Winter wheat protection technology is aimed at preventing the mass spread of harmful biota and the possibility of its rapid restriction. Therewith, the main choice of pesticides and their timely use is precisely at the period when harmful organisms are in a sensitive stage to protective products, and plants are in the phase of forming and laying productivity elements. The purpose of the study is to examine the effectiveness of the proposed compositions of chemical preparations against harmful biota in improving the technology of winter wheat protection. When monitoring harmful organisms, generally accepted methods in phytopathology (Strakhov and Geschele scales), entomology (butterfly net, accounting site methods), and herbology (quantitative-weight) were used. The results of the study obtained during a production experiment to examine the effectiveness of product mixtures for a comprehensive system of protection of winter wheat crops are presented. Changes in the species and quantitative composition of winter wheat weed Synusia depending on the protection technology are established. The total number of weeds in the areas where the protection system was used decreased by 61.2 pcs./m2 compared to the control option. Changes in the number of pests are presented (a decrease in the Hessian fly by 26 specimens/100 w.s. (wheat stem), Swedish fly – 31 specimens/100 w.s., grass aphids – 20 specimens per stem, Haplothrips tritici – 34 specimens/100 w.s., bread carabus – 6 beetles/m2 ) when spraying winter wheat in the phases of exit into the tube and milk ripeness with insecticides Aktara 25 WG, 0.10 kg/ha + Karate seon 050 CS, 0.2 L/ha. The technical effectiveness of insecticides against pests was 73.8-89.5%, depending on the insect. It is proved that reliable protection against dominant diseases in the farm is achieved by using a combination of fungicides Alto Super 330 EC, 0.5 L/ha and Topsin M, WP, 1.0 kg/ha in the phase of entering the tube and Amistar extra 280 SC, 0.5 L/ha + Rex Duo, SC, 0.4 L/ha in the earing phase–beginning of flowering. The technical effectiveness of double spraying with recommended anti-disease products ranged from 77.1% to 86.8%. The proposed technology for protecting winter wheat from harmful organisms is effective, has passed production testing, and can be implemented in farms of all forms of ownership
