Secretome analysis of rat adipose tissues shows location-specific roles for each depot type

Roca-Rivada, Arturo; Alonso, Jana; Al‐Massadi, Omar; Castelao, Cecilia; Peinado, Juan R.; Seoane, Luísa M.; Casanueva, Felipe F.; Pardo, María

doi:10.1016/j.jprot.2011.03.010

Cited by 68 publications

(58 citation statements)

References 43 publications

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“…SAT or IMF), and in part between their components (stromal vascular fraction vs. mature adipocytes), in human, rat, cattle and pig. All of these studies confirmed different protein profiles depending on anatomical location and implied different functionality of the adipose depots 79-84. Most of the proteins which were enriched in the VAT proteomes compared to SAT were related to stress response and inflammation in human as well as in cattle 80, 83.…”

Section: Depot Specific Properties Of Adipose Tissuesupporting

confidence: 52%

Molecular Heterogeneities of Adipose Depots - Potential Effects on Adipose-Muscle Cross-Talk in Humans, Mice and Farm Animals

Komolka¹,

Albrecht²,

Wimmers³

et al. 2014

J. Genomics

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Adipose tissue is considered as a major endocrine organ that secretes numerous proteins called adipokines. The heterogeneous nature of adipose tissue in different parts of the body suggests respective heterogeneity of proteomes and secretomes. This review consolidates knowledge from recent studies targeting the diversity of different adipose depots affecting the pattern of secreted adipokines and discusses potential consequences for the cross-talk between adipose and skeletal muscle in humans, rodent models and farm animals. Special attention is paid to muscle-associated fat depots like inter- and intramuscular fat that become focus of attention in the context of the rather new notion of skeletal muscle as a major endocrine organ. Understanding the complexity of communication between adipocytes and skeletal muscle cells will allow developing strategies for improvement of human health and for sustainable production of high quality meat.

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Section: Depot Specific Properties Of Adipose Tissuesupporting

confidence: 52%

Molecular Heterogeneities of Adipose Depots - Potential Effects on Adipose-Muscle Cross-Talk in Humans, Mice and Farm Animals

Komolka¹,

Albrecht²,

Wimmers³

et al. 2014

J. Genomics

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“…Examples include adiponectin, omentin-1, CTRP9, and Sfrp5. Most adipokines have been identified in visceral and/or subcutaneous adipose tissue, which seem to produce different profiles of secreted proteins 46, 124–126 , which may play a role in the above-discussed different contribution of these fat depots to cardiometabolic risk. However, in addition to these depots, the body exhibits other smaller fat depots in association with multiple organs, including heart, kidneys, bone marrow, lungs and blood vessels (Figure 1).…”

Section: Adipokines and Cardiovascular Diseasementioning

confidence: 99%

Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease

Fuster

Ouchi

Gokce

et al. 2016

Circulation Research

516

391

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Obesity is causally linked with the development of cardiovascular disorders. Accumulating evidence indicates that cardiovascular disease is the “collateral damage” of obesity-driven adipose tissue dysfunction that promotes a chronic inflammatory state within the organism. Adipose tissues secrete bioactive substances, referred to as adipokines, which largely function as modulators of inflammation. The microenvironment of adipose tissue will affect the adipokine secretome, having actions on remote tissues. Obesity typically leads to the upregulation of pro-inflammatory adipokines and the downregulation of anti-inflammatory adipokines, thereby contributing to the pathogenesis of cardiovascular diseases. In this review, we focus on the microenvironment of adipose tissue and how it influences cardiovascular disorders, including atherosclerosis and ischemic heart diseases, through the systemic actions of adipokines.

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“…In the last few years, considerable focus has been put on the signals generated by peripheral tissues, such as fat (Catalan et al, 2009;Foresta et al, 2010;Friedman, 2002;Roca-Rivada et al, 2011), stomach (Al-Massadi et al, 2010;Kojima et al, 1999), or the distal intestine (Wynne et al, 2004), that act centrally to regulate body weight. In this context, the skeletal muscle has recently been postulated to be an endocrine organ able to release protein/peptide signals, termed myokines, that regulate several physiological and metabolic pathways (Pedersen and Febbraio, 2012;Roca-Rivada et al, 2012).…”

mentioning

confidence: 99%

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

Crujeiras

Pardo

Roca-Rivada

et al. 2013

American J Hum Biol

Self Cite

129

117

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Objective: The recently discovered peptide irisin has been hypothesized to be a regulator of body metabolism. The objective of this work was to evaluate whether circulating human irisin levels are modulated by body size and changes in adiposity during an energy restriction treatment and the subsequent weight regain.Methods: A group of 94 obese patients (50 men, 44 women; 49.4 6 9.4 years; BMI 35.6 6 4.5 kg/m 2 ) participated in a weight loss program following an 8-week hypocaloric diet (230% energy expenditure) with a weight maintenance follow-up. The patients were evaluated at 0, 8, and 24 weeks after starting treatment. In addition, 48 normal-weight subjects (16 men, 32 women; 35.71 6 8.8 years; BMI 22.9 6 2.2 kg/m 2 ) participated as controls. Plasma irisin, body weight, body composition, and hormones controlling energy homeostasis were measured.Results: Irisin levels were higher in obese subjects (353.1 6 18.6 ng/mL) than in those of normal-weight (198.4 6 7.8 ng/mL; P 0.001) and were also higher in men (340.9 6 20 ng/mL) than in women (267.6 6 12 ng/mL; P < 0.05). Moreover, irisin plasma levels were significantly correlated with high levels of direct and indirect adiposity markers, such as weight, BMI, waist circumference, and fat mass, as measured by bioimpedance, but not with height or leptin levels. Interestingly, irisin levels paralleled body weight reduction after the dietary treatment (week 8) and again returned to the baseline levels at 24 weeks in those patients regaining the lost weight.Conclusions: Irisin strongly reflects body fat mass, suggesting that the irisin circulating levels are conditioned by adiposity level. Am. J. Hum. Biol. 26:198-207, 2014.

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Secretome analysis of rat adipose tissues shows location-specific roles for each depot type

Cited by 68 publications

References 43 publications

Molecular Heterogeneities of Adipose Depots - Potential Effects on Adipose-Muscle Cross-Talk in Humans, Mice and Farm Animals

Molecular Heterogeneities of Adipose Depots - Potential Effects on Adipose-Muscle Cross-Talk in Humans, Mice and Farm Animals

Obesity-Induced Changes in Adipose Tissue Microenvironment and Their Impact on Cardiovascular Disease

Longitudinal variation of circulating irisin after an energy restriction‐induced weight loss and following weight regain in obese men and women

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