Secondary closure of posterior continuous curvilinear capsulorhexis

Tassignon, Marie-José; Groot, Veva De; Smets, R; Tawab, B.; Vervecken, Filip

doi:10.1016/s0886-3350(96)80068-x

Cited by 48 publications

(33 citation statements)

References 18 publications

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“…The finding was verified cytologically. In a study of adults (Tassignon et al 1996) secondary closure also occurred after posterior continuous curvilinear capsulorhexis. In an in vitro study the posterior capsulorhexis became closed by lens epithelial cells proliferating on a basal lamina produced by themselves or of vitreous origin (DeGroot et al 1998).…”

Section: Discussionmentioning

confidence: 97%

Complications after early surgery for congenital cataracts

Lundvall

Zetterström

1999

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: To study the type and frequency of complications requiring additional surgery in infants operated on for congenital cataract before 12 months of age. Methods: The medical records of 57 infants who underwent surgery for unilateral and bilateral congenital cataracts during a five-year-period were reviewed retrospectively. The follow-up period ranged from 9 to 70 months with a mean of 37 months. Cataract extraction was performed on 83 eyes. Results: Thirty-eight operations for after-cataracts were performed on 32 out of 83 eyes. Fourteen vitrectomies were made on 11 eyes because of pupillary block glaucoma. Glaucoma requiring trabeculectomy developed in eight eyes 2 to 14 months after cataract extraction. This type of glaucoma occurred almost exclusively in eyes operated on during the first two months of life. Conclusion: Complications requiring additional surgery are very common in infants operated on for congenital cataracts during the first year of life. Glaucoma requiring trabeculectomy developed particularly in infants who had their cataract extraction very early. Glaucoma development was not more common in infants operated on for after-cataract.Key words: infant -cataract surgery -complications -aphakic glaucoma -after-cataract.Acta Ophthalmol. Scand. 1999: 77: 677-680 Copyright c Acta Ophthalmol Scand 1999. ISSN 1395-3907 C ataract is the most important cause of treatable childhood blindness (Foster et al. 1997). The visual outcome in infants undergoing surgery for congenital cataract has improved dramatically since the advent of modern surgical techniques and the realisation that early intervention and immediate optical correction can prevent otherwise irreversible deprivation amblyopia (Taylor 1979;Jacobson et al. 1981). However, it is extremely important that the cataract extraction and the correction of aphakia are performed early -within the first months of life Rogers et al. 1981;Gelbart et al. 1982;Parks 1982;Birch & Stager 1988;Drummond et al. 1989;Kugelberg 1992). It is also important to diagnose and treat complications such as after-cataract and secondary glaucoma as soon as possible to avoid deprivation amblyopia or damage of the optic nerve. Both open-angle and closedangle glaucoma occur after successful surgery for congenital cataracts and the incidence remains alarmingly high (Phelps & Arafat 1977;Keech et al. 1989;Simon et al. 1991;Mills & Robb 1994).The aim of this retrospective study was to determine the type and incidence of complications requiring additional surgery in infants who had undergone cataract extraction prior to 12 months of age. Material and MethodsThe medical records of all infants who underwent surgery for congenital cataract before 12 months of age at St. Erik's Eye Hospital during the five-year period from October 1991 to August 1996 were reviewed retrospectively. Seventy-five percent of the operations were performed by the same surgeon, the remaining twenty-five percent by three other surgeons.The surgical technique of the cataract extraction was th...

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Section: Discussionmentioning

confidence: 97%

Complications after early surgery for congenital cataracts

Lundvall

Zetterström

1999

Acta Ophthalmologica Scandinavica

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“…The standard treatment for PCO is neodymium: YAG laser capsulotomy, which has been associated with considerable ophthalmic risks and is rather expensive [1]. Several techniques have been advocated for PCO prevention, including improved surgical techniques and improved intraocular lens (IOL) design and material [4][5][6], application of pharmacological and immunological agents [7,8], coating of IOLs with substances inhibiting LEC proliferation [9] and posterior continuous circular capsulorhexis [10][11][12]. However, despite these efforts, PCO still occurs in a considerable percentage of patients.…”

Section: Introductionmentioning

confidence: 99%

A Preliminary Study on the Prevention of Posterior Capsule Opacification by Photodynamic Therapy with Bacteriochlorin <i>A</i> in Rabbits

et al. 2002

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Purpose: Photodynamic therapy (PDT) with bacteriochlorin a (BCA) has proven to be successful in the treatment of cancers and to be cytocidal for lens epithelial cells (LECs) in culture. The present study aimed to determine whether PDT with BCA is also effective in destroying LECs in the capsular bag in vivo and could therefore be a strategy for prevention of posterior capsule opacification (PCO). Materials and Methods: BCA was obtained by saponification and acid hydrolysis of bacteriochlorophyll a and was formulated in 30% polyethylene glycol, 20% ethanol and 50% water. Nine albino rabbits were anesthesized and both pupils dilated. Extracapsular lens extraction by phacoemulsification was performed on both eyes. One eye of each animal served as control. In the other eye, 1.5 ml BCA (10 or 50 µg/ml) was injected in the capsular bag and after 10 min, the eye was illuminated with a diode laser (wavelength 760 nm) for 10 or 15 min. Six weeks after surgery, the rabbits were sacrificed and the globes were enucleated, the capsular bags and the corneas removed, fixed and examined using stereomicroscopy and light microscopy. Results: In the control capsular bags, extensive proliferation of LECs and formation of a complete ring of Soemmering was found, while in the PDT-treated capsular bags, LEC proliferation was markedly diminished and an incomplete irregular and much thinner ring of Soemmering was formed. Using the presently described application, the corneas of the PDT-treated animals were opaque and swollen and had lost their endothelial lining. Conclusion: PDT with BCA induces cell death in LECs and greatly reduces the formation of a ring of Soemmering. Therefore, it could be a promising novel means of prevention of PCO, provided the total length of the treatment can be substantially reduced and the negative effects on corneal transparency avoided.

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“…The standard treatment for PCO is Neodymium : YAG laser capsulotomy, which has been associated with considerable ophthalmic risks and is quite expensive (Apple et al, 1992). Several techniques have been advocated for PCO prevention, including improved surgical methods and appropriate intraocular lens (IOL) design (Sterling and Wood, 1986;Born and Ryan, 1990;Yamada et al, 1995), application of pharmacological and immunological agents (Legler et al, 1993;Power, Neylan and Collum, 1994), coating of IOLs with substances inhibiting LEC proliferation and posterior continuous circular capsulorhexis (PCCC) (Galand, Van Cauwenberge and Moosavi, 1996;Tassignon et al, 1996;Van Cauwenberge, Rakic and Galand, 1997). However, despite these efforts, PCO still occurs in a considerable number of patients.…”

Section: Introductionmentioning

confidence: 99%