The family unit carries with it a responsibility of possibly being the most important predictor of positive child development. The aim of this systematic review is to identify and describe best practice models or processes in family-based intervention development. The following databases were included in the review: PsychArticles, Academic Search Complete, ERIC, SocIndex, Sage, Sabinet, and Pubmed. Peer-reviewed, English language, qualitative, quantitative, and mixed methods in nature conducted within the last 10 years. Interventions were required to include families as part of the programme as well as describe the model or process used in intervention development. Two self-developed data extraction tables were developed for this review. The articles included for review were heterogeneous in terms of the outcomes, and so a narrative synthesis was used. After yielding an initial search of 400 studies, 28 articles were finally included for extraction and analysis with varying levels of intervention strength. Interventions are further described in terms of reach, effectiveness, adoption, implementation, and maintenance dimensions. A feasible intervention appears to be one that is flexible, engages processes to recruit those who are most at-risk and is facilitated by someone known to or from the same community as the participants, can retain its participants, and can be evaluated with the same participants at a minimum of 6 months later.