Secondary metabolites ofAspergillussp. F1, a commensal fungal strain ofTrewia nudiflora

Abstract

Twelve compounds that belonged to five structure types, namely saturated dibenzylbutyrolactone lignans (1-3), sesterterpenoids (4-6), anthraquinone (questin, 7), benzophenone (dihydrogeodin, 8) and diphenyl ethers (9-12), were isolated from the extract of the strain Aspergillus sp. F1, which was isolated from the seeds of Trewia nudiflora. Among them, compounds 1, 11 and 12 were determined to be new, namely butylrolactone-V, butyl 2,4-dichloroasterrate and methyl 2,4-dichloroasterrate, respectively. The structures of these compounds were characterised on the basis of spectroscopic data.

Terretonin G, a new sesterterpenoid antibiotic from marine-derived Aspergillus sp. OPMF00272

“…Analysis of the 1 H-1 H COSY spectra revealed two partial structures C-1 to C-2 and C-9 to C-11 ( Figure 2). The 13 C-1 H long range couplings of 2J and 3J observed in the 13 The cross peak from 15-OCH 3 (d 3.52) to C-15 (d 173.0) supported the partial structure III. (4) The cross peaks from 14-H to C-15 and from 24-H 3 to C-16 indicated that the partial structures I, II and III are connected as shown in Figure 2.…”

Three New Compounds from Aspergillus terreus PT06-2 Grown in a High Salt Medium

“…This assignment was further supported by 1 H- 1 H COSY correlation between H-1‴ and H-2‴, and HMBC correlations from H-1‴ to C-2′, C-4′ and C-3‴, from H-4‴/5‴ to C-2‴ and C-3‴ (Figure 2). The dextral specific rotation ([α] 25 D +71) indicated R -configuration at C-4 [17]. Thus, the structure of terrelactone ( 3 ) was determined as ( R )-methyl 4-hydroxy-2-(4-hydroxy-3-(3-hydroxy-3-methylbutyl)benzyl)-3-(4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-2-carboxylate.…”

Open-Ring Butenolides from a Marine-Derived Anti-Neuroinflammatory Fungus Aspergillus terreus Y10

“…The structures of compounds 5 – 11 were elucidated by the comparison of their MS and NMR data with those reported in literature, and they were identified as: butyrolactone II ( 5 ) [ 19 ], butyrolactone IV ( 6 ) [ 10 ], butyrolactone III ( 7 ) [ 20 ], butyrolactone IX ( 8 ) [ 21 ], 3-hydroxy-5-[[4-hydroxy-3-(3-methyl-2-buten-1-yl) phenyl] methyl]-4-(4-hydroxyphenyl)-(5 H )-furan-one ( 9 ) [ 6 ], 5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-butenyl) phenyl] methyl]-3-(4-hydroxyphenyl)-5-oxo-furancarboxylic acid) ( 10 ) [ 22 ], butyrolactone I ( 11 ) [ 23 ]. Their 1 H and 13 C NMR were provided in Tables S1 and S2 in the Supplementary Materials .…”