Secondary neuroendocrine carcinomas of the skin

Skin Metastasis of Neuroendocrine Carcinoma Derived from the Mediastinum

“…Generally, the most common neoplasm of skin metastases is melanoma (44.8%), fol- al. (2) reported seven cases of metastatic neuroendocrine carcinoma, and found that the primary site of six cases was the lung, and that of the remaining case was the thymus. Our present case of skin metastasis of a neuroendocrine carcinoma from the mediastinum is very rare.…”

Serum neuron‐specific enolase in metastatic merkel cell tumors

“…Merkel cell tumors are recognized as locally aggressive skin carcinomas which occasionally produce metastatic disease [15]. Despite the rarity of hematogenous dissemination in Merkel cell tumors, our three patients all appear to have had widely metastatic disease.…”

Multiple cutaneous metastases of neuroendocrine carcinoma derived from the uterine cervix

“…Cutaneous histological findings of undifferentiated small‐cell carcinoma with neuroendocrine features can be seen in Merkel cell carcinoma or in secondary metastasis from some visceral origin. The primary sites of origin include the lung, 2 larynx, 3 mediastinum, 4 uterus, 1 and thymus 5 . Microscopically, organoid clusters, trabeculae, and sheets of small hyperchromatic cells with scant cytoplasm, and round‐to‐angulated nuclei, characterize the architectural patterns of growth 5 .…”

“…The primary sites of origin include the lung, 2 larynx, 3 mediastinum, 4 uterus, 1 and thymus 5 . Microscopically, organoid clusters, trabeculae, and sheets of small hyperchromatic cells with scant cytoplasm, and round‐to‐angulated nuclei, characterize the architectural patterns of growth 5 . To confirm neuroendocrine features, an immunohistochemical study using neuroendocrine markers such as CD56, synaptophysin, NSE, and chromogranin A is of pivotal importance and is indeed mandatory in these types of neoplasms.…”