Secondhand Smoke Exposure and Quality of Life in Patients With Heart Failure

Weeks, Sarah; Glantz, Stanton A.; Marco, Teresa De; Rosen, Alisa B.; Fleischmann, Kirsten E.

doi:10.1001/archinternmed.2011.518

Cited by 23 publications

(14 citation statements)

References 31 publications

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“…Old age is a strong independent predictor of death and morbidity in patients with structural heart disease. Therefore, old age is a major risk factor with poor cardiovascular outcome and reduced endogenous cardioprotection 5 . Both the incidence and the severity of atherosclerosis and cardiovascular disease increases with age.…”

Section: Introductionmentioning

confidence: 99%

Secondhand Smoke Exposure Reduced the Compensatory Effects of IGF-I Growth Signaling in the Aging Rat Hearts

Wu¹,

Hsieh²,

Kuo

et al. 2015

Int. J. Med. Sci.

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Background: Secondhand smoke (SHS) exposure is associated with increased risk of cardiovascular disease. Aging is a physiological process that involves progressive impairment of normal heart functions due to increased vulnerability to damage. This study examines secondhand smoke exposure in aging rats to determine the age-related death-survival balance.Methods: Rats were placed into a SHS exposure chamber and exposed to smog. Old age male Sprague-Dawley rats were exposed to 10 cigarettes for 30 min, day and night, continuing for one week. After 4 weeks the rats underwent morphological and functional studies. Left ventricular sections were stained with hematoxylin-eosin for histopathological examination. TUNEL detected apoptosis cells and protein expression related death and survival pathway were analyzed using western blot.Results: Death receptor-dependent apoptosis upregulation pathways and the mitochondria apoptosis proteins were apparent in young SHS exposure and old age rats. These biological markers were enhanced in aging SHS-exposed rats. The survival pathway was found to exhibit compensation only in young SHS-exposed rats, but not in the aging rats. Further decrease in the activity of this pathway was observed in aging SHS-exposed rats. TUNEL apoptotic positive cells were increased in young SHS-exposed rats, and in aging rats with or without SHS-exposure.Conclusions: Aging reduces IGF-I compensated signaling with accelerated cardiac apoptotic effects from second-hand smoke.

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Section: Introductionmentioning

confidence: 99%

Secondhand Smoke Exposure Reduced the Compensatory Effects of IGF-I Growth Signaling in the Aging Rat Hearts

Wu¹,

Hsieh²,

Kuo

et al. 2015

Int. J. Med. Sci.

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“…Inflammation may also play an important role in heart failure outcomes. 12 Physicians should advice patients with heart failure and their families to avoid exposure to SHS. Moreover, the implementation of smoke-free legislations was related to reductions in acute coronary event hospitalizations in most populations evaluated and it's reinforce the urgent need to enact and enforce smoke-free legislations that protect all citizens.…”

Section: Discussionmentioning

confidence: 99%

“…11 Other study also report that exposure to SHS in people with heart failure was associated with generally lower HRQoL scores in univariate analysis, with statistically and clinically significant reductions in 3 subscale scores: role physical, emotional well-being and role emotional. 12…”

Section: Secondhand Smoke and Hrqolmentioning

confidence: 99%

Association of Secondhand Smoke (SHS) Exposure with Health-Related Quality of Life (HRQOL): A Systematic Review

Kristina¹,

Permitasari²

2018

SRP

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Secondhand smoke (SHS) has been well established as one of risk factor for many diseases. Although exposure to SHS has been associated with various medical conditions, the evidence on the effect of it on healthrelated quality of life (HRQoL) is still limited. Therefore, the objective of this study is to examine the association between SHS with HRQoL. Terms and keywords relevant to secondhand smoking behaviors and HRQoL were used in a search of the electronic database. Three electronic databases (PubMed, Science Direct, Cochrane Database of Systematic Reviews) and Google Scholar were used. Searches were limited to English language, included papers: a) had clearly defined measures of SHS exposure and b) had clearly defined measures of outcome variables related to HRQoL. A total of 42 studies were initially retrieved and reviewed. After further review of references from the retrieved studies, 8 studies were finally selected that met all eligibility criteria. The reviewed studies consisted of three cross-sectional study analyses, two cohort studies, one longitudinal analysis and one study using bivariable and multivariable analysis. Those findings consisted of varied number of population and conducted from different countries. Exposure to SHS was associated with generally lower HRQoL, suggesting that detrimental effects of SHS exposure on HRQoL are not limited to patients with diseases (chronic disease, COPD, or heart failure) but also in healthy never smoking children and adult, both in man and woman. Our review study showed that SHS exposure towards healthy or people with disease, children, adult, both in man and woman were associated with decreased HRQoL. It can provide new evidence for stronger smoke-free policies on public places and promoting smoke-free homes.

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“…5 6 19 20 Studies that examined the association between SHS exposure and physical functioning were mostly restricted to patient samples with inconclusive findings. [21][22][23] To our best knowledge, only one study examined the association between SHS exposure and HRQoL in the Swiss general population, which showed that SHS was associated with a significant decrease in HRQoL scores with a dose-response relationship. 24 Hong Kong is the most economically developed city of China with the most stringent tobacco control policy including comprehensive smoke-free legislation, raising tobacco tax, banning tobacco advertisings and promotions, and providing smoking cessation services.…”

Section: Introductionmentioning

confidence: 99%

Secondhand smoke exposure (SHS) and health-related quality of life (HRQoL) in Chinese never smokers in Hong Kong

Chen

Wang

et al. 2015

BMJ Open

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ObjectiveThe evidence on the effect of secondhand smoke (SHS) on Health Related Quality of Life (HRQoL) is limited. We examined the relation between SHS and HRQoL among Chinese in Hong Kong.MethodsAdult never smokers from a probability sample of three cross-sectional waves (2010, 2012, 2013) of The Hong Kong Family and Health Information Trends Survey who completed the Cantonese-version of Short-Form 12 Health Survey Questionnaire (SF12v2) were included in the data analysis conducted in 2014. Models were used to examine associations of SHS with SF12 domains and summary scores of Physical (PCS12) and Mental Component (MCS12) with subgroups analysis by SHS locations.ResultsAfter adjustments, SHS was associated with lower scores on all SF12 domains except physical functioning. PCS12 (regress coefficient=−0.76, 95% CI −1.34 to −0.17) and MCS12 (regress coefficient=−1.35, 95% CI −2.06 to −0.64) were lower in those with SHS exposure than those non-exposed. Those exposed to SHS in outdoor public places had lower scores on most SF12 domains and PSC12 and MCS12. SHS exposure in one's home and workplace was associated with lower scores on role physical, body pain and role emotional while SHS exposure in friends’ homes was additionally associated with lower social functioning and mental health scores. Lower MCS12 was associated with SHS exposure at all locations except one's home.ConclusionsOur study showed that SHS exposure, particularly in outdoor public places, was associated with decreased HRQoL. It can provide new evidence for stronger smoke-free policies on public places and promoting smoke-free homes.

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Secondhand Smoke Exposure and Quality of Life in Patients With Heart Failure

Abstract: Even low levels of SHS are associated with lower scores in several aspects of HRQOL. Physicians should advise patients with heart failure and their families to avoid SHS exposure.

Cited by 23 publications

References 31 publications

Secondhand Smoke Exposure Reduced the Compensatory Effects of IGF-I Growth Signaling in the Aging Rat Hearts

Secondhand Smoke Exposure Reduced the Compensatory Effects of IGF-I Growth Signaling in the Aging Rat Hearts

Association of Secondhand Smoke (SHS) Exposure with Health-Related Quality of Life (HRQOL): A Systematic Review

Secondhand smoke exposure (SHS) and health-related quality of life (HRQoL) in Chinese never smokers in Hong Kong

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