Segundos tumores primarios en el cáncer escamoso de cabeza y cuello

Marcos, César; Espina, H. Fernández; Llorente, José Luís; Gutiérrez, Virginia Franco; Hermsen, Mario; Albalad, M.P. Cuesta; Nieto, Carlos Suárez

doi:10.1016/s0001-6519(06)78749-0

Cited by 14 publications

(8 citation statements)

References 24 publications

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“…In India, oral cancer is one of the major causes of cancer-related deaths 1 . Oral cancer includes all malignancies originating in the region of head and neck and has a high incidence, with a poor prognosis 3 4 . This may be due to the absence of effective diagnostic and prognostic methods which can guide suitable management at early stages.…”

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confidence: 99%

Association of −330 interleukin-2 gene polymorphism with oral cancer

Singh

Kumar

Ahmad

et al. 2017

Indian Journal of Medical Research

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Background & objectives:Cytokines play an important role in the development of cancer. Several single-nucleotide polymorphisms (SNPs) of cytokine genes have been reported to be associated with the development and severity of inflammatory diseases and cancer predisposition. This study was undertaken to evaluate a possible association of interleukin 2 (IL-2) (− 330A>C) gene polymorphisms with the susceptibility to oral cancer.Methods:The SNP in IL-2 (−330A>C) gene was genotyped in 300 oral cancer patients and in similar number of healthy volunteers by polymerase chain reaction (PCR)-restriction fragment length polymorphism and the association of the gene with the disease was evaluated.Results:IL-2 (−330A>C) gene polymorphism was significantly associated with oral cancer whereas it was neither associated with clinicopathological status nor with cancer pain. The AC heterozygous genotype was significantly associated with oral cancer patients as compared to controls [odds ratio (OR): 3.0; confidence interval (CI): 2.14-4.20; P<0.001]. The C allele frequency was also significantly associated with oral cancer (OR: 1.80; CI: 1.39-2.33; P<0.001). IL-2 (−330A>C) gene polymorphism was also associated with oral cancer in tobacco smokers and chewers.Interpretation & conclusions:Our results showed that oral cancer patients had significantly higher frequency of AA genotype but significantly lower frequency of AC genotype and C allele compared to controls. The IL-2 AC genotype and C allele of IL-2 (−330A>C) gene polymorphisms could be potential protective factors and might reduce the risk of oral cancer in Indian population.

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confidence: 99%

Association of −330 interleukin-2 gene polymorphism with oral cancer

Singh

Kumar

Ahmad

et al. 2017

Indian Journal of Medical Research

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“…El análisis crudo de la supervivencia mediante el Modelo de Riesgo Proporcional de Cox no está exento de limitaciones, pero parece igual de preciso que algunos análisis relativos si se tiene en cuenta la causa de la muerte 30 . En nuestro estudio, el análisis multivariante realizado para clarificar factores asociados a la supervivencia tras el CM muestra que tienen significativamente reducida la probabilidad de morir, por tanto, incrementada la supervivencia, los pacientes más jóvenes, más si son mujeres, diagnosticados en estadios locales y que recibieron cirugía o radioterapia radical como parte del tratamiento de alguno de sus cánceres (sobre todo radioterapia radical, ya que parece tener un efecto beneficioso al eliminar neoplasias simultáneas precoces 31 ). De ahí que deba extremarse la prevención en estas personas, sobre todo si cualquiera de los cánceres asienta en localizaciones que ofrecen buen pronóstico en la actualidad, como próstata, mama o piel no melanoma.…”

Section: Discussionunclassified

Análisis de la supervivencia en pacientes con cáncer múltiple, Asturias, 1975-2004

Pérez

Sánchez

Rodríguez

et al. 2008

Rev. Esp. Salud Publica

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“…Oral squamous cell carcinoma (OSCC) is a common malignant tumor of the oral cavity and has a high incidence with poor prognosis ( Alvarez Marcos et al, 2006 , Argiris et al, 2008 ). In India, OSCC is one of the major causes of cancer-related deaths.…”

Section: Introductionmentioning

confidence: 99%

Association of interleukin-6 genetic polymorphisms with risk of OSCC in Indian population

et al. 2015

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PurposeInterleukin-6 (IL-6) encodes a cytokine protein, which causes inflammation, maintains immune homeostasis and plays an essential role in oral pathogenesis. The aim of this study was to evaluate the association between IL-6 (− 174 and − 572) G/C promoter gene polymorphisms and risk of OSCC among Indians.MethodsSingle nucleotide polymorphism in IL-6 genes was genotyped in OSCC patients and healthy controls by PCR-RFLP method. Genotype and allele frequencies were analyzed by chi-square test and strength of associations by odds ratio with 95% confidence intervals.ResultsFrequency distribution of IL-6 (− 174) G/C gene polymorphism was significantly associated with OSCC patients in comparison to healthy controls (OR: 0.541, CI: 0.356–0.822; p: 0.004. However, frequency of IL-6 (− 572) G/C gene polymorphism was not significantly associated with OSCC patients (p > 0.05).ConclusionThe genotype GC and allele C of IL-6 (− 174) G/C gene polymorphism play a significant role in OSCC susceptibility.

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Segundos tumores primarios en el cáncer escamoso de cabeza y cuello

Cited by 14 publications

References 24 publications

Association of −330 interleukin-2 gene polymorphism with oral cancer

Association of −330 interleukin-2 gene polymorphism with oral cancer

Análisis de la supervivencia en pacientes con cáncer múltiple, Asturias, 1975-2004

Association of interleukin-6 genetic polymorphisms with risk of OSCC in Indian population

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