This study aims to analyse the role and contribution of small farms and small food businesses on the food system and food security. Drawing on a conceptual framework, methodology, and data from the EU H2020 ‘SALSA-Small farms, small food businesses and sustainable food and nutrition security’ project hereafter referred as SALSA project, this issue has been analysed in relation to four staple products (tomato, chicken, maize, and banana) in Santiago Island (Cabo Verde). The study follows a regional approach based on a detailed analysis of the territorial food systems and of the production/consumption balance of those staple products. The results show that the subsystems of production, processing, distribution, and consumption are different in the different food systems map for the four staple products, with complex and diversified interrelationships between small farms and related small businesses linking with various markets and all kinds of actors. Moreover, the evidence shows that small farms, in conjunction with small food businesses, are crucial to national food security in Santiago Island. The small farm is fundamental for greater food availability produced in the region, and the small food business is a key component playing a very important role by ensuring the stability of supply, being primarily responsible for establishing relationships to population centres.