Quím. Nova

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Recebido em 5/7/10; aceito em 21/10/10; publicado na web em 26/1/11 ESTABLISHMENT OF DISSOLUTION TEST CONDITIONS FOR CINNARIZINE IN PHARMACEUTICAL CAPSULES USING FACTORIAL DESIGN. This work describes the establishment of dissolution test conditions for 75 mg cinnarizine capsules using a multivariate approach. A 2 3 full factorial design was carried out to achieve the best conditions and HCl 0.1 mol L -1 as dissolution medium, basket as apparatus at 100 rpm and collect time at 30 min were considered adequate. The quantification was carried out by spectrophotometry at 251 nm. Both dissolution procedure and analytical method were validated and all parameters were within the acceptable limits. Since there is no official monograph for this pharmaceutical product, this dissolution test could be applied for quality control routine.

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