Second generation H1 - antihistamines interaction with food and alcohol—A systematic review

Paśko, Paweł; Rodacki, Tomasz; Domagała-Rodacka, Renata; Palimonka, Krzysztof; Marcinkowska, Monika; Owczarek, Danuta

doi:10.1016/j.biopha.2017.06.008

Cited by 40 publications

(24 citation statements)

References 57 publications

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“…AD patients may avoid alcohol because it generates an itch by increasing blood flow . Alternatively, the lower intake of alcohol may be because most patients (74.2%) used H 1 antihistamines to relieve pruritus; concomitant use of these medicines with alcohol may increase psychomotor impairment related to alcohol intake . Previous findings on alcohol intake in AD patients are conflicting; Siverberg et al .…”

Section: Discussionmentioning

confidence: 99%

Dietary habits in adult Japanese patients with atopic dermatitis

Ito

Morita

Okazaki

et al. 2019

The Journal of Dermatology

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Dietary habits can modulate the pathogenesis of atopic dermatitis. We evaluated these habits in adult Japanese patients with atopic dermatitis using a validated, brief‐type self‐administered diet history questionnaire and compared the results to those of age‐ and sex‐matched healthy controls. Patients with atopic dermatitis showed higher intakes of carbohydrate and potatoes and lower intakes of alcohol, niacin, meat and oils/fats compared with those of the healthy controls. The results of logistic regression analysis showed that the intake of alcohol was negatively associated with atopic dermatitis (odds ratio, 0.905; 95% confidence interval, 0.832–0.983; P = 0.0181). The intakes of vitamin B6 and fruit were positively correlated with the severity scoring of atopic dermatitis. Multiple regression analysis revealed that vitamin B6 intake was a predictor of the severity scoring of atopic dermatitis (β = 26.98508709, t = 2.3995292, P = 0.01933781). The intakes of vegetable fat, n‐6 polyunsaturated fatty acid, and confections were lower in the severe atopic dermatitis group (severity scoring of atopic dermatitis, ≥33) than those in the mild group. Atopic dermatitis is negatively associated with alcohol intake, and intake of vitamin B6 is a predictor of severity scoring of atopic dermatitis. The intake of n‐6 polyunsaturated fatty acid is lower in the severe atopic dermatitis group than that in the mild group. Further study is warranted on the relationships of these results with abnormal immune responses, impaired skin barrier or pruritus in atopic dermatitis.

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Section: Discussionmentioning

confidence: 99%

Dietary habits in adult Japanese patients with atopic dermatitis

Ito

Morita

Okazaki

et al. 2019

The Journal of Dermatology

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“…Bilastine is a second-generation H 1 -antihistamine. Although the efficacy of second-generation H 1 -antihistamines is generally similar, pharmacokinetic properties and the potential for drug-drug and food-drug interactions differ between individual drugs 9 . Bilastine has high specificity for H 1 -receptors and negligible affinity for other receptors, and demonstrates antihistamine and antiallergic properties 10,11 .…”

Section: Bilastine: Pharmacological Profilementioning

confidence: 99%

Bilastine: a lifetime companion for the treatment of allergies

Church

Tiongco-Recto

Ridolo

et al. 2019

Current Medical Research and Opinion

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Objective: Bilastine is a potent and highly selective H 1 -antihistamine approved for the treatment of allergic rhinoconjunctivitis and urticaria. This article summarizes available data on the use of bilastine in the treatment of allergic disorders in different age groups, including younger and older adults, and school-age children and adolescents. Methods: A PubMed literature search ("bilastine") was conducted on 25 February 2019. Additional literature known to the authors and identified from the reference lists of cited publications was included. Results: Bilastine is administered orally at a dose of 20 mg once daily in adults and adolescents aged 12 years and 10 mg once daily in children aged 6 to <12 years. Clinical trials have demonstrated its efficacy at improving nasal and ocular symptoms in patients with allergic rhinitis, and wheals and itching in patients with urticaria. It has a rapid onset of action and long duration of action. Bilastine does not undergo significant metabolism and does not interact with the CYP450 system, which limits its potential for drug-drug interactions. No dosage adjustments are required in patients with renal or hepatic impairment, or in the elderly. Bilastine is generally well tolerated, even when administered at above-standard doses. It does not exhibit anticholinergic effects or cardiotoxic effects, shows no central nervous system penetration and has minimal sedative properties. It has been shown to improve health-related quality of life. Conclusions: Bilastine is a suitable option for the treatment of patients with allergic rhinoconjunctivitis or urticaria across age groups from school-age children to elderly patients.

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“…It plays an important role in modulating allergy reactions and immune system responses. H1 receptor is a therapeutic target for drugs applied in allergic diseases such as allergic rhinconjunctivitis, urticarial, or atopic dermatitis . They are also used in the treatment of asthma, high fever and rhinitis .…”

Section: Introductionmentioning

confidence: 99%

“…As many aquatic systems are increasingly dominated by or dependent on effluent discharge of differential quality, chronic antihistamine exposures to non‐target species must be considered in these urbanizing surface waters . Moreover, H1 antihistamines from water sources produce drug–food and alcohol–drug interactions to cause anticholinergic side effects . Therefore, it is necessary to detect antihistamines in water sources and increase the safety level of the drug.…”

Section: Introductionmentioning

confidence: 99%

High performance liquid chromatography associated with resonance Rayleigh scattering for synchronous determination of three antihistamines and mechanism study

Peng

Chen

et al. 2018

Luminescence

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A highly sensitive and selective method of high performance liquid chromatography (HPLC) combined with resonance Rayleigh scattering (RRS) spectra was developed for the detection of three antihistamine drugs, including pyrilamine (PY), carbinoxamine (CAR) and tripelennamine (TRI). The three antihistamines were separated by a C18 column. The mobile phase contained 25% acetonitrile (ACN) and 75% phosphate buffered solution (pH 3.2) with the flow rate of 0.4 ml min . In medium of Britton-Robinson (BR) buffer solution (pH 4.6), the PY, CAR and TRI separated by HPLC and then reacted with Erythrosine B (EryB), forming 1:1 ion-association complexes, which led to significant signal enhancement of RRS spectra. The RRS spectra was detected at the wavelength λ =λ = 370 nm. The calibration curves of PY, CAR and TRI were linear in the range from 0.02 to 25 μg ml , and the detection limit [signal-to-noise ratio (S/N) = 3] were 3.38, 4.48 and 5.50 ng ml , respectively. In addition, under the optimum experiment condition, the reaction mechanism and the reasons for RRS enhancement were investigated in this work. The developed method was applied to the simultaneous detection of three antihistamines in water samples with satisfying results.

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Second generation H1 - antihistamines interaction with food and alcohol—A systematic review

Cited by 40 publications

References 57 publications

Dietary habits in adult Japanese patients with atopic dermatitis

Dietary habits in adult Japanese patients with atopic dermatitis

Bilastine: a lifetime companion for the treatment of allergies

High performance liquid chromatography associated with resonance Rayleigh scattering for synchronous determination of three antihistamines and mechanism study

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