Secrets of Plasma-Deposited Polyoxazoline Functionality Lie in the Plasma Phase

MacGregor, Melanie; Michelmore, Andrew; Shirazi, H R Ghafarian; Whittle, Jason D.; Vasilev, Krasimir

doi:10.1021/acs.chemmater.7b03023

Cited by 28 publications

(29 citation statements)

References 23 publications

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“…All oxygen/nitrogen‐containing fragments (corresponding to amide functional groups and also oxazoline rings) have negative loadings on PC1, meaning that these fragments have higher intensity in the mass spectra of OXpp deposited at 50°C. It is worth to mention that the positive ion fragment with a nominal mass 72 amu (C 3 H 6 NO) was identified in a previous study by Macgregor et al to be characteristic of oxazoline ring. This fragment has a negative loading on PC1, therefore we may arguably say that the oxazoline rings content is higher within the OXpp coatings deposited at 50°C.…”

Section: Resultsmentioning

confidence: 93%

“…This makes the process cost‐effective, commercially attractive and environmentally friendly. Recently, our team pioneered low‐pressure RF plasma for the deposition of oxazoline‐based coatings for biomedical applications utilising 2‐methyl‐2‐oxazoline (OX) and 2‐ethyl‐2‐oxazoline as precursors . By tuning extrinsic plasma parameters such as applied RF power, plasma mode, duty cycle, and oxazoline monomer flow rate it was possible to achieve plasma coatings with excellent stability, biocompatibility and low biofouling properties.…”

Section: Introductionmentioning

confidence: 99%

“…Recently, our team pioneered low-pressure RF plasma for the deposition of oxazoline-based coatings for biomedical applications utilising 2-methyl-2-oxazoline (OX) and 2-ethyl-2-oxazoline as precursors. [29][30][31][32][33][34] By tuning extrinsic plasma parameters such as applied RF power, plasma mode, duty cycle, and oxazoline monomer flow rate it was possible to achieve plasma coatings with excellent stability, biocompatibility and low biofouling properties. In addition, it was found that those coatings are capable of reacting with carboxylic acid functionalised biomolecules.…”

Section: Introductionmentioning

confidence: 99%

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Deposition of 2‐oxazoline‐based plasma polymer coatings using atmospheric pressure helium plasma jet

Al‐Bataineh

Cavallaro

Michelmore

et al. 2019

Plasma Processes & Polymers

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We report on the use of helium plasma jet for plasma polymerisation of 2‐methyl‐2‐oxazoline (OX) on heated silicon substrates. The X‐ray photo electron spectroscopy (XPS) characterisation shows a substantial improvement in film stability in buffer solution when depositing at temperatures above 50°C. Principal component analysis of the time‐of‐flight–secondary ion mass spectrometry data shows excellent correlation with the XPS results, providing insights into the degree of crosslinking in the plasma coatings as a function of substrate temperature. Atomic force microscopy images showed the topography of OX plasma polymer coatings deposited at 80°C and 120°C to be smoother with lower surface roughness values compared to those produced at 50°C. Finally, an 80% reduction in the adhesion of Staphylococcus epidermidis is achieved at the centre of the plasma coatings deposited at 120°C.

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Section: Resultsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Deposition of 2‐oxazoline‐based plasma polymer coatings using atmospheric pressure helium plasma jet

Al‐Bataineh

Cavallaro

Michelmore

et al. 2019

Plasma Processes & Polymers

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“…Plasma coatings are deposited from the gaseous form of a selected precursor in which molecules are electrically excited to a plasma state. The nature of the technique offers unique versatility to deposit coatings of a wide range of functional groups, such as amine [32], carboxyl [33], hydroxyl [34], epoxy [35], oxazoline [36], chlorine [17], fluorine [37], siloxane [38], including from precursors that are not polymerizable by conventional means, such as ethanol [39]. The method is fast (seconds to minutes), can be completed in a single step and does not require the use of solvents as in the case of wet methods for surface modification [40,41].…”

Section: Plasma Depositionmentioning

confidence: 99%

“…A recently developed class of plasma polymers are those deposited from oxazoline precursors, such as 2-methyl-2-oxazoline and 2-ethyl-2-oxazoline [15,36,[51][52][53][54]. Regardless of the precursor used, when appropriate conditions for deposition are used, the process results in coatings with properties that are very useful for biomedical applications.…”

Section: Oxazoline Based Coatings That Inhibit Biofilm Growthmentioning

confidence: 99%

Nanoengineered Antibacterial Coatings and Materials: A Perspective

Vasilev

2019

Coatings

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This feature article begins by outlining the problem of infection and its implication on healthcare. The initial introductory section is followed by a description of the four distinct classes of antibacterial coatings and materials, i.e., bacteria repealing, contact killing, releasing and responsive, that were developed over the years by our team and others. Specific examples of each individual class of antibacterial materials and a discussion on the pros and cons of each strategy are provided. The article contains a dedicated section focused on silver nanoparticle based coatings and materials, which have attracted tremendous interest from the scientific and medical communities. The article concludes with the author’s view regarding the future of the field.

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Plasma Deposited Polyoxazoline Thin Films for the Biofunctionalization of Electrochemical Sensors

Eulate

Gheorghiu

Amoura

et al. 2021

Adv Materials Technologies

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Electrochemical immunosensors are an emerging technology for the fast, sensitive, and reliable diagnosis of diseases from bodily fluids. These sensors work by detecting a change in current upon analyte binding to an immuno‐functionalized electrode. Current methods of electrode functionalization are lengthy processes involving self‐assembled monolayer formation and wet chemistry biofunctionalization. Herein, thin films deposited from the plasma phase of oxazoline precursors are investigated and optimized as an alternative approach for electrode functionalization. The plasma‐enabled method has the advantage of being substrate independent and allows the spontaneous binding of biomolecules in physiological buffer. Surface sensitive analysis techniques are employed to characterize the thickness, reactivity, and stability of the thin films before investigating their electrochemical properties on indium tin oxide and gold electrodes including the feasibility to reduce charge transfer resistance with gold nanoparticles. Last, these films are employed to develop an immunosensor for the detection of free epithelial cell adhesion molecule with a limit of detection of 8.7 ng mL−1.

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Secrets of Plasma-Deposited Polyoxazoline Functionality Lie in the Plasma Phase

Cited by 28 publications

References 23 publications

Deposition of 2‐oxazoline‐based plasma polymer coatings using atmospheric pressure helium plasma jet

Deposition of 2‐oxazoline‐based plasma polymer coatings using atmospheric pressure helium plasma jet

Nanoengineered Antibacterial Coatings and Materials: A Perspective

Plasma Deposited Polyoxazoline Thin Films for the Biofunctionalization of Electrochemical Sensors

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